Mapping the viral battlefield: SARS-CoV-2 infection dynamics among healthcare workers in Brazil
Abstract Background Understanding the dynamics of SARS-CoV-2 viral infection and factors associated with in-hospital transmission rates among healthcare workers (HCW) is crucial for their protection. Brazil experienced high mortality rates due to COVID-19, and limited data are available on transmiss...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | Human Resources for Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12960-024-00968-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850197839382052864 |
|---|---|
| author | Antonio Luiz Dal Bello Gasparoto Samara Vilas-Bôas Graeff Wellyngton Matheus de Souza Santiago Danielle Gomes da Silva Thaynara Azevedo dos Santos Leandro Martin Paulino Wellington Santos Fava Fernanda Paes Reis Claudia Stutz Adriana de Oliveira França Ana Tereza Gomes Guerrero Moureau Camila Amato Montalbano Everton Ferreira Lemos Crhistinne Cavalheiro Maymone Gonçalves Carlos Alberto Bento Júnior Rodrigo Pires Dallacqua Julio Croda Aline Pedroso Lorenz Cristina Souza Taynara Nogueira Martins Kassia Roberta Nogueira da Silva Alda Maria Teixeira Ferreira Adriana Carla Garcia Negri Anamaria Mello Miranda Paniago Ana Rita Coimbra Motta-Castro James Venturini Ana Paula da Costa Marques Sandra Maria do Valle Leone de Oliveira |
| author_facet | Antonio Luiz Dal Bello Gasparoto Samara Vilas-Bôas Graeff Wellyngton Matheus de Souza Santiago Danielle Gomes da Silva Thaynara Azevedo dos Santos Leandro Martin Paulino Wellington Santos Fava Fernanda Paes Reis Claudia Stutz Adriana de Oliveira França Ana Tereza Gomes Guerrero Moureau Camila Amato Montalbano Everton Ferreira Lemos Crhistinne Cavalheiro Maymone Gonçalves Carlos Alberto Bento Júnior Rodrigo Pires Dallacqua Julio Croda Aline Pedroso Lorenz Cristina Souza Taynara Nogueira Martins Kassia Roberta Nogueira da Silva Alda Maria Teixeira Ferreira Adriana Carla Garcia Negri Anamaria Mello Miranda Paniago Ana Rita Coimbra Motta-Castro James Venturini Ana Paula da Costa Marques Sandra Maria do Valle Leone de Oliveira |
| author_sort | Antonio Luiz Dal Bello Gasparoto |
| collection | DOAJ |
| description | Abstract Background Understanding the dynamics of SARS-CoV-2 viral infection and factors associated with in-hospital transmission rates among healthcare workers (HCW) is crucial for their protection. Brazil experienced high mortality rates due to COVID-19, and limited data are available on transmission of SARS-CoV-2 infection among HCW. This cohort study aimed to assess the dynamic of SARS-CoV-2 infections in HCW from two tertiary hospitals in central Brazil, one of them a Reference Hospital for COVID-19. Methods From May 2020 to January 2021, 554 HCW directly involved with COVID-19 care were followed through 12 biweekly visits. During these visits, blood, nasal, and oropharyngeal samples were collected, and participants underwent interviews. SARS-CoV-2 detection was carried out using RT-qPCR, while the assessment of seroprevalence was based on IgG detection. Additionally, 35 positive samples underwent viral whole-genome sequencing. Results The infection prevalence, as per RT-qPCR, was 28.5% (24.9–32.4), reflecting an overall attack rate ranging from 0.5% to 9.5%, marked by two peaks in August and December 2020. Oligosymptomatic and asymptomatic infections accounted for 14% of prevalent infections. The seroprevalence rate stood at 25.8%. The hospitalization rate was 8.2%, with a fatality rate of 1.3%. Risk factors associated with a positive diagnosis of COVID-19 included being male, working at the referral hospital, having a graduate-education level, and using hydroxychloroquine and zinc for prevention or treatment. One reinfection was identified. Absenteeism was 56.6%. The infection dynamics mirrored the pattern observed in the general population. Conclusion One-third of the professionals in the followed cohort were infected. Being male, working in a COVID-19 referral center, having a low level of education, and using medications for preventive treatment represented risk factors. Healthcare workers at the COVID-19 referral hospital exhibited a higher incidence rate compared to those at the non-referral hospital, increasing the plausibility that some of the infections occur in the hospital environment. |
| format | Article |
| id | doaj-art-a0edf68622764605a0b02cf38db3543a |
| institution | OA Journals |
| issn | 1478-4491 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Human Resources for Health |
| spelling | doaj-art-a0edf68622764605a0b02cf38db3543a2025-08-20T02:13:02ZengBMCHuman Resources for Health1478-44912025-02-0123111310.1186/s12960-024-00968-zMapping the viral battlefield: SARS-CoV-2 infection dynamics among healthcare workers in BrazilAntonio Luiz Dal Bello Gasparoto0Samara Vilas-Bôas Graeff1Wellyngton Matheus de Souza Santiago2Danielle Gomes da Silva3Thaynara Azevedo dos Santos4Leandro Martin Paulino5Wellington Santos Fava6Fernanda Paes Reis7Claudia Stutz8Adriana de Oliveira França9Ana Tereza Gomes Guerrero Moureau10Camila Amato Montalbano11Everton Ferreira Lemos12Crhistinne Cavalheiro Maymone Gonçalves13Carlos Alberto Bento Júnior14Rodrigo Pires Dallacqua15Julio Croda16Aline Pedroso Lorenz17Cristina Souza18Taynara Nogueira Martins19Kassia Roberta Nogueira da Silva20Alda Maria Teixeira Ferreira21Adriana Carla Garcia Negri22Anamaria Mello Miranda Paniago23Ana Rita Coimbra Motta-Castro24James Venturini25Ana Paula da Costa Marques26Sandra Maria do Valle Leone de Oliveira27Universidade Federal de Mato Grosso do sulUniversidade Federal de Mato Grosso do sulUniversidade Federal de Mato Grosso do sulUniversidade Federal de Mato Grosso do sulUniversidade Federal de Mato Grosso do sulUniversidade Federal de Mato Grosso do sulUniversidade Federal de Mato Grosso do sulUniversidade Federal de Mato Grosso do sulFundação Oswaldo Cruz (Fiocruz) - Ceará and Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição (FACFAN), Fundação Universidade Federal de Mato Grosso do Sul (UFMS)Universidade Federal de Mato Grosso do sulFundação Oswaldo Cruz - Vice-Presidência de Ambiente, Atenção e Promoção da Saúde (VPAAPS/FIOCRUZ-RJ)Universidade Estadual de Mato Grosso do sulUniversidade Estadual de Mato Grosso do sulUniversidade Federal de Mato Grosso do sulUniversidade Federal de Mato Grosso do sulUniversidade Federal de Mato Grosso do sulUniversidade Federal de Mato Grosso do sulUniversidade Federal de Mato Grosso do sulUniversidade Federal de Mato Grosso do sulUniversidade Federal de Mato Grosso do sulUniversidade Federal de Mato Grosso do sulUniversidade Federal de Mato Grosso do sulUniversidade Federal de Mato Grosso do sulUniversidade Federal de Mato Grosso do sulUniversidade Federal de Mato Grosso do sulUniversidade Federal de Mato Grosso do sulUniversidade Federal de Mato Grosso do sulUniversidade Federal de Mato Grosso do sulAbstract Background Understanding the dynamics of SARS-CoV-2 viral infection and factors associated with in-hospital transmission rates among healthcare workers (HCW) is crucial for their protection. Brazil experienced high mortality rates due to COVID-19, and limited data are available on transmission of SARS-CoV-2 infection among HCW. This cohort study aimed to assess the dynamic of SARS-CoV-2 infections in HCW from two tertiary hospitals in central Brazil, one of them a Reference Hospital for COVID-19. Methods From May 2020 to January 2021, 554 HCW directly involved with COVID-19 care were followed through 12 biweekly visits. During these visits, blood, nasal, and oropharyngeal samples were collected, and participants underwent interviews. SARS-CoV-2 detection was carried out using RT-qPCR, while the assessment of seroprevalence was based on IgG detection. Additionally, 35 positive samples underwent viral whole-genome sequencing. Results The infection prevalence, as per RT-qPCR, was 28.5% (24.9–32.4), reflecting an overall attack rate ranging from 0.5% to 9.5%, marked by two peaks in August and December 2020. Oligosymptomatic and asymptomatic infections accounted for 14% of prevalent infections. The seroprevalence rate stood at 25.8%. The hospitalization rate was 8.2%, with a fatality rate of 1.3%. Risk factors associated with a positive diagnosis of COVID-19 included being male, working at the referral hospital, having a graduate-education level, and using hydroxychloroquine and zinc for prevention or treatment. One reinfection was identified. Absenteeism was 56.6%. The infection dynamics mirrored the pattern observed in the general population. Conclusion One-third of the professionals in the followed cohort were infected. Being male, working in a COVID-19 referral center, having a low level of education, and using medications for preventive treatment represented risk factors. Healthcare workers at the COVID-19 referral hospital exhibited a higher incidence rate compared to those at the non-referral hospital, increasing the plausibility that some of the infections occur in the hospital environment.https://doi.org/10.1186/s12960-024-00968-zCOVID-19SARS-CoV-2Healthcare workerAsymptomatic infectionEpidemiology |
| spellingShingle | Antonio Luiz Dal Bello Gasparoto Samara Vilas-Bôas Graeff Wellyngton Matheus de Souza Santiago Danielle Gomes da Silva Thaynara Azevedo dos Santos Leandro Martin Paulino Wellington Santos Fava Fernanda Paes Reis Claudia Stutz Adriana de Oliveira França Ana Tereza Gomes Guerrero Moureau Camila Amato Montalbano Everton Ferreira Lemos Crhistinne Cavalheiro Maymone Gonçalves Carlos Alberto Bento Júnior Rodrigo Pires Dallacqua Julio Croda Aline Pedroso Lorenz Cristina Souza Taynara Nogueira Martins Kassia Roberta Nogueira da Silva Alda Maria Teixeira Ferreira Adriana Carla Garcia Negri Anamaria Mello Miranda Paniago Ana Rita Coimbra Motta-Castro James Venturini Ana Paula da Costa Marques Sandra Maria do Valle Leone de Oliveira Mapping the viral battlefield: SARS-CoV-2 infection dynamics among healthcare workers in Brazil Human Resources for Health COVID-19 SARS-CoV-2 Healthcare worker Asymptomatic infection Epidemiology |
| title | Mapping the viral battlefield: SARS-CoV-2 infection dynamics among healthcare workers in Brazil |
| title_full | Mapping the viral battlefield: SARS-CoV-2 infection dynamics among healthcare workers in Brazil |
| title_fullStr | Mapping the viral battlefield: SARS-CoV-2 infection dynamics among healthcare workers in Brazil |
| title_full_unstemmed | Mapping the viral battlefield: SARS-CoV-2 infection dynamics among healthcare workers in Brazil |
| title_short | Mapping the viral battlefield: SARS-CoV-2 infection dynamics among healthcare workers in Brazil |
| title_sort | mapping the viral battlefield sars cov 2 infection dynamics among healthcare workers in brazil |
| topic | COVID-19 SARS-CoV-2 Healthcare worker Asymptomatic infection Epidemiology |
| url | https://doi.org/10.1186/s12960-024-00968-z |
| work_keys_str_mv | AT antonioluizdalbellogasparoto mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil AT samaravilasboasgraeff mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil AT wellyngtonmatheusdesouzasantiago mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil AT daniellegomesdasilva mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil AT thaynaraazevedodossantos mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil AT leandromartinpaulino mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil AT wellingtonsantosfava mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil AT fernandapaesreis mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil AT claudiastutz mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil AT adrianadeoliveirafranca mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil AT anaterezagomesguerreromoureau mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil AT camilaamatomontalbano mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil AT evertonferreiralemos mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil AT crhistinnecavalheiromaymonegoncalves mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil AT carlosalbertobentojunior mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil AT rodrigopiresdallacqua mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil AT juliocroda mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil AT alinepedrosolorenz mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil AT cristinasouza mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil AT taynaranogueiramartins mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil AT kassiarobertanogueiradasilva mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil AT aldamariateixeiraferreira mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil AT adrianacarlagarcianegri mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil AT anamariamellomirandapaniago mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil AT anaritacoimbramottacastro mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil AT jamesventurini mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil AT anapauladacostamarques mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil AT sandramariadovalleleonedeoliveira mappingtheviralbattlefieldsarscov2infectiondynamicsamonghealthcareworkersinbrazil |