Screen of propionate-producing probiotic strains in attenuating murine colitis by modulating immune response and restoring the intestinal barrier

Screen of propionate-producing probiotic strains in attenuating murine colitis by modulating immune response and restoring the intestinal barrier

Intestinal dysbiosis is central to inflammatory bowel disease (IBD) development. Probiotics produce propionate, a short-chain fatty acid that restores intestinal balance and reduces inflammation.Comparative genomic analysis of propionate pathway integrity was performed to nominate 41 candidate strai...

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Main Authors: Ting Shu, Xizi Song, Silu Zhang, Xiaoli Zhou, Zhizhu Zhang, Pengfei Wang, Hu Canying, Jie Pan, Xiaoshuang Dai, Yan Tan, Wu Xiyang, Huicui Meng, Guoxun Xiao, Huaijie Hao
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Journal of Functional Foods
Subjects:
Inflammatory bowel disease
Propionate
Probiotics screening
Caco-2/HT29-MTX-E12 confluence epithelial model
Bifidobacterium breve
Pediococcus acidilactici
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464625000027
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