Cyclin-dependent kinases (CDKs) are key genes regulating early development of Neptunea arthritica cumingii: evidence from comparative transcriptome and proteome analyses
Abstract In this study, we applied comparative transcriptomics and proteomics techniques to systematically investigate the dynamic expression patterns of genes and proteins at various stages of early embryonic development of the gastropod Neptunea arthritica cumingii. Twelve cyclin-dependent kinase...
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BMC
2024-12-01
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| Series: | BMC Genomics |
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| Online Access: | https://doi.org/10.1186/s12864-024-10970-3 |
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| author | Fengxiao Lv Xinfan Ge Yaqing Chang Zhenlin Hao |
| author_facet | Fengxiao Lv Xinfan Ge Yaqing Chang Zhenlin Hao |
| author_sort | Fengxiao Lv |
| collection | DOAJ |
| description | Abstract In this study, we applied comparative transcriptomics and proteomics techniques to systematically investigate the dynamic expression patterns of genes and proteins at various stages of early embryonic development of the gastropod Neptunea arthritica cumingii. Twelve cyclin-dependent kinase (CDKs) genes and five downstream proteins associated with these CDKs were identified. Through techniques such as qRT-PCR, our data elucidate for the first time the regulatory functions of CDK family genes and establish CDKs as a pivotal gene cluster in the early embryonic development of N. cumingii. These findings not only enhance the understanding of molecular developmental biology in N. cumingii and marine gastropods in general but also provide significant insights into the mechanisms involved in early embryonic development in N. cumingii. Furthermore, our results provide theoretical guidance for advancing artificial breeding technology for N. cumingii. |
| format | Article |
| id | doaj-art-a0e9bc64f2cb4f9da10f8932be485490 |
| institution | OA Journals |
| issn | 1471-2164 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj-art-a0e9bc64f2cb4f9da10f8932be4854902025-08-20T01:57:15ZengBMCBMC Genomics1471-21642024-12-0125111710.1186/s12864-024-10970-3Cyclin-dependent kinases (CDKs) are key genes regulating early development of Neptunea arthritica cumingii: evidence from comparative transcriptome and proteome analysesFengxiao Lv0Xinfan Ge1Yaqing Chang2Zhenlin Hao3Key Laboratory of Mariculture and Stock Enhancement in North China’s Sea (Dalian Ocean University), Ministry of AgricultureKey Laboratory of Mariculture and Stock Enhancement in North China’s Sea (Dalian Ocean University), Ministry of AgricultureKey Laboratory of Mariculture and Stock Enhancement in North China’s Sea (Dalian Ocean University), Ministry of AgricultureKey Laboratory of Mariculture and Stock Enhancement in North China’s Sea (Dalian Ocean University), Ministry of AgricultureAbstract In this study, we applied comparative transcriptomics and proteomics techniques to systematically investigate the dynamic expression patterns of genes and proteins at various stages of early embryonic development of the gastropod Neptunea arthritica cumingii. Twelve cyclin-dependent kinase (CDKs) genes and five downstream proteins associated with these CDKs were identified. Through techniques such as qRT-PCR, our data elucidate for the first time the regulatory functions of CDK family genes and establish CDKs as a pivotal gene cluster in the early embryonic development of N. cumingii. These findings not only enhance the understanding of molecular developmental biology in N. cumingii and marine gastropods in general but also provide significant insights into the mechanisms involved in early embryonic development in N. cumingii. Furthermore, our results provide theoretical guidance for advancing artificial breeding technology for N. cumingii.https://doi.org/10.1186/s12864-024-10970-3N. cumingiiCDKsTranscriptomeProteomeEarly development |
| spellingShingle | Fengxiao Lv Xinfan Ge Yaqing Chang Zhenlin Hao Cyclin-dependent kinases (CDKs) are key genes regulating early development of Neptunea arthritica cumingii: evidence from comparative transcriptome and proteome analyses BMC Genomics N. cumingii CDKs Transcriptome Proteome Early development |
| title | Cyclin-dependent kinases (CDKs) are key genes regulating early development of Neptunea arthritica cumingii: evidence from comparative transcriptome and proteome analyses |
| title_full | Cyclin-dependent kinases (CDKs) are key genes regulating early development of Neptunea arthritica cumingii: evidence from comparative transcriptome and proteome analyses |
| title_fullStr | Cyclin-dependent kinases (CDKs) are key genes regulating early development of Neptunea arthritica cumingii: evidence from comparative transcriptome and proteome analyses |
| title_full_unstemmed | Cyclin-dependent kinases (CDKs) are key genes regulating early development of Neptunea arthritica cumingii: evidence from comparative transcriptome and proteome analyses |
| title_short | Cyclin-dependent kinases (CDKs) are key genes regulating early development of Neptunea arthritica cumingii: evidence from comparative transcriptome and proteome analyses |
| title_sort | cyclin dependent kinases cdks are key genes regulating early development of neptunea arthritica cumingii evidence from comparative transcriptome and proteome analyses |
| topic | N. cumingii CDKs Transcriptome Proteome Early development |
| url | https://doi.org/10.1186/s12864-024-10970-3 |
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