Indisulam synergizes with melphalan to inhibit Multiple Myeloma malignancy via targeting TOP2A.

Indisulam synergizes with melphalan to inhibit Multiple Myeloma malignancy via targeting TOP2A.

Multiple myeloma (MM) is the second most prevalent hematologic malignancy which remains uncurable. Numerous drugs have been discovered to inhibit MM cells. Indisulam, an aryl sulfonamide, has a potent anti-myeloma activity in vitro and in vivo. This study aims to explore the new mechanism of indisul...

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Main Authors: Chengyu Wu, Chao Wu, Jia Liu, Mingyuan Jia, Xinyi Zeng, Ze Fu, Ziqi He, Wenbin Xu, Hua Yan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0299019&type=printable
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