The role of TGF-β in the development of lung cancer in patients with chronic obstructive pulmonary disease
Background: Lung cancer and chronic obstructive pulmonary disease (COPD) have similar etiologic factors, but the relationship between these diseases has not been investigated. This study aimed to investigate whether TGF-β polymorphisms it is influential in the development of lung cancer in COPD pati...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co. Ltd.
2025-01-01
|
| Series: | Advances in Biomarker Sciences and Technology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2543106425000158 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849390676518633472 |
|---|---|
| author | Hatice Celik Tuglu Onder Ozturk Pınar Aslan Kosar |
| author_facet | Hatice Celik Tuglu Onder Ozturk Pınar Aslan Kosar |
| author_sort | Hatice Celik Tuglu |
| collection | DOAJ |
| description | Background: Lung cancer and chronic obstructive pulmonary disease (COPD) have similar etiologic factors, but the relationship between these diseases has not been investigated. This study aimed to investigate whether TGF-β polymorphisms it is influential in the development of lung cancer in COPD patients or not. Methods: Seventy-eight patients were divided into three groups; group Ⅰ: 28 patients with COPD and lung cancer, group Ⅱ: 30 patients with COPD, and group Ⅲ: 20 healthy people as a control group. We investigated 10 TGF-β polymorphisms in these patients over the age of 40 who were not relatives. Demographic data and polymorphism results were evaluated by an online access program provided by the Institute of Human Genetics using the Statistical Package for the Social Sciences v.22.0 program and the DeFinetti program provided by an online resource using the Armitage trend test. Results: Wild alleles were dominant in healthy individuals; rs11466345 T > C, rs1800470-2 G > C, rs1800471-1 C > G, rs1800471-2 C > T, and rs1877474-2 T > G polymorphisms. They were not associated with lung cancer and COPD development. However, rs1800470–1 G > A and rs1800469 A > G polymorphisms might have protective effects against lung cancer development, and rs1800470–1 G > A polymorphism could be more protective in former smokers than in smokers. If further studies confirm these findings, rs1800470–1 G > A and rs1800469 A > G may serve as protective factors against lung cancer development. Additionally, rs1800470-1 G > A polymorphism may provide greater protective effects against lung cancer in former smokers compared to current smokers. Conclusions: According to our study, although some TGF-β polymorphisms may be protective against lung cancer development in COPD patients, the limited sample size—especially in the control group—and inclusion of only male participants restrict the statistical power and generalizability of these findings. Nonetheless, we believe our results provide valuable preliminary insights that may guide future research. Larger, more diverse studies are needed to confirm and expand upon these findings. |
| format | Article |
| id | doaj-art-a0d0e9e252dc4044a228fb8ca1c84e9a |
| institution | Kabale University |
| issn | 2543-1064 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Advances in Biomarker Sciences and Technology |
| spelling | doaj-art-a0d0e9e252dc4044a228fb8ca1c84e9a2025-08-20T03:41:26ZengKeAi Communications Co. Ltd.Advances in Biomarker Sciences and Technology2543-10642025-01-01722223710.1016/j.abst.2025.08.001The role of TGF-β in the development of lung cancer in patients with chronic obstructive pulmonary diseaseHatice Celik Tuglu0Onder Ozturk1Pınar Aslan Kosar2Department of Allergy and Immunology Diseases Ankara Ataturk Sanatoryum Training and Research Hospital, Türkiye; Corresponding author. Department of Allergy and Immunology Diseases Ankara Ataturk Sanatoryum Training and Research Hospital, Türkiye.Department of Pulmonology, Medical School of Süleyman Demirel University, Isparta, TurkiyeDepartment of Medical Biology, Medical School of Süleyman Demirel University, Isparta, TurkiyeBackground: Lung cancer and chronic obstructive pulmonary disease (COPD) have similar etiologic factors, but the relationship between these diseases has not been investigated. This study aimed to investigate whether TGF-β polymorphisms it is influential in the development of lung cancer in COPD patients or not. Methods: Seventy-eight patients were divided into three groups; group Ⅰ: 28 patients with COPD and lung cancer, group Ⅱ: 30 patients with COPD, and group Ⅲ: 20 healthy people as a control group. We investigated 10 TGF-β polymorphisms in these patients over the age of 40 who were not relatives. Demographic data and polymorphism results were evaluated by an online access program provided by the Institute of Human Genetics using the Statistical Package for the Social Sciences v.22.0 program and the DeFinetti program provided by an online resource using the Armitage trend test. Results: Wild alleles were dominant in healthy individuals; rs11466345 T > C, rs1800470-2 G > C, rs1800471-1 C > G, rs1800471-2 C > T, and rs1877474-2 T > G polymorphisms. They were not associated with lung cancer and COPD development. However, rs1800470–1 G > A and rs1800469 A > G polymorphisms might have protective effects against lung cancer development, and rs1800470–1 G > A polymorphism could be more protective in former smokers than in smokers. If further studies confirm these findings, rs1800470–1 G > A and rs1800469 A > G may serve as protective factors against lung cancer development. Additionally, rs1800470-1 G > A polymorphism may provide greater protective effects against lung cancer in former smokers compared to current smokers. Conclusions: According to our study, although some TGF-β polymorphisms may be protective against lung cancer development in COPD patients, the limited sample size—especially in the control group—and inclusion of only male participants restrict the statistical power and generalizability of these findings. Nonetheless, we believe our results provide valuable preliminary insights that may guide future research. Larger, more diverse studies are needed to confirm and expand upon these findings.http://www.sciencedirect.com/science/article/pii/S2543106425000158Chronic obstructive pulmonary diseaseLung cancerSmokersTGF-β polymorphisms |
| spellingShingle | Hatice Celik Tuglu Onder Ozturk Pınar Aslan Kosar The role of TGF-β in the development of lung cancer in patients with chronic obstructive pulmonary disease Advances in Biomarker Sciences and Technology Chronic obstructive pulmonary disease Lung cancer Smokers TGF-β polymorphisms |
| title | The role of TGF-β in the development of lung cancer in patients with chronic obstructive pulmonary disease |
| title_full | The role of TGF-β in the development of lung cancer in patients with chronic obstructive pulmonary disease |
| title_fullStr | The role of TGF-β in the development of lung cancer in patients with chronic obstructive pulmonary disease |
| title_full_unstemmed | The role of TGF-β in the development of lung cancer in patients with chronic obstructive pulmonary disease |
| title_short | The role of TGF-β in the development of lung cancer in patients with chronic obstructive pulmonary disease |
| title_sort | role of tgf β in the development of lung cancer in patients with chronic obstructive pulmonary disease |
| topic | Chronic obstructive pulmonary disease Lung cancer Smokers TGF-β polymorphisms |
| url | http://www.sciencedirect.com/science/article/pii/S2543106425000158 |
| work_keys_str_mv | AT haticeceliktuglu theroleoftgfbinthedevelopmentoflungcancerinpatientswithchronicobstructivepulmonarydisease AT onderozturk theroleoftgfbinthedevelopmentoflungcancerinpatientswithchronicobstructivepulmonarydisease AT pınaraslankosar theroleoftgfbinthedevelopmentoflungcancerinpatientswithchronicobstructivepulmonarydisease AT haticeceliktuglu roleoftgfbinthedevelopmentoflungcancerinpatientswithchronicobstructivepulmonarydisease AT onderozturk roleoftgfbinthedevelopmentoflungcancerinpatientswithchronicobstructivepulmonarydisease AT pınaraslankosar roleoftgfbinthedevelopmentoflungcancerinpatientswithchronicobstructivepulmonarydisease |