A Rare Case of Severe Facial Disfiguration Due to Extranodal NK/T-Cell Lymphoma
Huiyi Deng,1,2 Qintai Yang,1,2 Zhaohui Shi1,2 1Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People’s Republic of China; 2Department of Allergy, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People’s Repu...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-01-01
|
| Series: | Journal of Asthma and Allergy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/a-rare-case-of-severe-facial-disfiguration-due-to-extranodal-nkt-cell--peer-reviewed-fulltext-article-JAA |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841555993632178176 |
|---|---|
| author | Deng H Yang Q Shi Z |
| author_facet | Deng H Yang Q Shi Z |
| author_sort | Deng H |
| collection | DOAJ |
| description | Huiyi Deng,1,2 Qintai Yang,1,2 Zhaohui Shi1,2 1Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People’s Republic of China; 2Department of Allergy, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People’s Republic of ChinaCorrespondence: Zhaohui Shi, Department of Otolaryngology-Head and Neck Surgery, Department of Allergy, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People’s Republic of China, Email shizhh35@mail.sysu.edu.cnBackground: Extranodal NK/T-cell lymphoma, nasal type (ENKTCL-NT) is a rare, highly invasive Epstein-Barr virus associated hematological malignant tumor with an unfavorable prognosis. Although ENKTCL-NT has been previously reported, no relevant article has provided an intuitive, progressive series of schematic illustrations of the rapid progression of facial ulcers.Objective: This article reports a serious case of ENKTCL-NT that involved the entire process from onset to death.Case Summary: A 67-year-old man suffered a facial lesion started at the right ala nasi. The wound continued to spread uncontrollably to the nasion and the nasolabial groove. Subsequently, he used an unauthorized external application of herbal medicine, which unfortunately resulted in further expansion of the wound, encompassing the area from the right eyelid to the left inner canthus, extending up to the eyebrow arch, down to the right ala nasi, and deep into the nasal bone over six months. Histopathological analysis of the two biopsies revealed inflammatory necrotic granulation tissue.Conclusion: Nasal extranodal NK/T-cell lymphoma presenting with non-specific symptoms could easily lead to misdiagnosis. It progresses quickly, while adequate, repeated, and multiple spot biopsies for histopathologic examination help confirm the diagnosis.Keywords: ENKTCL-NT, misdiagnose, biopsy, pathology |
| format | Article |
| id | doaj-art-a0cfe515572b417f959a2b6c026eb397 |
| institution | Kabale University |
| issn | 1178-6965 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Asthma and Allergy |
| spelling | doaj-art-a0cfe515572b417f959a2b6c026eb3972025-01-07T16:42:40ZengDove Medical PressJournal of Asthma and Allergy1178-69652025-01-01Volume 18273199061A Rare Case of Severe Facial Disfiguration Due to Extranodal NK/T-Cell LymphomaDeng HYang QShi ZHuiyi Deng,1,2 Qintai Yang,1,2 Zhaohui Shi1,2 1Department of Otolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People’s Republic of China; 2Department of Allergy, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People’s Republic of ChinaCorrespondence: Zhaohui Shi, Department of Otolaryngology-Head and Neck Surgery, Department of Allergy, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People’s Republic of China, Email shizhh35@mail.sysu.edu.cnBackground: Extranodal NK/T-cell lymphoma, nasal type (ENKTCL-NT) is a rare, highly invasive Epstein-Barr virus associated hematological malignant tumor with an unfavorable prognosis. Although ENKTCL-NT has been previously reported, no relevant article has provided an intuitive, progressive series of schematic illustrations of the rapid progression of facial ulcers.Objective: This article reports a serious case of ENKTCL-NT that involved the entire process from onset to death.Case Summary: A 67-year-old man suffered a facial lesion started at the right ala nasi. The wound continued to spread uncontrollably to the nasion and the nasolabial groove. Subsequently, he used an unauthorized external application of herbal medicine, which unfortunately resulted in further expansion of the wound, encompassing the area from the right eyelid to the left inner canthus, extending up to the eyebrow arch, down to the right ala nasi, and deep into the nasal bone over six months. Histopathological analysis of the two biopsies revealed inflammatory necrotic granulation tissue.Conclusion: Nasal extranodal NK/T-cell lymphoma presenting with non-specific symptoms could easily lead to misdiagnosis. It progresses quickly, while adequate, repeated, and multiple spot biopsies for histopathologic examination help confirm the diagnosis.Keywords: ENKTCL-NT, misdiagnose, biopsy, pathologyhttps://www.dovepress.com/a-rare-case-of-severe-facial-disfiguration-due-to-extranodal-nkt-cell--peer-reviewed-fulltext-article-JAAenktcl-ntmisdiagnosebiopsypathology |
| spellingShingle | Deng H Yang Q Shi Z A Rare Case of Severe Facial Disfiguration Due to Extranodal NK/T-Cell Lymphoma Journal of Asthma and Allergy enktcl-nt misdiagnose biopsy pathology |
| title | A Rare Case of Severe Facial Disfiguration Due to Extranodal NK/T-Cell Lymphoma |
| title_full | A Rare Case of Severe Facial Disfiguration Due to Extranodal NK/T-Cell Lymphoma |
| title_fullStr | A Rare Case of Severe Facial Disfiguration Due to Extranodal NK/T-Cell Lymphoma |
| title_full_unstemmed | A Rare Case of Severe Facial Disfiguration Due to Extranodal NK/T-Cell Lymphoma |
| title_short | A Rare Case of Severe Facial Disfiguration Due to Extranodal NK/T-Cell Lymphoma |
| title_sort | rare case of severe facial disfiguration due to extranodal nk t cell lymphoma |
| topic | enktcl-nt misdiagnose biopsy pathology |
| url | https://www.dovepress.com/a-rare-case-of-severe-facial-disfiguration-due-to-extranodal-nkt-cell--peer-reviewed-fulltext-article-JAA |
| work_keys_str_mv | AT dengh ararecaseofseverefacialdisfigurationduetoextranodalnktcelllymphoma AT yangq ararecaseofseverefacialdisfigurationduetoextranodalnktcelllymphoma AT shiz ararecaseofseverefacialdisfigurationduetoextranodalnktcelllymphoma AT dengh rarecaseofseverefacialdisfigurationduetoextranodalnktcelllymphoma AT yangq rarecaseofseverefacialdisfigurationduetoextranodalnktcelllymphoma AT shiz rarecaseofseverefacialdisfigurationduetoextranodalnktcelllymphoma |