CA3 bridges dietary restriction to glioblastoma suppression and tumor progression as a key downstream effector
Abstract Dietary restriction (DR) is recognized as a health-promoting, non-pharmacological intervention with demonstrated inhibitory effects on the initiation and progression of cancer. The molecular mechanisms underpinning DR’s anticancer activity are pivotal, with documented evidence of its suppre...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-05-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-01986-0 |
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| author | Junxiang Mao Zhibiao Cai Dong Xie Man Guo Yu Gao Guohui Zhao Jie Zhou |
| author_facet | Junxiang Mao Zhibiao Cai Dong Xie Man Guo Yu Gao Guohui Zhao Jie Zhou |
| author_sort | Junxiang Mao |
| collection | DOAJ |
| description | Abstract Dietary restriction (DR) is recognized as a health-promoting, non-pharmacological intervention with demonstrated inhibitory effects on the initiation and progression of cancer. The molecular mechanisms underpinning DR’s anticancer activity are pivotal, with documented evidence of its suppressive role across a spectrum of cancers. Glioblastoma multiforme (GBM) represents an aggressively malignant intracranial neoplasm, and despite incremental therapeutic and managerial advancements, the clinical outcomes remain suboptimal. Consequently, the discovery of novel molecular markers to augment diagnostic accuracy and therapeutic efficacy is imperative. Employing an array of bioinformatics strategies, we conducted an exhaustive analysis of molecules associated with DR, culminating in the identification of CA3 as a novel molecular marker for GBM. We evaluated its diagnostic and therapeutic potential within GBM. Our data indicate that the DR-associated molecule CA3 may exhibit correlations with multiple GBM phenotypes, including the immune contexture, with particular emphasis on the tumor’s invasive and migratory capacities. Subsequent inquiries confirmed that modulating CA3 expression can effectively curb the genesis and progression of GBM. Our research substantiates that DR can mitigate the onset and development of GBM via the gene CA3, thereby validating a novel GBM marker and proposing a non-pharmacological interventional approach for this life-threatening condition. |
| format | Article |
| id | doaj-art-a0cdbda437ee4927a7443c47c8a90284 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-a0cdbda437ee4927a7443c47c8a902842025-08-20T03:16:32ZengNature PortfolioScientific Reports2045-23222025-05-0115112610.1038/s41598-025-01986-0CA3 bridges dietary restriction to glioblastoma suppression and tumor progression as a key downstream effectorJunxiang Mao0Zhibiao Cai1Dong Xie2Man Guo3Yu Gao4Guohui Zhao5Jie Zhou6The Second Hospital & Clinical Medical School, Lanzhou UniversityDepartment of Neurosurgery, The 940 th Hospital of Joint Logistics Support force of Chinese People’s Liberation ArmyDepartment of First Clinical College of Medicine, Gansu University of Traditional Chinese MedicineDepartment of First Clinical College of Medicine, Gansu University of Traditional Chinese MedicineDepartment of First Clinical College of Medicine, Gansu University of Traditional Chinese MedicineDepartment of First Clinical College of Medicine, Gansu University of Traditional Chinese MedicineThe Second Hospital & Clinical Medical School, Lanzhou UniversityAbstract Dietary restriction (DR) is recognized as a health-promoting, non-pharmacological intervention with demonstrated inhibitory effects on the initiation and progression of cancer. The molecular mechanisms underpinning DR’s anticancer activity are pivotal, with documented evidence of its suppressive role across a spectrum of cancers. Glioblastoma multiforme (GBM) represents an aggressively malignant intracranial neoplasm, and despite incremental therapeutic and managerial advancements, the clinical outcomes remain suboptimal. Consequently, the discovery of novel molecular markers to augment diagnostic accuracy and therapeutic efficacy is imperative. Employing an array of bioinformatics strategies, we conducted an exhaustive analysis of molecules associated with DR, culminating in the identification of CA3 as a novel molecular marker for GBM. We evaluated its diagnostic and therapeutic potential within GBM. Our data indicate that the DR-associated molecule CA3 may exhibit correlations with multiple GBM phenotypes, including the immune contexture, with particular emphasis on the tumor’s invasive and migratory capacities. Subsequent inquiries confirmed that modulating CA3 expression can effectively curb the genesis and progression of GBM. Our research substantiates that DR can mitigate the onset and development of GBM via the gene CA3, thereby validating a novel GBM marker and proposing a non-pharmacological interventional approach for this life-threatening condition.https://doi.org/10.1038/s41598-025-01986-0Dietary restrictionGlioblastoma multiformeCA3Single-cell transcriptomeBiomarker |
| spellingShingle | Junxiang Mao Zhibiao Cai Dong Xie Man Guo Yu Gao Guohui Zhao Jie Zhou CA3 bridges dietary restriction to glioblastoma suppression and tumor progression as a key downstream effector Scientific Reports Dietary restriction Glioblastoma multiforme CA3 Single-cell transcriptome Biomarker |
| title | CA3 bridges dietary restriction to glioblastoma suppression and tumor progression as a key downstream effector |
| title_full | CA3 bridges dietary restriction to glioblastoma suppression and tumor progression as a key downstream effector |
| title_fullStr | CA3 bridges dietary restriction to glioblastoma suppression and tumor progression as a key downstream effector |
| title_full_unstemmed | CA3 bridges dietary restriction to glioblastoma suppression and tumor progression as a key downstream effector |
| title_short | CA3 bridges dietary restriction to glioblastoma suppression and tumor progression as a key downstream effector |
| title_sort | ca3 bridges dietary restriction to glioblastoma suppression and tumor progression as a key downstream effector |
| topic | Dietary restriction Glioblastoma multiforme CA3 Single-cell transcriptome Biomarker |
| url | https://doi.org/10.1038/s41598-025-01986-0 |
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