Vector coding and place coding in hippocampus share a common directional signal
Abstract Vector coding is a major mechanism by which neural systems represent an animal’s location in both global and local, item-based reference frames. Landmark vector cells (LVCs) in the hippocampus complement classic place cells by encoding vector relationships between the organism and specific...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-54935-2 |
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| author | Yue-Qing Zhou Vyash Puliyadi Xiaojing Chen Joonhee Leo Lee Lan-Yuan Zhang James J. Knierim |
| author_facet | Yue-Qing Zhou Vyash Puliyadi Xiaojing Chen Joonhee Leo Lee Lan-Yuan Zhang James J. Knierim |
| author_sort | Yue-Qing Zhou |
| collection | DOAJ |
| description | Abstract Vector coding is a major mechanism by which neural systems represent an animal’s location in both global and local, item-based reference frames. Landmark vector cells (LVCs) in the hippocampus complement classic place cells by encoding vector relationships between the organism and specific landmarks. How these place- and vector-coding properties interact is not known. We recorded place cells and LVCs using calcium imaging of the CA1 region of freely moving rats during cue-card rotation studies. Place fields rotated around the center of the platform to follow the cue rotation, whereas the fields of simultaneously recorded LVCs rotated by the same amount around the nearby landmarks. Some neurons demonstrated conjunctive coding of both classic place field properties and LVC properties. These results demonstrate that CA1 neurons employ a common directional input, presumably provided by the head direction cell system, to encode animals’ locations in both world-centered and landmark-centered reference frames. |
| format | Article |
| id | doaj-art-a0c2c5f94ec149e98b567956abe253cd |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-a0c2c5f94ec149e98b567956abe253cd2025-08-20T02:30:54ZengNature PortfolioNature Communications2041-17232024-12-0115111510.1038/s41467-024-54935-2Vector coding and place coding in hippocampus share a common directional signalYue-Qing Zhou0Vyash Puliyadi1Xiaojing Chen2Joonhee Leo Lee3Lan-Yuan Zhang4James J. Knierim5Zanvyl Krieger Mind/Brain Institute, Johns Hopkins UniversityZanvyl Krieger Mind/Brain Institute, Johns Hopkins UniversityZanvyl Krieger Mind/Brain Institute, Johns Hopkins UniversityZanvyl Krieger Mind/Brain Institute, Johns Hopkins UniversityDepartment of Anatomy and Neurobiology, University of Maryland School of MedicineZanvyl Krieger Mind/Brain Institute, Johns Hopkins UniversityAbstract Vector coding is a major mechanism by which neural systems represent an animal’s location in both global and local, item-based reference frames. Landmark vector cells (LVCs) in the hippocampus complement classic place cells by encoding vector relationships between the organism and specific landmarks. How these place- and vector-coding properties interact is not known. We recorded place cells and LVCs using calcium imaging of the CA1 region of freely moving rats during cue-card rotation studies. Place fields rotated around the center of the platform to follow the cue rotation, whereas the fields of simultaneously recorded LVCs rotated by the same amount around the nearby landmarks. Some neurons demonstrated conjunctive coding of both classic place field properties and LVC properties. These results demonstrate that CA1 neurons employ a common directional input, presumably provided by the head direction cell system, to encode animals’ locations in both world-centered and landmark-centered reference frames.https://doi.org/10.1038/s41467-024-54935-2 |
| spellingShingle | Yue-Qing Zhou Vyash Puliyadi Xiaojing Chen Joonhee Leo Lee Lan-Yuan Zhang James J. Knierim Vector coding and place coding in hippocampus share a common directional signal Nature Communications |
| title | Vector coding and place coding in hippocampus share a common directional signal |
| title_full | Vector coding and place coding in hippocampus share a common directional signal |
| title_fullStr | Vector coding and place coding in hippocampus share a common directional signal |
| title_full_unstemmed | Vector coding and place coding in hippocampus share a common directional signal |
| title_short | Vector coding and place coding in hippocampus share a common directional signal |
| title_sort | vector coding and place coding in hippocampus share a common directional signal |
| url | https://doi.org/10.1038/s41467-024-54935-2 |
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