Comparison of monophasic and biphasic hyaluronic acid fillers: a meta-analysis across facial regions in Asian populations
Hyaluronic acid (HA) fillers are widely used in nonsurgical facial rejuvenation to restore volume and enhance contour. Monophasic and biphasic fillers are commonly used; however, there is limited consensus regarding their optimal application in different facial regions, particularly in Asian populat...
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Korean Society of Korean Cosmetic Surgery and medicine
2024-12-01
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| Series: | Journal of Cosmetic Medicine |
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| Online Access: | http://www.jcosmetmed.org/journal/view.html?doi=10.25056/JCM.2024.8.2.73 |
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| author | Ingyu Lee JinHan Lee SeoWon Kang Hyungin Cho Ki Won Lee Dongkeun Lim |
| author_facet | Ingyu Lee JinHan Lee SeoWon Kang Hyungin Cho Ki Won Lee Dongkeun Lim |
| author_sort | Ingyu Lee |
| collection | DOAJ |
| description | Hyaluronic acid (HA) fillers are widely used in nonsurgical facial rejuvenation to restore volume and enhance contour. Monophasic and biphasic fillers are commonly used; however, there is limited consensus regarding their optimal application in different facial regions, particularly in Asian populations with unique anatomical and aesthetic preferences. This meta-analysis evaluated the efficacy and safety of monophasic and biphasic HA fillers, focusing on key facial areas, including the nasolabial folds, cheeks, and nose, in Asian populations. A systematic literature search of the PubMed, KoreaMed, DBpia, Google Scholar, Embase, and Cochrane Library databases was performed to identify relevant studies published between 2014 and 2023. After screening 416 records and assessing the full texts, 17 studies comprising 1,765 patients were included. Data regarding patient satisfaction, adverse effects, and HA-filler performance were extracted and analyzed using a random effects model. Standardized mean difference (SMD) with corresponding 95% confidence interval were calculated. Monophasic fillers demonstrated superior integration in dynamic areas, such as the nasolabial folds, with fewer side effects such as swelling and bruising. Biphasic fillers demonstrated greater volume retention and structural support for deeper applications, such as nose reshaping and cheek augmentation, but had higher rates of transient adverse effects. The SMD values ranged from 0.60 to 0.70, with minimal publication bias. Monophasic fillers excelled in the dynamic regions, whereas biphasic fillers were more optimal for deeper structural supports. Combining both filler types may optimize outcomes. Further research investigating long-term efficacy and safety is warranted. |
| format | Article |
| id | doaj-art-a0c23ed56ead4dcaa1ef9f82426e94c9 |
| institution | Kabale University |
| issn | 2586-0585 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Korean Society of Korean Cosmetic Surgery and medicine |
| record_format | Article |
| series | Journal of Cosmetic Medicine |
| spelling | doaj-art-a0c23ed56ead4dcaa1ef9f82426e94c92025-01-06T05:22:11ZengKorean Society of Korean Cosmetic Surgery and medicineJournal of Cosmetic Medicine2586-05852024-12-0182738010.25056/JCM.2024.8.2.73JCM.2024.8.2.73Comparison of monophasic and biphasic hyaluronic acid fillers: a meta-analysis across facial regions in Asian populationsIngyu Lee0JinHan Lee1SeoWon Kang2Hyungin Cho3Ki Won Lee4Dongkeun Lim5Department of Dermatology, Eco Samsung Orthopedic Clinic, Jeonju, Rep. of KoreaDepartment of Dermatology, Eco Samsung Orthopedic Clinic, Jeonju, Rep. of KoreaDepartment of Dermatology, Eco Samsung Orthopedic Clinic, Jeonju, Rep. of KoreaDepartment of Dermatology, Eco Samsung Orthopedic Clinic, Jeonju, Rep. of KoreaDepartment of Dermatology, Eco Samsung Orthopedic Clinic, Jeonju, Rep. of KoreaDepartment of Orthopedic Surgery, Eulji University Medical Center, Seoul, Rep. of KoreaHyaluronic acid (HA) fillers are widely used in nonsurgical facial rejuvenation to restore volume and enhance contour. Monophasic and biphasic fillers are commonly used; however, there is limited consensus regarding their optimal application in different facial regions, particularly in Asian populations with unique anatomical and aesthetic preferences. This meta-analysis evaluated the efficacy and safety of monophasic and biphasic HA fillers, focusing on key facial areas, including the nasolabial folds, cheeks, and nose, in Asian populations. A systematic literature search of the PubMed, KoreaMed, DBpia, Google Scholar, Embase, and Cochrane Library databases was performed to identify relevant studies published between 2014 and 2023. After screening 416 records and assessing the full texts, 17 studies comprising 1,765 patients were included. Data regarding patient satisfaction, adverse effects, and HA-filler performance were extracted and analyzed using a random effects model. Standardized mean difference (SMD) with corresponding 95% confidence interval were calculated. Monophasic fillers demonstrated superior integration in dynamic areas, such as the nasolabial folds, with fewer side effects such as swelling and bruising. Biphasic fillers demonstrated greater volume retention and structural support for deeper applications, such as nose reshaping and cheek augmentation, but had higher rates of transient adverse effects. The SMD values ranged from 0.60 to 0.70, with minimal publication bias. Monophasic fillers excelled in the dynamic regions, whereas biphasic fillers were more optimal for deeper structural supports. Combining both filler types may optimize outcomes. Further research investigating long-term efficacy and safety is warranted.http://www.jcosmetmed.org/journal/view.html?doi=10.25056/JCM.2024.8.2.73asian populations; biphasic fillers; facial rejuvenation; hyaluronic acid fillers; monophasic fillers; nasolabial folds |
| spellingShingle | Ingyu Lee JinHan Lee SeoWon Kang Hyungin Cho Ki Won Lee Dongkeun Lim Comparison of monophasic and biphasic hyaluronic acid fillers: a meta-analysis across facial regions in Asian populations Journal of Cosmetic Medicine asian populations; biphasic fillers; facial rejuvenation; hyaluronic acid fillers; monophasic fillers; nasolabial folds |
| title | Comparison of monophasic and biphasic hyaluronic acid fillers: a meta-analysis across facial regions in Asian populations |
| title_full | Comparison of monophasic and biphasic hyaluronic acid fillers: a meta-analysis across facial regions in Asian populations |
| title_fullStr | Comparison of monophasic and biphasic hyaluronic acid fillers: a meta-analysis across facial regions in Asian populations |
| title_full_unstemmed | Comparison of monophasic and biphasic hyaluronic acid fillers: a meta-analysis across facial regions in Asian populations |
| title_short | Comparison of monophasic and biphasic hyaluronic acid fillers: a meta-analysis across facial regions in Asian populations |
| title_sort | comparison of monophasic and biphasic hyaluronic acid fillers a meta analysis across facial regions in asian populations |
| topic | asian populations; biphasic fillers; facial rejuvenation; hyaluronic acid fillers; monophasic fillers; nasolabial folds |
| url | http://www.jcosmetmed.org/journal/view.html?doi=10.25056/JCM.2024.8.2.73 |
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