Endoplasmic reticulum stress disrupts signaling via altered processing of transmembrane receptors

Endoplasmic reticulum stress disrupts signaling via altered processing of transmembrane receptors

Abstract Cell communication systems based on polypeptide ligands use transmembrane receptors to transmit signals across the plasma membrane. In their biogenesis, receptors depend on the endoplasmic reticulum (ER)-Golgi system for folding, maturation, transport and localization to the cell surface. E...

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Main Authors: Michaela Bosakova, Sara P. Abraham, Davis Wachtell, Jennifer T. Zieba, Alexander Kot, Alexandru Nita, Aleksandra Anna Czyrek, Adolf Koudelka, Vlad-Constantin Ursachi, Zuzana Feketova, Gustavo Rico-Llanos, Katerina Svozilova, Petra Kocerova, Bohumil Fafilek, Tomas Gregor, Jana Kotaskova, Ivan Duran, Petr Vanhara, Michael Doubek, Jiri Mayer, Karel Soucek, Deborah Krakow, Pavel Krejci
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Cell Communication and Signaling
Subjects:
Endoplasmic reticulum
ER
Stress
Receptor
Transmembrane
Signaling
Online Access:https://doi.org/10.1186/s12964-025-02208-w
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