Neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; systemic immune-inflammatory Index: inflammatory indicators of cognitive impairment in schizophrenia patients
ObjectiveThe present study sought to evaluate the correlation between cognitive impairment (CI) and inflammatory indicators such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammatory index (SII) in schizophrenia patients.MethodsThis study inclu...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1552451/full |
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| author | Ke Chen Lina Wang Houmei Ning Huiqing Pan Weibo Zhang Weibo Zhang |
| author_facet | Ke Chen Lina Wang Houmei Ning Huiqing Pan Weibo Zhang Weibo Zhang |
| author_sort | Ke Chen |
| collection | DOAJ |
| description | ObjectiveThe present study sought to evaluate the correlation between cognitive impairment (CI) and inflammatory indicators such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammatory index (SII) in schizophrenia patients.MethodsThis study included 331 schizophrenia inpatients. General data and laboratory findings (neutrophil, lymphocyte, platelet, etc.) were gathered, and then calculating NLR, PLR, and SII. A Chinese version of the Mini Mental State Examination (MMSE) was used for the assessment of cognitive function, and then the patients in the CI group were categorized into mild CI, moderate CI, and severe CI groups. Comparing the differences in NLR, PLR, and SII between the CN group and the CI group, as well as different CI groups, and analyzing the relationship between the NLR, PLR, and SII and the mechanism of CI in schizophrenia.ResultsThere were 145 (43.8%) patients with cognitive impairment. Compared to the CN group, the CI group had higher NLR, PLR, and SII than the CN group, although their lymphocyte was lower. The NLR and SII were higher in the moderate CI group than in the mild CI group. NLR, PLR, and SII were significantly inversely correlated with the total score of cognitive function and scores across all aspects, whereas lymphocytes were considerably positively correlated. Higher NLR, PLR, and SII were substantially related to an increased risk of CI, but higher lymphocytes were associated with a decreased risk of CI.ConclusionNLR, PLR, and SII may be serum inflammatory markers of CI in schizophrenia, and lymphocytes may be protective variables for cognitive function in schizophrenia. |
| format | Article |
| id | doaj-art-a0c125cd026048b2bbfa1e760692eb13 |
| institution | OA Journals |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj-art-a0c125cd026048b2bbfa1e760692eb132025-08-20T02:09:31ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-04-011610.3389/fpsyt.2025.15524511552451Neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; systemic immune-inflammatory Index: inflammatory indicators of cognitive impairment in schizophrenia patientsKe Chen0Lina Wang1Houmei Ning2Huiqing Pan3Weibo Zhang4Weibo Zhang5Pujiang Hospital of Shanghai Mental Health Center, Minhang District Mental Health Center of Shanghai, Shanghai, ChinaPujiang Hospital of Shanghai Mental Health Center, Minhang District Mental Health Center of Shanghai, Shanghai, ChinaPujiang Hospital of Shanghai Mental Health Center, Minhang District Mental Health Center of Shanghai, Shanghai, ChinaPujiang Hospital of Shanghai Mental Health Center, Minhang District Mental Health Center of Shanghai, Shanghai, ChinaPujiang Hospital of Shanghai Mental Health Center, Minhang District Mental Health Center of Shanghai, Shanghai, ChinaShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaObjectiveThe present study sought to evaluate the correlation between cognitive impairment (CI) and inflammatory indicators such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammatory index (SII) in schizophrenia patients.MethodsThis study included 331 schizophrenia inpatients. General data and laboratory findings (neutrophil, lymphocyte, platelet, etc.) were gathered, and then calculating NLR, PLR, and SII. A Chinese version of the Mini Mental State Examination (MMSE) was used for the assessment of cognitive function, and then the patients in the CI group were categorized into mild CI, moderate CI, and severe CI groups. Comparing the differences in NLR, PLR, and SII between the CN group and the CI group, as well as different CI groups, and analyzing the relationship between the NLR, PLR, and SII and the mechanism of CI in schizophrenia.ResultsThere were 145 (43.8%) patients with cognitive impairment. Compared to the CN group, the CI group had higher NLR, PLR, and SII than the CN group, although their lymphocyte was lower. The NLR and SII were higher in the moderate CI group than in the mild CI group. NLR, PLR, and SII were significantly inversely correlated with the total score of cognitive function and scores across all aspects, whereas lymphocytes were considerably positively correlated. Higher NLR, PLR, and SII were substantially related to an increased risk of CI, but higher lymphocytes were associated with a decreased risk of CI.ConclusionNLR, PLR, and SII may be serum inflammatory markers of CI in schizophrenia, and lymphocytes may be protective variables for cognitive function in schizophrenia.https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1552451/fullcognitive impairmentneutrophil-to-lymphocyte ratioplatelet-tolymphocyte ratiosystemic immune-inflammatory indexschizophrenia |
| spellingShingle | Ke Chen Lina Wang Houmei Ning Huiqing Pan Weibo Zhang Weibo Zhang Neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; systemic immune-inflammatory Index: inflammatory indicators of cognitive impairment in schizophrenia patients Frontiers in Psychiatry cognitive impairment neutrophil-to-lymphocyte ratio platelet-tolymphocyte ratio systemic immune-inflammatory index schizophrenia |
| title | Neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; systemic immune-inflammatory Index: inflammatory indicators of cognitive impairment in schizophrenia patients |
| title_full | Neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; systemic immune-inflammatory Index: inflammatory indicators of cognitive impairment in schizophrenia patients |
| title_fullStr | Neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; systemic immune-inflammatory Index: inflammatory indicators of cognitive impairment in schizophrenia patients |
| title_full_unstemmed | Neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; systemic immune-inflammatory Index: inflammatory indicators of cognitive impairment in schizophrenia patients |
| title_short | Neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; systemic immune-inflammatory Index: inflammatory indicators of cognitive impairment in schizophrenia patients |
| title_sort | neutrophil to lymphocyte ratio platelet to lymphocyte ratio systemic immune inflammatory index inflammatory indicators of cognitive impairment in schizophrenia patients |
| topic | cognitive impairment neutrophil-to-lymphocyte ratio platelet-tolymphocyte ratio systemic immune-inflammatory index schizophrenia |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1552451/full |
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