Randomized Controlled Study Comparing Use of Propofol Plus Fentanyl versus Midazolam Plus Fentanyl as Sedation in Diagnostic Endoscopy in Patients with Advanced Liver Disease
Objectives. We aimed to investigate the safety and efficacy of propofol plus fentanyl versus midazolam plus fentanyl as sedative for patients with advanced liver disease presented for gastrointestinal endoscopy. Methods. A total of 100 patients with liver cirrhosis referred for upper endoscopy were...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2017/8462756 |
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| author | Sameh Abdelkhalik Ahmed Amal Selim Nehad Hawash Ahmed Khaled Tawfik Mohamed Yousef Abdelrahman Kobtan Rehab Badawi Sally Elnawasany Reham Abdelkader Elkhouly Amr Shaaban Hanafy Fatma H. Rizk Loai Mansour Sherief Abd-Elsalam |
| author_facet | Sameh Abdelkhalik Ahmed Amal Selim Nehad Hawash Ahmed Khaled Tawfik Mohamed Yousef Abdelrahman Kobtan Rehab Badawi Sally Elnawasany Reham Abdelkader Elkhouly Amr Shaaban Hanafy Fatma H. Rizk Loai Mansour Sherief Abd-Elsalam |
| author_sort | Sameh Abdelkhalik Ahmed |
| collection | DOAJ |
| description | Objectives. We aimed to investigate the safety and efficacy of propofol plus fentanyl versus midazolam plus fentanyl as sedative for patients with advanced liver disease presented for gastrointestinal endoscopy. Methods. A total of 100 patients with liver cirrhosis referred for upper endoscopy were enrolled and divided equally in two groups, midazolam plus fentanyl group and propofol plus fentanyl group. All patients were subjected to history taking, estimation of level of sedation, endoscopist rating, and hemodynamic parameters including oxygen saturation, heart rate, mean arterial pressure, incidence of side effect as (bradycardia, hypotension, hypoxia, nausea and vomiting, cough, shivering, or diplopia), time needed for complete recovery, and time needed for discharge. Results. There was no statistical significant difference between the studied groups regarding age, sex, weight, Child–Pugh classification score, type and duration of endoscopic intervention, time needed for complete recovery, or time needed for discharge. Complication rates were similar in both groups except for mean arterial blood pressure which was significantly lower in group of patients receiving propofol and fentanyl (P=0.001). Conclusion. The use of either propofol or midazolam in combination to fentanyl is effective in sedation of patients with advanced liver diseases presented for upper GIT endoscope. The trial is registered with ClinicalTrials.gov Identifier: NCT03063866. |
| format | Article |
| id | doaj-art-a0bc792486734b0aacaaca736a745dbb |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-a0bc792486734b0aacaaca736a745dbb2025-02-03T01:21:22ZengWileyInternational Journal of Hepatology2090-34482090-34562017-01-01201710.1155/2017/84627568462756Randomized Controlled Study Comparing Use of Propofol Plus Fentanyl versus Midazolam Plus Fentanyl as Sedation in Diagnostic Endoscopy in Patients with Advanced Liver DiseaseSameh Abdelkhalik Ahmed0Amal Selim1Nehad Hawash2Ahmed Khaled Tawfik3Mohamed Yousef4Abdelrahman Kobtan5Rehab Badawi6Sally Elnawasany7Reham Abdelkader Elkhouly8Amr Shaaban Hanafy9Fatma H. Rizk10Loai Mansour11Sherief Abd-Elsalam12Department of Anesthesia, Tanta University, Tanta, EgyptInternal Medicine Department, Tanta University, Tanta, EgyptTropical Medicine Department, Tanta University, Tanta, EgyptTropical Medicine Department, Tanta University, Tanta, EgyptTropical Medicine Department, Tanta University, Tanta, EgyptTropical Medicine Department, Tanta University, Tanta, EgyptTropical Medicine Department, Tanta University, Tanta, EgyptTropical Medicine Department, Tanta University, Tanta, EgyptTropical Medicine Department, Tanta University, Tanta, EgyptInternal Medicine Department, Zagazig University, Zagazig, EgyptDepartment of Physiology, Tanta University, Tanta, EgyptTropical Medicine Department, Tanta University, Tanta, EgyptTropical Medicine Department, Tanta University, Tanta, EgyptObjectives. We aimed to investigate the safety and efficacy of propofol plus fentanyl versus midazolam plus fentanyl as sedative for patients with advanced liver disease presented for gastrointestinal endoscopy. Methods. A total of 100 patients with liver cirrhosis referred for upper endoscopy were enrolled and divided equally in two groups, midazolam plus fentanyl group and propofol plus fentanyl group. All patients were subjected to history taking, estimation of level of sedation, endoscopist rating, and hemodynamic parameters including oxygen saturation, heart rate, mean arterial pressure, incidence of side effect as (bradycardia, hypotension, hypoxia, nausea and vomiting, cough, shivering, or diplopia), time needed for complete recovery, and time needed for discharge. Results. There was no statistical significant difference between the studied groups regarding age, sex, weight, Child–Pugh classification score, type and duration of endoscopic intervention, time needed for complete recovery, or time needed for discharge. Complication rates were similar in both groups except for mean arterial blood pressure which was significantly lower in group of patients receiving propofol and fentanyl (P=0.001). Conclusion. The use of either propofol or midazolam in combination to fentanyl is effective in sedation of patients with advanced liver diseases presented for upper GIT endoscope. The trial is registered with ClinicalTrials.gov Identifier: NCT03063866.http://dx.doi.org/10.1155/2017/8462756 |
| spellingShingle | Sameh Abdelkhalik Ahmed Amal Selim Nehad Hawash Ahmed Khaled Tawfik Mohamed Yousef Abdelrahman Kobtan Rehab Badawi Sally Elnawasany Reham Abdelkader Elkhouly Amr Shaaban Hanafy Fatma H. Rizk Loai Mansour Sherief Abd-Elsalam Randomized Controlled Study Comparing Use of Propofol Plus Fentanyl versus Midazolam Plus Fentanyl as Sedation in Diagnostic Endoscopy in Patients with Advanced Liver Disease International Journal of Hepatology |
| title | Randomized Controlled Study Comparing Use of Propofol Plus Fentanyl versus Midazolam Plus Fentanyl as Sedation in Diagnostic Endoscopy in Patients with Advanced Liver Disease |
| title_full | Randomized Controlled Study Comparing Use of Propofol Plus Fentanyl versus Midazolam Plus Fentanyl as Sedation in Diagnostic Endoscopy in Patients with Advanced Liver Disease |
| title_fullStr | Randomized Controlled Study Comparing Use of Propofol Plus Fentanyl versus Midazolam Plus Fentanyl as Sedation in Diagnostic Endoscopy in Patients with Advanced Liver Disease |
| title_full_unstemmed | Randomized Controlled Study Comparing Use of Propofol Plus Fentanyl versus Midazolam Plus Fentanyl as Sedation in Diagnostic Endoscopy in Patients with Advanced Liver Disease |
| title_short | Randomized Controlled Study Comparing Use of Propofol Plus Fentanyl versus Midazolam Plus Fentanyl as Sedation in Diagnostic Endoscopy in Patients with Advanced Liver Disease |
| title_sort | randomized controlled study comparing use of propofol plus fentanyl versus midazolam plus fentanyl as sedation in diagnostic endoscopy in patients with advanced liver disease |
| url | http://dx.doi.org/10.1155/2017/8462756 |
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