Severe childhood amitriptyline intoxication and plasmapheresis: a case report
Tricyclic antidepressant intoxication is one of the most frequently encountered and life-threatening causes of intoxication among referrals to emergency departments due to drug intoxication. There is no known antidote against any of the tricyclic antidepressants. The American Society for Aphe...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2013-12-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/1571 |
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| author | Mehmet Karacı Mustafa Özçetin Günter Dilsiz Yaşar Gözde Güçlü-Songür |
| author_facet | Mehmet Karacı Mustafa Özçetin Günter Dilsiz Yaşar Gözde Güçlü-Songür |
| author_sort | Mehmet Karacı |
| collection | DOAJ |
| description |
Tricyclic antidepressant intoxication is one of the most frequently encountered and life-threatening causes of intoxication among referrals to emergency departments due to drug intoxication. There is no known antidote against any of the tricyclic antidepressants. The American Society for Apheresis (ASFA) recommends plasmapheresis to support primary treatment in this type of drug poisoning, which does not respond to certain and traditional treatments. We present a 15-year-old girl who ingested amitriptyline with suicidal intent. On admission, she was in a comatose state (Glasgow Coma Scale score: 5), with no spontaneous respiration and presence of pathological reflexes. Due to the intake history of lethal doses and the severe clinical picture, plasmapheresis was performed. She was discharged on her fifth day of hospitalization.Due to the high plasma protein binding property of amitriptyline, plasma exchange therapy should be considered in cases of severe amitriptyline intoxication as a life-saving therapeutic modality.
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| format | Article |
| id | doaj-art-a0b84e4cf72f4ac68b108e5ed2cbad8d |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2013-12-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-a0b84e4cf72f4ac68b108e5ed2cbad8d2025-08-20T03:00:54ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212013-12-01556Severe childhood amitriptyline intoxication and plasmapheresis: a case reportMehmet Karacı0Mustafa ÖzçetinGünter DilsizYaşar Gözde Güçlü-SongürDepartment of Pediatrics Bülent Ecevit University, Faculty of Medicine, Zonguldak, Turkey. mkaraci@gmail.com. Tricyclic antidepressant intoxication is one of the most frequently encountered and life-threatening causes of intoxication among referrals to emergency departments due to drug intoxication. There is no known antidote against any of the tricyclic antidepressants. The American Society for Apheresis (ASFA) recommends plasmapheresis to support primary treatment in this type of drug poisoning, which does not respond to certain and traditional treatments. We present a 15-year-old girl who ingested amitriptyline with suicidal intent. On admission, she was in a comatose state (Glasgow Coma Scale score: 5), with no spontaneous respiration and presence of pathological reflexes. Due to the intake history of lethal doses and the severe clinical picture, plasmapheresis was performed. She was discharged on her fifth day of hospitalization.Due to the high plasma protein binding property of amitriptyline, plasma exchange therapy should be considered in cases of severe amitriptyline intoxication as a life-saving therapeutic modality. https://turkjpediatr.org/article/view/1571 |
| spellingShingle | Mehmet Karacı Mustafa Özçetin Günter Dilsiz Yaşar Gözde Güçlü-Songür Severe childhood amitriptyline intoxication and plasmapheresis: a case report The Turkish Journal of Pediatrics |
| title | Severe childhood amitriptyline intoxication and plasmapheresis: a case report |
| title_full | Severe childhood amitriptyline intoxication and plasmapheresis: a case report |
| title_fullStr | Severe childhood amitriptyline intoxication and plasmapheresis: a case report |
| title_full_unstemmed | Severe childhood amitriptyline intoxication and plasmapheresis: a case report |
| title_short | Severe childhood amitriptyline intoxication and plasmapheresis: a case report |
| title_sort | severe childhood amitriptyline intoxication and plasmapheresis a case report |
| url | https://turkjpediatr.org/article/view/1571 |
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