Primary Malignant Melanoma of the Rectum: Report of Two Cases
We report two cases of rectal malignant melanomas. The patients were an 84-year-old male and a 66-year-old female who had blood in their stools. They were preoperatively diagnosed with poorly differentiated adenocarcinoma of the rectum. The clinical diagnosis for each was rectal carcinoma at stage I...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Surgery |
| Online Access: | http://dx.doi.org/10.1155/2012/247348 |
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| author | Kodai Tomioka Hitoshi Ojima Makoto Sohda Akiko Tanabe Yasuyuki Fukai Akihiko Sano Takahiro Fukuda Masahiko Murakami |
| author_facet | Kodai Tomioka Hitoshi Ojima Makoto Sohda Akiko Tanabe Yasuyuki Fukai Akihiko Sano Takahiro Fukuda Masahiko Murakami |
| author_sort | Kodai Tomioka |
| collection | DOAJ |
| description | We report two cases of rectal malignant melanomas. The patients were an 84-year-old male and a 66-year-old female who had blood in their stools. They were preoperatively diagnosed with poorly differentiated adenocarcinoma of the rectum. The clinical diagnosis for each was rectal carcinoma at stage IIIc according to the tumor-node-metastasis classification (6th edition), and the patients underwent abdominoperineal resection with dissection of lymph nodes. Pathological examination of the resected specimens revealed a malignant melanoma. Immunohistochemical analysis results were positive for HMB-45 and negative for cytokeratin AE1/AE3, CD45, and synaptophysin. Primary anorectal melanoma is an uncommon and aggressive disease that carries a poor prognosis. Therefore, it is necessary to provide systemic treatment. To improve prognosis, it is important to detect anorectal melanoma at an early stage. |
| format | Article |
| id | doaj-art-a0b7fcd8b2664e99942502d941963b92 |
| institution | Kabale University |
| issn | 2090-6900 2090-6919 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Surgery |
| spelling | doaj-art-a0b7fcd8b2664e99942502d941963b922025-02-03T07:25:35ZengWileyCase Reports in Surgery2090-69002090-69192012-01-01201210.1155/2012/247348247348Primary Malignant Melanoma of the Rectum: Report of Two CasesKodai Tomioka0Hitoshi Ojima1Makoto Sohda2Akiko Tanabe3Yasuyuki Fukai4Akihiko Sano5Takahiro Fukuda6Masahiko Murakami7Department of Gastroenterological and General Surgery, Showa University Hospital, 1-5-8 Hatanodai, Shinagawa, Tokyo 142-8666, JapanDepartment of Gastroenterological Surgery, Gunma Prefectural Cancer Center, 617-1 Takabayashi-Nishi, Ota, Gunma 373-8550, JapanDepartment of Gastroenterological Surgery, Gunma Prefectural Cancer Center, 617-1 Takabayashi-Nishi, Ota, Gunma 373-8550, JapanDepartment of Gastroenterological Surgery, Gunma Prefectural Cancer Center, 617-1 Takabayashi-Nishi, Ota, Gunma 373-8550, JapanDepartment of Gastroenterological Surgery, Gunma Prefectural Cancer Center, 617-1 Takabayashi-Nishi, Ota, Gunma 373-8550, JapanDepartment of Gastroenterological Surgery, Gunma Prefectural Cancer Center, 617-1 Takabayashi-Nishi, Ota, Gunma 373-8550, JapanDepartment of Gastroenterological Surgery, Gunma Prefectural Cancer Center, 617-1 Takabayashi-Nishi, Ota, Gunma 373-8550, JapanDepartment of Gastroenterological and General Surgery, Showa University Hospital, 1-5-8 Hatanodai, Shinagawa, Tokyo 142-8666, JapanWe report two cases of rectal malignant melanomas. The patients were an 84-year-old male and a 66-year-old female who had blood in their stools. They were preoperatively diagnosed with poorly differentiated adenocarcinoma of the rectum. The clinical diagnosis for each was rectal carcinoma at stage IIIc according to the tumor-node-metastasis classification (6th edition), and the patients underwent abdominoperineal resection with dissection of lymph nodes. Pathological examination of the resected specimens revealed a malignant melanoma. Immunohistochemical analysis results were positive for HMB-45 and negative for cytokeratin AE1/AE3, CD45, and synaptophysin. Primary anorectal melanoma is an uncommon and aggressive disease that carries a poor prognosis. Therefore, it is necessary to provide systemic treatment. To improve prognosis, it is important to detect anorectal melanoma at an early stage.http://dx.doi.org/10.1155/2012/247348 |
| spellingShingle | Kodai Tomioka Hitoshi Ojima Makoto Sohda Akiko Tanabe Yasuyuki Fukai Akihiko Sano Takahiro Fukuda Masahiko Murakami Primary Malignant Melanoma of the Rectum: Report of Two Cases Case Reports in Surgery |
| title | Primary Malignant Melanoma of the Rectum: Report of Two Cases |
| title_full | Primary Malignant Melanoma of the Rectum: Report of Two Cases |
| title_fullStr | Primary Malignant Melanoma of the Rectum: Report of Two Cases |
| title_full_unstemmed | Primary Malignant Melanoma of the Rectum: Report of Two Cases |
| title_short | Primary Malignant Melanoma of the Rectum: Report of Two Cases |
| title_sort | primary malignant melanoma of the rectum report of two cases |
| url | http://dx.doi.org/10.1155/2012/247348 |
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