Inсretin-based therapy in patients with type 2 diabetes and chronic kidney disease
The program of renoprotection in patients with diabetes mellitus (DM) is based on a conceptual model of development and progressionof diabetic kidney disease, which is the result of combined impact of genetically modulated metabolic and hemodynamic factors. Compensationof carbohydrate metabolism, wh...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2012-09-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/6087 |
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| author | Minara Shamkhalovna Shamkhalova Marina Vladimirovna Shestakova |
| author_facet | Minara Shamkhalovna Shamkhalova Marina Vladimirovna Shestakova |
| author_sort | Minara Shamkhalovna Shamkhalova |
| collection | DOAJ |
| description | The program of renoprotection in patients with diabetes mellitus (DM) is based on a conceptual model of development and progressionof diabetic kidney disease, which is the result of combined impact of genetically modulated metabolic and hemodynamic factors. Compensationof carbohydrate metabolism, which is crucial at the clinical debut of nephropathy, becomes problematic at the late stages ofchronic kidney disease (CKD). ADA (American Diabetes Association) and EASD (European Association for the Study of Diabetes)recommendations formalized in a consensus on the treatment of patients with type 2 diabetes (T2D) should only be extrapolated topatients with CKD with great prudence. Incretin-based drugs gain reputation as promising and perspective therapy for metabolic controlin patients with type 2 DM and CKD. There is an obvious need for large-scale, long-term studies involving patients with various severityof renal disease and related complications to assess the potential of this new diabetes therapy trend. |
| format | Article |
| id | doaj-art-a0b7dc2b00c94888a3ecc8ecad6405f8 |
| institution | DOAJ |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2012-09-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-a0b7dc2b00c94888a3ecc8ecad6405f82025-08-20T03:09:04ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782012-09-01153596610.14341/2072-0351-60876045Inсretin-based therapy in patients with type 2 diabetes and chronic kidney diseaseMinara Shamkhalovna Shamkhalova0Marina Vladimirovna Shestakova1Endocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowThe program of renoprotection in patients with diabetes mellitus (DM) is based on a conceptual model of development and progressionof diabetic kidney disease, which is the result of combined impact of genetically modulated metabolic and hemodynamic factors. Compensationof carbohydrate metabolism, which is crucial at the clinical debut of nephropathy, becomes problematic at the late stages ofchronic kidney disease (CKD). ADA (American Diabetes Association) and EASD (European Association for the Study of Diabetes)recommendations formalized in a consensus on the treatment of patients with type 2 diabetes (T2D) should only be extrapolated topatients with CKD with great prudence. Incretin-based drugs gain reputation as promising and perspective therapy for metabolic controlin patients with type 2 DM and CKD. There is an obvious need for large-scale, long-term studies involving patients with various severityof renal disease and related complications to assess the potential of this new diabetes therapy trend.https://www.dia-endojournals.ru/jour/article/view/6087diabetes mellituschronic kidney diseasediabetic nephropathyincretin-based therapy |
| spellingShingle | Minara Shamkhalovna Shamkhalova Marina Vladimirovna Shestakova Inсretin-based therapy in patients with type 2 diabetes and chronic kidney disease Сахарный диабет diabetes mellitus chronic kidney disease diabetic nephropathy incretin-based therapy |
| title | Inсretin-based therapy in patients with type 2 diabetes and chronic kidney disease |
| title_full | Inсretin-based therapy in patients with type 2 diabetes and chronic kidney disease |
| title_fullStr | Inсretin-based therapy in patients with type 2 diabetes and chronic kidney disease |
| title_full_unstemmed | Inсretin-based therapy in patients with type 2 diabetes and chronic kidney disease |
| title_short | Inсretin-based therapy in patients with type 2 diabetes and chronic kidney disease |
| title_sort | inсretin based therapy in patients with type 2 diabetes and chronic kidney disease |
| topic | diabetes mellitus chronic kidney disease diabetic nephropathy incretin-based therapy |
| url | https://www.dia-endojournals.ru/jour/article/view/6087 |
| work_keys_str_mv | AT minarashamkhalovnashamkhalova insretinbasedtherapyinpatientswithtype2diabetesandchronickidneydisease AT marinavladimirovnashestakova insretinbasedtherapyinpatientswithtype2diabetesandchronickidneydisease |