Self-modulating therapeutic platform using engineered miRNA-responsive oligonucleotides

Self-modulating therapeutic platform using engineered miRNA-responsive oligonucleotides

Abstract Due to a pivotal role in the post-transcriptional regulation of genes implicated in numerous diseases, miRNAs serve as promising disease biomarkers and therapeutic targets. We introduce a new oligonucleotide probe termed miRNA-trigger, which selectively downregulates newly assigned target m...

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Bibliographic Details
Main Authors: Doyeong Ku, Hansol Kim, JinA Lim, Jayeon Song, Junhyeok Yoon, Liu Jun, Su-Ji Min, Ryeongeun Cho, Namseok Lee, Kyunghoon Hur, Jong-Eun Park, Luke P. Lee, Junshik Hong, Yoosik Kim, Hyun Gyu Park
Format: Article
Language:English
Published: SpringerOpen 2025-06-01
Series:Nano Convergence
Subjects:
miRNAs
Apoptosis induction
Gene regulation
BCL-xL gene
Oligonucleotide therapy
Online Access:https://doi.org/10.1186/s40580-025-00499-w
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