Toxicology and Biodegradability of a Phthalate-Free and Bio-Based Novel Plasticizer
Phthalate esters, mainly di-ethylhexylphthalate (DEHP), represent a class of chemicals primarily used as plasticizers for polyvinyl chloride in a wide range of domestic and industrial applications. These phthalate esters are low-toxicity environmental contaminants. To address these drawbacks, POLYSO...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2021/9970896 |
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| author | S. Simar-Mentières F. Nesslany M.-L. Sola S. Mortier J.-M. Raimbault F. Gondelle L. Chabot P. Pandard D. Wils A. Chentouf |
| author_facet | S. Simar-Mentières F. Nesslany M.-L. Sola S. Mortier J.-M. Raimbault F. Gondelle L. Chabot P. Pandard D. Wils A. Chentouf |
| author_sort | S. Simar-Mentières |
| collection | DOAJ |
| description | Phthalate esters, mainly di-ethylhexylphthalate (DEHP), represent a class of chemicals primarily used as plasticizers for polyvinyl chloride in a wide range of domestic and industrial applications. These phthalate esters are low-toxicity environmental contaminants. To address these drawbacks, POLYSORB® ID 37, a blend of diesters obtained from esterification of isosorbide with plant-based fatty acids, was developed. The company can now offer PVC manufacturers a new product which competes with phthalates and other such chemicals. The market for plasticizers is very important, and ROQUETTE intends to provide a more sustainable and safer product. Isosorbide diester is bio-based (made from glucose and vegetable fatty acids). This plasticizer is registered in REACH regulation for high volumes (>1000 T/year). Risk assessment was obtained by conducting a wide range of biodegradability and toxicological protocols, using rodent models, according to established guidelines. Overall, all of the toxicological and biodegradability studies demonstrated that POLYSORB® ID 37 is nontoxic to mammalian life and is readily biodegradable. |
| format | Article |
| id | doaj-art-a0b17d7471dc4f6daf7f3ee6cf0e7009 |
| institution | OA Journals |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-a0b17d7471dc4f6daf7f3ee6cf0e70092025-08-20T02:20:55ZengWileyJournal of Toxicology1687-81911687-82052021-01-01202110.1155/2021/99708969970896Toxicology and Biodegradability of a Phthalate-Free and Bio-Based Novel PlasticizerS. Simar-Mentières0F. Nesslany1M.-L. Sola2S. Mortier3J.-M. Raimbault4F. Gondelle5L. Chabot6P. Pandard7D. Wils8A. Chentouf9Institut Pasteur de Lille-Laboratoire de Toxicologie Génétique, 1 Rue Du Pr. Calmette, Lille Cedex 59019, FranceInstitut Pasteur de Lille-Laboratoire de Toxicologie Génétique, 1 Rue Du Pr. Calmette, Lille Cedex 59019, FranceERBC, Chemin de Montifault, Baugy 18800, FranceERBC, Chemin de Montifault, Baugy 18800, FranceERBC, Chemin de Montifault, Baugy 18800, FranceIneris-Direction des Risques Chroniques, Pôle VIVA, Unité EXES–Parc Technologique ALATA. BP 2, Verneuil-en Halatte 60550, FranceIneris-Direction des Risques Chroniques, Pôle VIVA, Unité EXES–Parc Technologique ALATA. BP 2, Verneuil-en Halatte 60550, FranceIneris-Direction des Risques Chroniques, Pôle VIVA, Unité EXES–Parc Technologique ALATA. BP 2, Verneuil-en Halatte 60550, FranceRoquette Frères, Toxicology & Safety Unit-Nutrition & Health R&D, 1, Rue de La Haute Loge, Lestrem 62136, FranceRoquette Frères, Toxicology & Safety Unit-Nutrition & Health R&D, 1, Rue de La Haute Loge, Lestrem 62136, FrancePhthalate esters, mainly di-ethylhexylphthalate (DEHP), represent a class of chemicals primarily used as plasticizers for polyvinyl chloride in a wide range of domestic and industrial applications. These phthalate esters are low-toxicity environmental contaminants. To address these drawbacks, POLYSORB® ID 37, a blend of diesters obtained from esterification of isosorbide with plant-based fatty acids, was developed. The company can now offer PVC manufacturers a new product which competes with phthalates and other such chemicals. The market for plasticizers is very important, and ROQUETTE intends to provide a more sustainable and safer product. Isosorbide diester is bio-based (made from glucose and vegetable fatty acids). This plasticizer is registered in REACH regulation for high volumes (>1000 T/year). Risk assessment was obtained by conducting a wide range of biodegradability and toxicological protocols, using rodent models, according to established guidelines. Overall, all of the toxicological and biodegradability studies demonstrated that POLYSORB® ID 37 is nontoxic to mammalian life and is readily biodegradable.http://dx.doi.org/10.1155/2021/9970896 |
| spellingShingle | S. Simar-Mentières F. Nesslany M.-L. Sola S. Mortier J.-M. Raimbault F. Gondelle L. Chabot P. Pandard D. Wils A. Chentouf Toxicology and Biodegradability of a Phthalate-Free and Bio-Based Novel Plasticizer Journal of Toxicology |
| title | Toxicology and Biodegradability of a Phthalate-Free and Bio-Based Novel Plasticizer |
| title_full | Toxicology and Biodegradability of a Phthalate-Free and Bio-Based Novel Plasticizer |
| title_fullStr | Toxicology and Biodegradability of a Phthalate-Free and Bio-Based Novel Plasticizer |
| title_full_unstemmed | Toxicology and Biodegradability of a Phthalate-Free and Bio-Based Novel Plasticizer |
| title_short | Toxicology and Biodegradability of a Phthalate-Free and Bio-Based Novel Plasticizer |
| title_sort | toxicology and biodegradability of a phthalate free and bio based novel plasticizer |
| url | http://dx.doi.org/10.1155/2021/9970896 |
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