Methylation risk score of C-reactive protein associates sleep health with related health outcomes
Abstract C-reactive protein (CRP) reflects inflammation status and is linked to poor sleep, metabolic and cardiovascular health. Methylation (MRS) and polygenic risk scores (PRS) reflect long-term systemic inflammation, and genetically-determined CRP, respectively. To refine understanding of inflamm...
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Nature Portfolio
2025-05-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-08226-1 |
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| author | Ziqing Wang Danielle A. Wallace Brian W. Spitzer Tianyi Huang Kent D. Taylor Jerome I. Rotter Stephen S. Rich Peter Y. Liu Martha L. Daviglus Lifang Hou Alberto R. Ramos Sonya Kaur J. Peter Durda Hector M. González Myriam Fornage Susan Redline Carmen R. Isasi Tamar Sofer |
| author_facet | Ziqing Wang Danielle A. Wallace Brian W. Spitzer Tianyi Huang Kent D. Taylor Jerome I. Rotter Stephen S. Rich Peter Y. Liu Martha L. Daviglus Lifang Hou Alberto R. Ramos Sonya Kaur J. Peter Durda Hector M. González Myriam Fornage Susan Redline Carmen R. Isasi Tamar Sofer |
| author_sort | Ziqing Wang |
| collection | DOAJ |
| description | Abstract C-reactive protein (CRP) reflects inflammation status and is linked to poor sleep, metabolic and cardiovascular health. Methylation (MRS) and polygenic risk scores (PRS) reflect long-term systemic inflammation, and genetically-determined CRP, respectively. To refine understanding of inflammation-linked sleep and health outcomes, we construct PRS-CRPs using GWAS summary statistics and a previously-developed MRS-CRP in the Hispanic Community Health Study/Study of Latinos. Via survey-weighted linear regression, we estimate associations between blood-, PRS-, and MRS-CRP, with multiple sleep and health outcomes (n = 2217). MRS-CRP and PRS-CRPs are associated with increasing blood-CRP level by 43% and 23% per standard deviation. MRS-CRP is associated with obstructive sleep apnea (OSA) traits, long sleep duration, diabetes and hypertension, while PRS-CRPs were not. Blood-CRP level is associated with sleep duration and diabetes. Adjusting for MRS-CRP weakens OSA-diabetes/hypertension associations. Consequently, MRS-CRP is a stronger marker than blood-CRP and PRS-CRP to systemic inflammation associated with poor sleep and related comorbidities. |
| format | Article |
| id | doaj-art-a0affb339ece4d83936c4bae86b1045b |
| institution | DOAJ |
| issn | 2399-3642 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-a0affb339ece4d83936c4bae86b1045b2025-08-20T03:22:12ZengNature PortfolioCommunications Biology2399-36422025-05-018111110.1038/s42003-025-08226-1Methylation risk score of C-reactive protein associates sleep health with related health outcomesZiqing Wang0Danielle A. Wallace1Brian W. Spitzer2Tianyi Huang3Kent D. Taylor4Jerome I. Rotter5Stephen S. Rich6Peter Y. Liu7Martha L. Daviglus8Lifang Hou9Alberto R. Ramos10Sonya Kaur11J. Peter Durda12Hector M. González13Myriam Fornage14Susan Redline15Carmen R. Isasi16Tamar Sofer17Cardiovascular Institute, Beth Israel Deaconess Medical CenterCardiovascular Institute, Beth Israel Deaconess Medical CenterCardiovascular Institute, Beth Israel Deaconess Medical CenterLaboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on AgingThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical CenterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical CenterDepartment of Genome Sciences, University of Virginia School of MedicineDivision of Genetics, Lundquist Institute at Harbor-UCLA Medical CenterDepartment of Preventive Medicine, Northwestern University Feinberg School of MedicineDepartment of Preventive Medicine, Northwestern University Feinberg School of MedicineDepartment of Neurology, University of Miami Miller School of MedicineDepartment of Neurology, University of Miami Miller School of MedicineDepartment of Pathology and Laboratory Medicine, University of VermontDepartment of Neurosciences and Shiley-Marcos Alzheimer’s Disease Center, University of California, San DiegoHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at HoustonDepartment of Medicine, Harvard Medical SchoolDepartment of Epidemiology & Population Health, Department of Pediatrics, Albert Einstein College of MedicineCardiovascular Institute, Beth Israel Deaconess Medical CenterAbstract C-reactive protein (CRP) reflects inflammation status and is linked to poor sleep, metabolic and cardiovascular health. Methylation (MRS) and polygenic risk scores (PRS) reflect long-term systemic inflammation, and genetically-determined CRP, respectively. To refine understanding of inflammation-linked sleep and health outcomes, we construct PRS-CRPs using GWAS summary statistics and a previously-developed MRS-CRP in the Hispanic Community Health Study/Study of Latinos. Via survey-weighted linear regression, we estimate associations between blood-, PRS-, and MRS-CRP, with multiple sleep and health outcomes (n = 2217). MRS-CRP and PRS-CRPs are associated with increasing blood-CRP level by 43% and 23% per standard deviation. MRS-CRP is associated with obstructive sleep apnea (OSA) traits, long sleep duration, diabetes and hypertension, while PRS-CRPs were not. Blood-CRP level is associated with sleep duration and diabetes. Adjusting for MRS-CRP weakens OSA-diabetes/hypertension associations. Consequently, MRS-CRP is a stronger marker than blood-CRP and PRS-CRP to systemic inflammation associated with poor sleep and related comorbidities.https://doi.org/10.1038/s42003-025-08226-1 |
| spellingShingle | Ziqing Wang Danielle A. Wallace Brian W. Spitzer Tianyi Huang Kent D. Taylor Jerome I. Rotter Stephen S. Rich Peter Y. Liu Martha L. Daviglus Lifang Hou Alberto R. Ramos Sonya Kaur J. Peter Durda Hector M. González Myriam Fornage Susan Redline Carmen R. Isasi Tamar Sofer Methylation risk score of C-reactive protein associates sleep health with related health outcomes Communications Biology |
| title | Methylation risk score of C-reactive protein associates sleep health with related health outcomes |
| title_full | Methylation risk score of C-reactive protein associates sleep health with related health outcomes |
| title_fullStr | Methylation risk score of C-reactive protein associates sleep health with related health outcomes |
| title_full_unstemmed | Methylation risk score of C-reactive protein associates sleep health with related health outcomes |
| title_short | Methylation risk score of C-reactive protein associates sleep health with related health outcomes |
| title_sort | methylation risk score of c reactive protein associates sleep health with related health outcomes |
| url | https://doi.org/10.1038/s42003-025-08226-1 |
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