Modulation of Toll-Like Receptor Activity by Leukocyte Ig-Like Receptors and Their Effects during Bacterial Infection
Toll-like receptors (TLRs) are a potent trigger for inflammatory immune responses. Without tight regulation their activation could lead to pathology, so it is imperative to extend our understanding of the regulatory mechanisms that govern TLR expression and function. One family of immunoregulatory...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/536478 |
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| author | Louise E. Pilsbury Rachel L. Allen Martin Vordermeier |
| author_facet | Louise E. Pilsbury Rachel L. Allen Martin Vordermeier |
| author_sort | Louise E. Pilsbury |
| collection | DOAJ |
| description | Toll-like receptors (TLRs) are a potent trigger for inflammatory immune responses. Without tight regulation their activation could lead to pathology, so it is imperative to extend our understanding of the regulatory mechanisms that govern TLR expression and function. One family of immunoregulatory proteins which can provide a balancing effect on TLR activity are the Leukocyte Ig-like receptors (LILRs), which act as innate immune receptors for self-proteins. Here we describe the LILR family, their inhibitory effect on TLR activity in cells of the monocytic lineage, their signalling pathway, and their antimicrobial effects during bacterial infection. Agents have already been identified which enhances or inhibits LILR activity raising the future possibility that modulation of LILR function could be used as a means to modulate TLR activity. |
| format | Article |
| id | doaj-art-a0a261095737416297e7fc454242d9e7 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-a0a261095737416297e7fc454242d9e72025-02-03T06:07:03ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/536478536478Modulation of Toll-Like Receptor Activity by Leukocyte Ig-Like Receptors and Their Effects during Bacterial InfectionLouise E. Pilsbury0Rachel L. Allen1Martin Vordermeier2Centre for Infection, St George's University of London, Cranmer Terrace, London SW17 0RE, UKCentre for Infection, St George's University of London, Cranmer Terrace, London SW17 0RE, UKVeterinary Laboratories Agency, Weybridge, New Haw, KT15 3NB, UKToll-like receptors (TLRs) are a potent trigger for inflammatory immune responses. Without tight regulation their activation could lead to pathology, so it is imperative to extend our understanding of the regulatory mechanisms that govern TLR expression and function. One family of immunoregulatory proteins which can provide a balancing effect on TLR activity are the Leukocyte Ig-like receptors (LILRs), which act as innate immune receptors for self-proteins. Here we describe the LILR family, their inhibitory effect on TLR activity in cells of the monocytic lineage, their signalling pathway, and their antimicrobial effects during bacterial infection. Agents have already been identified which enhances or inhibits LILR activity raising the future possibility that modulation of LILR function could be used as a means to modulate TLR activity.http://dx.doi.org/10.1155/2010/536478 |
| spellingShingle | Louise E. Pilsbury Rachel L. Allen Martin Vordermeier Modulation of Toll-Like Receptor Activity by Leukocyte Ig-Like Receptors and Their Effects during Bacterial Infection Mediators of Inflammation |
| title | Modulation of Toll-Like Receptor Activity by Leukocyte Ig-Like Receptors and Their Effects during Bacterial Infection |
| title_full | Modulation of Toll-Like Receptor Activity by Leukocyte Ig-Like Receptors and Their Effects during Bacterial Infection |
| title_fullStr | Modulation of Toll-Like Receptor Activity by Leukocyte Ig-Like Receptors and Their Effects during Bacterial Infection |
| title_full_unstemmed | Modulation of Toll-Like Receptor Activity by Leukocyte Ig-Like Receptors and Their Effects during Bacterial Infection |
| title_short | Modulation of Toll-Like Receptor Activity by Leukocyte Ig-Like Receptors and Their Effects during Bacterial Infection |
| title_sort | modulation of toll like receptor activity by leukocyte ig like receptors and their effects during bacterial infection |
| url | http://dx.doi.org/10.1155/2010/536478 |
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