Exploring the antimicrobial potential of the articaine derivative in oral infections
Objective Postoperative infection is one of the most common complications in dental procedures. During local anesthesia in dental treatments, the risk of postoperative infections increases if the oral mucosa is infected, the anesthesia injection site is inadequately disinfected, or the injection nee...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Journal of Oral Microbiology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/20002297.2025.2502455 |
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| author | Yongzhen Tan Yihang Hao Yihang Fu Shilong Hu Xi Yang Yaling Tang Bowen Ke Xinhua Liang |
| author_facet | Yongzhen Tan Yihang Hao Yihang Fu Shilong Hu Xi Yang Yaling Tang Bowen Ke Xinhua Liang |
| author_sort | Yongzhen Tan |
| collection | DOAJ |
| description | Objective Postoperative infection is one of the most common complications in dental procedures. During local anesthesia in dental treatments, the risk of postoperative infections increases if the oral mucosa is infected, the anesthesia injection site is inadequately disinfected, or the injection needle and anesthetic drugs are contaminated. Thus, developing new oral local anesthetics that offer superior anesthesia, enhanced safety, and antimicrobial properties could greatly enhance their clinical value.Methods The anesthetic effects and antibacterial properties of articaine derivatives were screened using membrane chromatography techniques, animal experiments, and cellular molecular assays. Safety assessments were conducted on the selected target compounds. Additionally, the antibacterial mechanisms of the compounds were investigated through molecular dynamics simulations and cryo-electron microscopy.Results Through the screening of articaine derivatives, a novel local anesthetic, AT-15, was identified, which combines effective anesthetic properties with antibacterial activity. This compound exhibits strong pharmacological activity and high safety. Its antibacterial effect is believed to result from the disruption of bacterial cell membranes and the inhibition of topoisomerase, an enzyme essential for bacterial DNA synthesis.Conclusion AT-15 discovered in this study is a promising candidate for further development in clinical settings. |
| format | Article |
| id | doaj-art-a09f48fd2f584209af5e7608d750b7b0 |
| institution | OA Journals |
| issn | 2000-2297 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Oral Microbiology |
| spelling | doaj-art-a09f48fd2f584209af5e7608d750b7b02025-08-20T01:49:43ZengTaylor & Francis GroupJournal of Oral Microbiology2000-22972025-12-0117110.1080/20002297.2025.2502455Exploring the antimicrobial potential of the articaine derivative in oral infectionsYongzhen Tan0Yihang Hao1Yihang Fu2Shilong Hu3Xi Yang4Yaling Tang5Bowen Ke6Xinhua Liang7State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaDepartment of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Anesthesiology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaDepartment of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaObjective Postoperative infection is one of the most common complications in dental procedures. During local anesthesia in dental treatments, the risk of postoperative infections increases if the oral mucosa is infected, the anesthesia injection site is inadequately disinfected, or the injection needle and anesthetic drugs are contaminated. Thus, developing new oral local anesthetics that offer superior anesthesia, enhanced safety, and antimicrobial properties could greatly enhance their clinical value.Methods The anesthetic effects and antibacterial properties of articaine derivatives were screened using membrane chromatography techniques, animal experiments, and cellular molecular assays. Safety assessments were conducted on the selected target compounds. Additionally, the antibacterial mechanisms of the compounds were investigated through molecular dynamics simulations and cryo-electron microscopy.Results Through the screening of articaine derivatives, a novel local anesthetic, AT-15, was identified, which combines effective anesthetic properties with antibacterial activity. This compound exhibits strong pharmacological activity and high safety. Its antibacterial effect is believed to result from the disruption of bacterial cell membranes and the inhibition of topoisomerase, an enzyme essential for bacterial DNA synthesis.Conclusion AT-15 discovered in this study is a promising candidate for further development in clinical settings.https://www.tandfonline.com/doi/10.1080/20002297.2025.2502455Local dental anestheticsarticainecell membrane chromatographyantibacterial activitysafety evaluation |
| spellingShingle | Yongzhen Tan Yihang Hao Yihang Fu Shilong Hu Xi Yang Yaling Tang Bowen Ke Xinhua Liang Exploring the antimicrobial potential of the articaine derivative in oral infections Journal of Oral Microbiology Local dental anesthetics articaine cell membrane chromatography antibacterial activity safety evaluation |
| title | Exploring the antimicrobial potential of the articaine derivative in oral infections |
| title_full | Exploring the antimicrobial potential of the articaine derivative in oral infections |
| title_fullStr | Exploring the antimicrobial potential of the articaine derivative in oral infections |
| title_full_unstemmed | Exploring the antimicrobial potential of the articaine derivative in oral infections |
| title_short | Exploring the antimicrobial potential of the articaine derivative in oral infections |
| title_sort | exploring the antimicrobial potential of the articaine derivative in oral infections |
| topic | Local dental anesthetics articaine cell membrane chromatography antibacterial activity safety evaluation |
| url | https://www.tandfonline.com/doi/10.1080/20002297.2025.2502455 |
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