Association between serum tricosanoic acid and cognitive function in older adults: findings from the NHANES and GEO databases
IntroductionWith global aging, dementia prevalence rises. While long-chain saturated fatty acids show anti-cognitive decline potential, serum tricosanoic acid (C23:0)’s role in brain regions and cognition remains unclear.MethodsTo confirm the association between C23:0 and cognition in the population...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1534303/full |
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| author | Ti Yang Yue Zhang Zeen Cai Ying Wang Shengqiong Deng |
| author_facet | Ti Yang Yue Zhang Zeen Cai Ying Wang Shengqiong Deng |
| author_sort | Ti Yang |
| collection | DOAJ |
| description | IntroductionWith global aging, dementia prevalence rises. While long-chain saturated fatty acids show anti-cognitive decline potential, serum tricosanoic acid (C23:0)’s role in brain regions and cognition remains unclear.MethodsTo confirm the association between C23:0 and cognition in the population, we analyzed gene expression data from the Alzheimer’s disease (AD) brain gene chip data set (GSE118553) available in the Gene Expression Omnibus (GEO) database. Additionally, we examined data from 1,127 adults aged 60 years and older who participated in the National Health and Nutrition Examination Survey (NHANES) between 2011 and 2014. To explore potential metabolic pathways and mechanisms linking C23:0 to cognitive aging, the computational platform METAFlux was employed.ResultsDifferential gene expression analysis identified 335 downregulated and 477 upregulated genes in AD frontal cortex. Metabolite analysis showed 20 upregulated and 37 downregulated nutrients (including C23:0) in AD vs. controls. Population-level analysis (NHANES, n = 1,127) confirmed higher serum C23:0 associated with better cognitive function.DiscussionThis study provides strong evidence for frontal cortex-specific reduced C23:0 in AD and highlights its potential as a serum cognitive marker. |
| format | Article |
| id | doaj-art-a093151eba844eee9742b6323bdb60ec |
| institution | OA Journals |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-a093151eba844eee9742b6323bdb60ec2025-08-20T01:49:28ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-03-011710.3389/fnagi.2025.15343031534303Association between serum tricosanoic acid and cognitive function in older adults: findings from the NHANES and GEO databasesTi Yang0Yue Zhang1Zeen Cai2Ying Wang3Shengqiong Deng4Department of Clinical Pharmacy, Gongli Hospital of Shanghai Pudong New Area, Shanghai, ChinaDepartment of Clinical Pharmacy, Jimo People’s Hospital, Qingdao, Shandong, ChinaSchool of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology, Shanghai, ChinaShanghai Health Commission Key Lab of Artificial Intelligence (AI)-Based Management of Inflammation and Chronic Diseases, Department of Clinical Laboratory, Gongli Hospital of Shanghai Pudong New Area, Shanghai, ChinaShanghai Health Commission Key Lab of Artificial Intelligence (AI)-Based Management of Inflammation and Chronic Diseases, Department of Clinical Laboratory, Gongli Hospital of Shanghai Pudong New Area, Shanghai, ChinaIntroductionWith global aging, dementia prevalence rises. While long-chain saturated fatty acids show anti-cognitive decline potential, serum tricosanoic acid (C23:0)’s role in brain regions and cognition remains unclear.MethodsTo confirm the association between C23:0 and cognition in the population, we analyzed gene expression data from the Alzheimer’s disease (AD) brain gene chip data set (GSE118553) available in the Gene Expression Omnibus (GEO) database. Additionally, we examined data from 1,127 adults aged 60 years and older who participated in the National Health and Nutrition Examination Survey (NHANES) between 2011 and 2014. To explore potential metabolic pathways and mechanisms linking C23:0 to cognitive aging, the computational platform METAFlux was employed.ResultsDifferential gene expression analysis identified 335 downregulated and 477 upregulated genes in AD frontal cortex. Metabolite analysis showed 20 upregulated and 37 downregulated nutrients (including C23:0) in AD vs. controls. Population-level analysis (NHANES, n = 1,127) confirmed higher serum C23:0 associated with better cognitive function.DiscussionThis study provides strong evidence for frontal cortex-specific reduced C23:0 in AD and highlights its potential as a serum cognitive marker.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1534303/fullAlzheimer’s disease (AD)tricosanoic acidGEONHANESolder adults |
| spellingShingle | Ti Yang Yue Zhang Zeen Cai Ying Wang Shengqiong Deng Association between serum tricosanoic acid and cognitive function in older adults: findings from the NHANES and GEO databases Frontiers in Aging Neuroscience Alzheimer’s disease (AD) tricosanoic acid GEO NHANES older adults |
| title | Association between serum tricosanoic acid and cognitive function in older adults: findings from the NHANES and GEO databases |
| title_full | Association between serum tricosanoic acid and cognitive function in older adults: findings from the NHANES and GEO databases |
| title_fullStr | Association between serum tricosanoic acid and cognitive function in older adults: findings from the NHANES and GEO databases |
| title_full_unstemmed | Association between serum tricosanoic acid and cognitive function in older adults: findings from the NHANES and GEO databases |
| title_short | Association between serum tricosanoic acid and cognitive function in older adults: findings from the NHANES and GEO databases |
| title_sort | association between serum tricosanoic acid and cognitive function in older adults findings from the nhanes and geo databases |
| topic | Alzheimer’s disease (AD) tricosanoic acid GEO NHANES older adults |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1534303/full |
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