Impact of age and sex on survival outcomes in patients aged 1-45 years with acute lymphoblastic leukemia treated according to the stratification used in the NOPHO ALL2008 trial
Age and sex have historically been associated with differences in acute lymphoblastic leukemia (ALL) survival. In the NOPHO ALL2008 trial, patients aged 1-45 years with BCR::ABL1-negative B-precursor and Tcell ALL were included, but neither sex nor age was integrated into risk group allocation. Amo...
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Ferrata Storti Foundation
2025-02-01
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| Series: | Haematologica |
| Online Access: | https://haematologica.org/article/view/11948 |
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| author | Tuomas Lahteenmaki Taalas Trausti Oskarsson Mats Heyman Bendik Lund Kristi Lepik Goda Vaitkevičiene Olafur Gisli Jonsson Julia Eriksson Nina Toft Laimonas Griškevičius Helene Hallbook Katrin Palk Ulla Wartiovaara-Kautto Petter Quist-Paulsen Ulrika Noren-Nystrom Kim Vettenranta Jonas Abrahamsson Kjeld Schmiegelow Paivi M Lahteenmaki |
| author_facet | Tuomas Lahteenmaki Taalas Trausti Oskarsson Mats Heyman Bendik Lund Kristi Lepik Goda Vaitkevičiene Olafur Gisli Jonsson Julia Eriksson Nina Toft Laimonas Griškevičius Helene Hallbook Katrin Palk Ulla Wartiovaara-Kautto Petter Quist-Paulsen Ulrika Noren-Nystrom Kim Vettenranta Jonas Abrahamsson Kjeld Schmiegelow Paivi M Lahteenmaki |
| author_sort | Tuomas Lahteenmaki Taalas |
| collection | DOAJ |
| description |
Age and sex have historically been associated with differences in acute lymphoblastic leukemia (ALL) survival. In the NOPHO ALL2008 trial, patients aged 1-45 years with BCR::ABL1-negative B-precursor and Tcell ALL were included, but neither sex nor age was integrated into risk group allocation. Among 1,771 trial patients stratified into protocol-appropriate risk groups, we estimated the impact of age and sex on survival (even after relapse) and toxicities prospectively registered at three-month intervals.
In multivariate Cox regression analysis adjusted by sex, age group, and risk group, age but not sex was an independent risk factor for reduced 5-year event-free survival (EFS), hazard ratio 1.57 (95%CI 1.15-2.14) for patients 10-17.9 years, and 2.70 (2.03-3.58) for patients 18-45 years, compared to patients |
| format | Article |
| id | doaj-art-a092caad419c435a9e243a08512faef4 |
| institution | OA Journals |
| issn | 0390-6078 1592-8721 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Ferrata Storti Foundation |
| record_format | Article |
| series | Haematologica |
| spelling | doaj-art-a092caad419c435a9e243a08512faef42025-08-20T02:14:37ZengFerrata Storti FoundationHaematologica0390-60781592-87212025-02-01999110.3324/haematol.2024.286043Impact of age and sex on survival outcomes in patients aged 1-45 years with acute lymphoblastic leukemia treated according to the stratification used in the NOPHO ALL2008 trialTuomas Lahteenmaki Taalas0Trausti Oskarsson1Mats Heyman2Bendik Lund3Kristi Lepik4Goda Vaitkevičiene5Olafur Gisli Jonsson6Julia Eriksson7Nina Toft8Laimonas Griškevičius9Helene Hallbook10Katrin Palk11Ulla Wartiovaara-Kautto12Petter Quist-Paulsen13Ulrika Noren-Nystrom14Kim Vettenranta15Jonas Abrahamsson16Kjeld Schmiegelow17Paivi M Lahteenmaki18Department of Pediatric and Adolescent Medicine, Turku University Hospital, FICAN-West, and Turku University, TurkuDepartment of Paediatric Oncology, Astrid Lindgren Children's Hospital, Stockholm, Sweden; Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, StockholmDepartment of Paediatric Oncology, Astrid Lindgren Children's Hospital, Stockholm, Sweden; Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, StockholmDepartment of Pediatrics, St. Olavs Hospital, TrondheimTallinn Children’s Hospital, Tallinn, EstoniaCentre for Pediatric Oncology and Hematology, Children’s Hospital, Affiliate of Vilnius University Hospital Santariskiu Klinikos, Vilnius, LithuaniaChildren's Hospital, Landspitali University Hospital, ReykjavikDivision of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, StockholmDepartment of Hematology, University Hospital Rigshospitalet, CopenhagenHematology, Oncology and Transfusion Medicine Center Vilnius University Hospital Santaros Klinikos, Vilnius University, Vilnius, LithuaniaDepartment of Medical Sciences, Uppsala University, UppsalaDepartment of Hematology, North Estonia Medical Centre, Tallinn, EstoniaDepartment of Hematology, Helsinki University Hospital Comprehensive Cancer Center and University of Helsinki, HelsinkiDepartment of Hematology, St. Olav’s Hospital, Trondheim University Hospital, TrondheimDepartment of Clinical Sciences, Pediatrics, Umea University, UmeaDivision of Pediatric Hematology-Oncology and Stem Cell Transplantation, Helsinki University Central Hospital, HelsinkiChildren’s Cancer Center, Department of Pediatrics, Sahlgrenska University Hospital, GoteborgDepartment of Pediatrics and Adolescent Medicine, Rishospitalet University Hospital and Institute of Clinical Medicine, Faculty of Medicine, University of CopenhagenDepartment of Pediatric and Adolescent Medicine, Turku University Hospital, FICAN-West, and Turku University, Turku, Finland; Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm Age and sex have historically been associated with differences in acute lymphoblastic leukemia (ALL) survival. In the NOPHO ALL2008 trial, patients aged 1-45 years with BCR::ABL1-negative B-precursor and Tcell ALL were included, but neither sex nor age was integrated into risk group allocation. Among 1,771 trial patients stratified into protocol-appropriate risk groups, we estimated the impact of age and sex on survival (even after relapse) and toxicities prospectively registered at three-month intervals. In multivariate Cox regression analysis adjusted by sex, age group, and risk group, age but not sex was an independent risk factor for reduced 5-year event-free survival (EFS), hazard ratio 1.57 (95%CI 1.15-2.14) for patients 10-17.9 years, and 2.70 (2.03-3.58) for patients 18-45 years, compared to patients https://haematologica.org/article/view/11948 |
| spellingShingle | Tuomas Lahteenmaki Taalas Trausti Oskarsson Mats Heyman Bendik Lund Kristi Lepik Goda Vaitkevičiene Olafur Gisli Jonsson Julia Eriksson Nina Toft Laimonas Griškevičius Helene Hallbook Katrin Palk Ulla Wartiovaara-Kautto Petter Quist-Paulsen Ulrika Noren-Nystrom Kim Vettenranta Jonas Abrahamsson Kjeld Schmiegelow Paivi M Lahteenmaki Impact of age and sex on survival outcomes in patients aged 1-45 years with acute lymphoblastic leukemia treated according to the stratification used in the NOPHO ALL2008 trial Haematologica |
| title | Impact of age and sex on survival outcomes in patients aged 1-45 years with acute lymphoblastic leukemia treated according to the stratification used in the NOPHO ALL2008 trial |
| title_full | Impact of age and sex on survival outcomes in patients aged 1-45 years with acute lymphoblastic leukemia treated according to the stratification used in the NOPHO ALL2008 trial |
| title_fullStr | Impact of age and sex on survival outcomes in patients aged 1-45 years with acute lymphoblastic leukemia treated according to the stratification used in the NOPHO ALL2008 trial |
| title_full_unstemmed | Impact of age and sex on survival outcomes in patients aged 1-45 years with acute lymphoblastic leukemia treated according to the stratification used in the NOPHO ALL2008 trial |
| title_short | Impact of age and sex on survival outcomes in patients aged 1-45 years with acute lymphoblastic leukemia treated according to the stratification used in the NOPHO ALL2008 trial |
| title_sort | impact of age and sex on survival outcomes in patients aged 1 45 years with acute lymphoblastic leukemia treated according to the stratification used in the nopho all2008 trial |
| url | https://haematologica.org/article/view/11948 |
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