CYTOKINE MODULATION IN CARDIAC SURGERY: CASE SERIES
Аim. Extracorporeal circulation, temporary aortic cross-clamping, cardioplegic arrest, perioperative heart failure, and comorbidities all are among the leading risk factors of a systemic inflammatory response syndrome (SIRS), which in some cases progresses to multiple organ failure (MOF). It has bee...
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| Format: | Article |
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Kemerovo State Medical University
2018-12-01
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| Series: | Фундаментальная и клиническая медицина |
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| Online Access: | https://fcm.kemsmu.ru/jour/article/view/118 |
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| author | DMITRIY L. Shukevich ARTEM S. Radivilko EGOR S. Sardin ROMAN A. Kornelyuk MIKHAIL S. Rubtsov VERA G. Matveeva EVGENIY V. Grigoriev |
| author_facet | DMITRIY L. Shukevich ARTEM S. Radivilko EGOR S. Sardin ROMAN A. Kornelyuk MIKHAIL S. Rubtsov VERA G. Matveeva EVGENIY V. Grigoriev |
| author_sort | DMITRIY L. Shukevich |
| collection | DOAJ |
| description | Аim. Extracorporeal circulation, temporary aortic cross-clamping, cardioplegic arrest, perioperative heart failure, and comorbidities all are among the leading risk factors of a systemic inflammatory response syndrome (SIRS), which in some cases progresses to multiple organ failure (MOF). It has been recently suggested that sorption of inflammatory mediators using selective cytokine sorbents can prevent the development of MOF. We tested the efficacy of interleukin-6 (IL-6) sorption in pa-tients who underwent coronary artery bypass graft surgery requiring extracorporeal circulation with the subsequent development of sepsis (n = 9) and patients who was subjected to preventive adsorption during perfusion (n = 3). Materials and Methods. In addition to stan-dard clinical and biochemical parameters, we measured levels of serum IL-6 prior to the procedure, after the procedure and 24 hours after the sorption.Results. We noted a decrease in norepinephrine support and serum IL-6 as well as regression of MOF severity, particularly in patients with a preventive adsorption during the perfusion.Conclusions. IL-6 sorption is a promising method for correcting SIRS and MOF in patients who underwent coronary artery bypass graft sur-gery, particularly if applied in a preventive manner during the perfusion. |
| format | Article |
| id | doaj-art-a08db288269f429698e0610bc4e7f68c |
| institution | DOAJ |
| issn | 2500-0764 2542-0941 |
| language | Russian |
| publishDate | 2018-12-01 |
| publisher | Kemerovo State Medical University |
| record_format | Article |
| series | Фундаментальная и клиническая медицина |
| spelling | doaj-art-a08db288269f429698e0610bc4e7f68c2025-08-20T02:49:09ZrusKemerovo State Medical UniversityФундаментальная и клиническая медицина2500-07642542-09412018-12-01345159117CYTOKINE MODULATION IN CARDIAC SURGERY: CASE SERIESDMITRIY L. Shukevich0ARTEM S. Radivilko1EGOR S. Sardin2ROMAN A. Kornelyuk3MIKHAIL S. Rubtsov4VERA G. Matveeva5EVGENIY V. Grigoriev6Research Institute for Complex Issues of Cardiovascular Diseases; Kemerovo State Medical UniversityResearch Institute for Complex Issues of Cardiovascular DiseasesResearch Institute for Complex Issues of Cardiovascular DiseasesResearch Institute for Complex Issues of Cardiovascular Diseases; Kemerovo State Medical UniversityResearch Institute for Complex Issues of Cardiovascular DiseasesResearch Institute for Complex Issues of Cardiovascular DiseasesResearch Institute for Complex Issues of Cardiovascular Diseases; Kemerovo State Medical UniversityАim. Extracorporeal circulation, temporary aortic cross-clamping, cardioplegic arrest, perioperative heart failure, and comorbidities all are among the leading risk factors of a systemic inflammatory response syndrome (SIRS), which in some cases progresses to multiple organ failure (MOF). It has been recently suggested that sorption of inflammatory mediators using selective cytokine sorbents can prevent the development of MOF. We tested the efficacy of interleukin-6 (IL-6) sorption in pa-tients who underwent coronary artery bypass graft surgery requiring extracorporeal circulation with the subsequent development of sepsis (n = 9) and patients who was subjected to preventive adsorption during perfusion (n = 3). Materials and Methods. In addition to stan-dard clinical and biochemical parameters, we measured levels of serum IL-6 prior to the procedure, after the procedure and 24 hours after the sorption.Results. We noted a decrease in norepinephrine support and serum IL-6 as well as regression of MOF severity, particularly in patients with a preventive adsorption during the perfusion.Conclusions. IL-6 sorption is a promising method for correcting SIRS and MOF in patients who underwent coronary artery bypass graft sur-gery, particularly if applied in a preventive manner during the perfusion.https://fcm.kemsmu.ru/jour/article/view/118искусственное кровообращениекардиохирургиясорбция цитокиновсистемный воспалительный ответсепсисполиорганная недостаточностьextracorporeal circulationсardiac surgerycytokine adsorptionsystemic inflammatory responsesepsismultiorgan failure |
| spellingShingle | DMITRIY L. Shukevich ARTEM S. Radivilko EGOR S. Sardin ROMAN A. Kornelyuk MIKHAIL S. Rubtsov VERA G. Matveeva EVGENIY V. Grigoriev CYTOKINE MODULATION IN CARDIAC SURGERY: CASE SERIES Фундаментальная и клиническая медицина искусственное кровообращение кардиохирургия сорбция цитокинов системный воспалительный ответ сепсис полиорганная недостаточность extracorporeal circulation сardiac surgery cytokine adsorption systemic inflammatory response sepsis multiorgan failure |
| title | CYTOKINE MODULATION IN CARDIAC SURGERY: CASE SERIES |
| title_full | CYTOKINE MODULATION IN CARDIAC SURGERY: CASE SERIES |
| title_fullStr | CYTOKINE MODULATION IN CARDIAC SURGERY: CASE SERIES |
| title_full_unstemmed | CYTOKINE MODULATION IN CARDIAC SURGERY: CASE SERIES |
| title_short | CYTOKINE MODULATION IN CARDIAC SURGERY: CASE SERIES |
| title_sort | cytokine modulation in cardiac surgery case series |
| topic | искусственное кровообращение кардиохирургия сорбция цитокинов системный воспалительный ответ сепсис полиорганная недостаточность extracorporeal circulation сardiac surgery cytokine adsorption systemic inflammatory response sepsis multiorgan failure |
| url | https://fcm.kemsmu.ru/jour/article/view/118 |
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