Associations of blood RNA biomarkers and circulating tumour cells in patients with previously untreated metastatic colorectal cancer

Associations of blood RNA biomarkers and circulating tumour cells in patients with previously untreated metastatic colorectal cancer

Abstract Background In patients with metastatic colorectal cancer, analysis of the number of basal circulating tumour cells (bCTCs) has been shown to be a strong prognostic indicator. In this study, we aim to explore the potential associations between whole blood mRNA and microRNA expression profile...

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Main Authors: Manuel Valladares-Ayerbes, Marta Toledano-Fonseca, Begoña Graña, Paula Jimenez-Fonseca, Gema Pulido-Cortijo, Silvia Gil, Javier Sastre, Antonieta Salud, Fernando Rivera, Mercedes Salgado, Pilar García-Alfonso, Rafael López López, Carmen Guillén-Ponce, Antonio Rodríguez-Ariza, Jose Mª Vieitez, Eduardo Díaz-Rubio, Enrique Aranda, the Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Cancer
Subjects:
Circulating tumour cells
Liquid biopsy
Metastatic colorectal cancer
RNA biomarkers
Prognosis
Online Access:https://doi.org/10.1186/s12885-025-14098-9
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