A comprehensive review of glycocalyx investigation and therapeutic applications in sepsis and septic shock
Sepsis is a global health challenge that causes more than 11 million deaths annually and represents a substantial medical and economic burden. With rising treatment costs and significant mortality rates associated with organ dysfunction and septic shock, research efforts have focused on investigatin...
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| Format: | Article |
| Language: | English |
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Sciendo
2024-10-01
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| Series: | Romanian Journal of Laboratory Medicine |
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| Online Access: | https://doi.org/10.2478/rrlm-2024-0031 |
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| _version_ | 1850194541087293440 |
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| author | Muntean Anastasia Ambros Ala Cojocari Sergiu Maximciuc Ștefan Cumpătă Serghei |
| author_facet | Muntean Anastasia Ambros Ala Cojocari Sergiu Maximciuc Ștefan Cumpătă Serghei |
| author_sort | Muntean Anastasia |
| collection | DOAJ |
| description | Sepsis is a global health challenge that causes more than 11 million deaths annually and represents a substantial medical and economic burden. With rising treatment costs and significant mortality rates associated with organ dysfunction and septic shock, research efforts have focused on investigating the mechanism of glycocalyx (GCX) degradation as well as its regenerative capacity. Therefore, GCX has become a target in therapeutic strategies. |
| format | Article |
| id | doaj-art-a082497c33d0440683862bb026f6edc5 |
| institution | OA Journals |
| issn | 2284-5623 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Romanian Journal of Laboratory Medicine |
| spelling | doaj-art-a082497c33d0440683862bb026f6edc52025-08-20T02:13:58ZengSciendoRomanian Journal of Laboratory Medicine2284-56232024-10-0132432733610.2478/rrlm-2024-0031A comprehensive review of glycocalyx investigation and therapeutic applications in sepsis and septic shockMuntean Anastasia0Ambros Ala1Cojocari Sergiu2Maximciuc Ștefan3Cumpătă Serghei41Department of Biochemistry and Clinical biochemistry, Nicolae Testemițeanu State University of Medicine and Pharmacy, Chișinău, Moldova1Department of Biochemistry and Clinical biochemistry, Nicolae Testemițeanu State University of Medicine and Pharmacy, Chișinău, Moldova2Organic synthesis laboratory, Institute of Chemistry, Moldova State University, Chișinău, Moldova3STROKE unit, Diomid Gherman Institute of Neurology and Neurosurgery, Chișinău, Moldova4Department of Septic surgery, Gheorghe Paladi Municipal Clinical Hospital, Chișinău, MoldovaSepsis is a global health challenge that causes more than 11 million deaths annually and represents a substantial medical and economic burden. With rising treatment costs and significant mortality rates associated with organ dysfunction and septic shock, research efforts have focused on investigating the mechanism of glycocalyx (GCX) degradation as well as its regenerative capacity. Therefore, GCX has become a target in therapeutic strategies.https://doi.org/10.2478/rrlm-2024-0031endothelial cellglycocalyxinflammationsepsisseptic shock |
| spellingShingle | Muntean Anastasia Ambros Ala Cojocari Sergiu Maximciuc Ștefan Cumpătă Serghei A comprehensive review of glycocalyx investigation and therapeutic applications in sepsis and septic shock Romanian Journal of Laboratory Medicine endothelial cell glycocalyx inflammation sepsis septic shock |
| title | A comprehensive review of glycocalyx investigation and therapeutic applications in sepsis and septic shock |
| title_full | A comprehensive review of glycocalyx investigation and therapeutic applications in sepsis and septic shock |
| title_fullStr | A comprehensive review of glycocalyx investigation and therapeutic applications in sepsis and septic shock |
| title_full_unstemmed | A comprehensive review of glycocalyx investigation and therapeutic applications in sepsis and septic shock |
| title_short | A comprehensive review of glycocalyx investigation and therapeutic applications in sepsis and septic shock |
| title_sort | comprehensive review of glycocalyx investigation and therapeutic applications in sepsis and septic shock |
| topic | endothelial cell glycocalyx inflammation sepsis septic shock |
| url | https://doi.org/10.2478/rrlm-2024-0031 |
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