Bone status in young women with rheumatic diseases
Objective: to investigate bone mineral density (BMD) status and the factors influencing the latter in reproductive-aged women with rheumatic diseases (RDs).Subjects and methods. The investigation enrolled 134 women (mean age, 35 [29; 43] years): 94 patients with RDs (rheumatoid arthritis (RA), syste...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2019-12-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/2802 |
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| author | O. V. Dobrovolskaya N. V. Demin A. V. Smirnov L. A. Shornikova O. A. Nikitinskaya N. V. Toroptsova |
| author_facet | O. V. Dobrovolskaya N. V. Demin A. V. Smirnov L. A. Shornikova O. A. Nikitinskaya N. V. Toroptsova |
| author_sort | O. V. Dobrovolskaya |
| collection | DOAJ |
| description | Objective: to investigate bone mineral density (BMD) status and the factors influencing the latter in reproductive-aged women with rheumatic diseases (RDs).Subjects and methods. The investigation enrolled 134 women (mean age, 35 [29; 43] years): 94 patients with RDs (rheumatoid arthritis (RA), systemic sclerosis (SS), and psoriatic arthritis (PsA)) and 40 people without RDs. The investigators conducted a survey using a unified questionnaire, spine and proximal femur bone densitometry by dual energy X-ray absorptiometry (Hologic Discovery A Bone densitometer, USA), serum vitamin D measurement, and daily dietary calcium intake estimation.Results and discussion. Reduced BMD was detected significantly more often in the group of patients with RDs compared with the healthy control (25 and 8%, respectively; p=0.0213). It occurred in 48% of patients with RA, in 21% of those with SS, and in 15% of those with PsA. Patients with RDs showed a direct correlation of BMD in all areas of measurement with height, weight, body mass index, and serum vitamin D concentration and an inverse correlation with the cumulative dose of glucocorticoids. In addition, an inverse correlation was found between proximal femur BMD and RD duration. The patients with SS displayed an inverse relationship between BMD of both proximal femurs and C-reactive protein level; and the women with RA had exhibited this relationship between lumbar spine and femoral neck BMD and ESR.Conclusion. In general, 25% of reproductive-aged women with RDs need osteoporosis monitoring and prevention, and, in the presence of fractures, antiosteoporotic treatment. |
| format | Article |
| id | doaj-art-a07e4dd9e3c244c19e6dc9b9ed5c6993 |
| institution | DOAJ |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2019-12-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj-art-a07e4dd9e3c244c19e6dc9b9ed5c69932025-08-20T03:22:12ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922019-12-0157665766110.14412/1995-4484-2019-657-6612551Bone status in young women with rheumatic diseasesO. V. Dobrovolskaya0N. V. Demin1A. V. Smirnov2L. A. Shornikova3O. A. Nikitinskaya4N. V. Toroptsova5V.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyObjective: to investigate bone mineral density (BMD) status and the factors influencing the latter in reproductive-aged women with rheumatic diseases (RDs).Subjects and methods. The investigation enrolled 134 women (mean age, 35 [29; 43] years): 94 patients with RDs (rheumatoid arthritis (RA), systemic sclerosis (SS), and psoriatic arthritis (PsA)) and 40 people without RDs. The investigators conducted a survey using a unified questionnaire, spine and proximal femur bone densitometry by dual energy X-ray absorptiometry (Hologic Discovery A Bone densitometer, USA), serum vitamin D measurement, and daily dietary calcium intake estimation.Results and discussion. Reduced BMD was detected significantly more often in the group of patients with RDs compared with the healthy control (25 and 8%, respectively; p=0.0213). It occurred in 48% of patients with RA, in 21% of those with SS, and in 15% of those with PsA. Patients with RDs showed a direct correlation of BMD in all areas of measurement with height, weight, body mass index, and serum vitamin D concentration and an inverse correlation with the cumulative dose of glucocorticoids. In addition, an inverse correlation was found between proximal femur BMD and RD duration. The patients with SS displayed an inverse relationship between BMD of both proximal femurs and C-reactive protein level; and the women with RA had exhibited this relationship between lumbar spine and femoral neck BMD and ESR.Conclusion. In general, 25% of reproductive-aged women with RDs need osteoporosis monitoring and prevention, and, in the presence of fractures, antiosteoporotic treatment.https://rsp.mediar-press.net/rsp/article/view/2802reduced bone mineral densityglucocorticoidsvitamin drisk factorssystemic sclerosispsoriatic arthritisrheumatoid arthritis |
| spellingShingle | O. V. Dobrovolskaya N. V. Demin A. V. Smirnov L. A. Shornikova O. A. Nikitinskaya N. V. Toroptsova Bone status in young women with rheumatic diseases Научно-практическая ревматология reduced bone mineral density glucocorticoids vitamin d risk factors systemic sclerosis psoriatic arthritis rheumatoid arthritis |
| title | Bone status in young women with rheumatic diseases |
| title_full | Bone status in young women with rheumatic diseases |
| title_fullStr | Bone status in young women with rheumatic diseases |
| title_full_unstemmed | Bone status in young women with rheumatic diseases |
| title_short | Bone status in young women with rheumatic diseases |
| title_sort | bone status in young women with rheumatic diseases |
| topic | reduced bone mineral density glucocorticoids vitamin d risk factors systemic sclerosis psoriatic arthritis rheumatoid arthritis |
| url | https://rsp.mediar-press.net/rsp/article/view/2802 |
| work_keys_str_mv | AT ovdobrovolskaya bonestatusinyoungwomenwithrheumaticdiseases AT nvdemin bonestatusinyoungwomenwithrheumaticdiseases AT avsmirnov bonestatusinyoungwomenwithrheumaticdiseases AT lashornikova bonestatusinyoungwomenwithrheumaticdiseases AT oanikitinskaya bonestatusinyoungwomenwithrheumaticdiseases AT nvtoroptsova bonestatusinyoungwomenwithrheumaticdiseases |