Antidepressant therapy in complex treatment of painful diabetic polyneuropathy
Aims. Comparative efficiency and safety analysis of antidepressant agents from different pharmacological classes (pipofezine and venlafaxine)in combination with carbamazepine for treatment of neuropathic pain (NP) in patients with diabetic polyneuropathy (DP). Materials and methods. We examined 21...
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Endocrinology Research Centre
2012-09-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/6088 |
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| author | Lidia Grigor'evna Turbina Sergey Alexandrovich Gordeev Anna Aronovna Zus'man |
| author_facet | Lidia Grigor'evna Turbina Sergey Alexandrovich Gordeev Anna Aronovna Zus'man |
| author_sort | Lidia Grigor'evna Turbina |
| collection | DOAJ |
| description | Aims. Comparative efficiency and safety analysis of antidepressant agents from different pharmacological classes (pipofezine and venlafaxine)in combination with carbamazepine for treatment of neuropathic pain (NP) in patients with diabetic polyneuropathy (DP). Materials and methods. We examined 21 male and 27 female patients with painful DP (mean age 54.3?14.2 years; mean duration ofdiabetes mellitus (DM) 8.9?5.1 years; mean duration of DP - 3.8?2.1 years). DP was diagnosed clinically and by electromyographymethod. Pain syndrome was assessed with DN4 questionnaire, visual analogue scale (VAS) and McGill Pain Questionnaire. Psycho-vegetative status was evaluated by Spielberger test with reactive and personal anxiety (RA and PA) assessment and Beck depressioninventory. All patients received symptomatic pharmacotherapy with anticonvulsant and antidepressant agent. First group (DP-1)included 23 patients on carbamazepin and pipofezine. Second group (DP-2) included 25 patients on carbamazepin and venlafaxine. Results. Following treatment, pain syndrome was completely compensated in 8.7% of patients from DP-1 group and 12.5% from DP-2.Decrease in pain intensity?50% from initial level was achieved in 73.9% (DP-1) and 75% (DP-2) of cases. Mean pain intensityaccording to VAS reduced from 5.2?2.1 points to 2.3?1.4 points (DP-1) and from 5.8?2.3 points (DP-2) with equal statistical significance(p |
| format | Article |
| id | doaj-art-a07cf4cbcb9e484995ebefa677e678f8 |
| institution | OA Journals |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2012-09-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-a07cf4cbcb9e484995ebefa677e678f82025-08-20T02:29:34ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782012-09-01153677310.14341/2072-0351-60886046Antidepressant therapy in complex treatment of painful diabetic polyneuropathyLidia Grigor'evna Turbina0Sergey Alexandrovich Gordeev1Anna Aronovna Zus'man2Moscow Regional Clinical Research Institute named after Vladimirsky, Moscow, Russian FederationNeurology Research Centre, Moscow, Russian FederationMoscow Regional Clinical Research Institute named after Vladimirsky, Moscow; Moscow Tsar Clinic, MoscowAims. Comparative efficiency and safety analysis of antidepressant agents from different pharmacological classes (pipofezine and venlafaxine)in combination with carbamazepine for treatment of neuropathic pain (NP) in patients with diabetic polyneuropathy (DP). Materials and methods. We examined 21 male and 27 female patients with painful DP (mean age 54.3?14.2 years; mean duration ofdiabetes mellitus (DM) 8.9?5.1 years; mean duration of DP - 3.8?2.1 years). DP was diagnosed clinically and by electromyographymethod. Pain syndrome was assessed with DN4 questionnaire, visual analogue scale (VAS) and McGill Pain Questionnaire. Psycho-vegetative status was evaluated by Spielberger test with reactive and personal anxiety (RA and PA) assessment and Beck depressioninventory. All patients received symptomatic pharmacotherapy with anticonvulsant and antidepressant agent. First group (DP-1)included 23 patients on carbamazepin and pipofezine. Second group (DP-2) included 25 patients on carbamazepin and venlafaxine. Results. Following treatment, pain syndrome was completely compensated in 8.7% of patients from DP-1 group and 12.5% from DP-2.Decrease in pain intensity?50% from initial level was achieved in 73.9% (DP-1) and 75% (DP-2) of cases. Mean pain intensityaccording to VAS reduced from 5.2?2.1 points to 2.3?1.4 points (DP-1) and from 5.8?2.3 points (DP-2) with equal statistical significance(phttps://www.dia-endojournals.ru/jour/article/view/6088diabetic polyneuropathyneuropathic painanxietydepressionvenlafaxinepipofezinecarbamazepine |
| spellingShingle | Lidia Grigor'evna Turbina Sergey Alexandrovich Gordeev Anna Aronovna Zus'man Antidepressant therapy in complex treatment of painful diabetic polyneuropathy Сахарный диабет diabetic polyneuropathy neuropathic pain anxiety depression venlafaxine pipofezine carbamazepine |
| title | Antidepressant therapy in complex treatment of painful diabetic polyneuropathy |
| title_full | Antidepressant therapy in complex treatment of painful diabetic polyneuropathy |
| title_fullStr | Antidepressant therapy in complex treatment of painful diabetic polyneuropathy |
| title_full_unstemmed | Antidepressant therapy in complex treatment of painful diabetic polyneuropathy |
| title_short | Antidepressant therapy in complex treatment of painful diabetic polyneuropathy |
| title_sort | antidepressant therapy in complex treatment of painful diabetic polyneuropathy |
| topic | diabetic polyneuropathy neuropathic pain anxiety depression venlafaxine pipofezine carbamazepine |
| url | https://www.dia-endojournals.ru/jour/article/view/6088 |
| work_keys_str_mv | AT lidiagrigorevnaturbina antidepressanttherapyincomplextreatmentofpainfuldiabeticpolyneuropathy AT sergeyalexandrovichgordeev antidepressanttherapyincomplextreatmentofpainfuldiabeticpolyneuropathy AT annaaronovnazusman antidepressanttherapyincomplextreatmentofpainfuldiabeticpolyneuropathy |