Unresponsiveness induced by sevoflurane and propofol is associated with reduced basal forebrain cholinergic nuclei functional connectivity in humans, a pilot exploratory study

Unresponsiveness induced by sevoflurane and propofol is associated with reduced basal forebrain cholinergic nuclei functional connectivity in humans, a pilot exploratory study

Studies suggest the cholinergic system is involved in anesthesia-induced unconsciousness, hence unresponsiveness. A significant source of cholinergic innervation comes from basal forebrain cholinergic nuclei (BFCN), with bi-directional connections between anterior BFCN and the default mode network (...

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Bibliographic Details
Main Authors: Juliana Zimmermann, Rachel Nuttall, Daniel Golkowski, Gerhard Schneider, Andreas Ranft, Rüdiger Ilg, Afra Wohlschlaeger, Christian Sorg, Marlene Tahedl
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:NeuroImage: Reports
Subjects:
Anesthesia-induced unresponsiveness
Propofol
Sevoflurane
Basal forebrain cholinergic nuclei
Default mode network
Functional connectivity
Online Access:http://www.sciencedirect.com/science/article/pii/S2666956024000308
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