Evaluation of assumed tumour volume in multiple myeloma using dual-energy spectral CT and its correlation between haematological findings
Objectives: To measure the assumed tumour volume in the humerus of patients with multiple myeloma using dual-energy spectral computed tomography (DESCT) and to evaluate the correlation with haematological indicators. Methods: We retrospectively analysed 82 DESCT examinations of 22 patients diagnosed...
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Elsevier
2025-12-01
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| Series: | European Journal of Radiology Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352047725000425 |
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| author | Tetsuya Kosaka Chisaki Masuda Sachiho Tatebe Risen Hirai Akira Tanimura |
| author_facet | Tetsuya Kosaka Chisaki Masuda Sachiho Tatebe Risen Hirai Akira Tanimura |
| author_sort | Tetsuya Kosaka |
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| description | Objectives: To measure the assumed tumour volume in the humerus of patients with multiple myeloma using dual-energy spectral computed tomography (DESCT) and to evaluate the correlation with haematological indicators. Methods: We retrospectively analysed 82 DESCT examinations of 22 patients diagnosed with multiple myeloma. After extracting the bilateral humeri and removing the bone tissue, we measured the volume of the assumed tumour area using a single threshold based on Hounsfield unit values and double thresholds using material density images. We analysed the correlations between tumour volume and haematological indicators (β2-microglobulin, M-protein, free light chain, albumin, lactate dehydrogenase) and the trends after treatment intervention. Results: A moderate correlation was identified between the assumed tumour volume in the initial scan and the β2-microglobulin level, with a correlation coefficient of ρ = 0.69 for the volume calculated from a single threshold value of Hounsfield unit and ρ = 0.57 for the volume calculated from a double threshold value of the bone(fat) material density image. No significant correlation was found between the assumed tumour volume and the M-protein or free light chain levels. In patients who underwent three or more follow-up evaluations after the initial examination, there was a similarity in the changes in the assumed tumour volume and β2-microglobulin levels after treatment. Conclusion: Extracting assumed tumour volume using DESCT has sufficient potential as a biomarker for multiple myeloma. |
| format | Article |
| id | doaj-art-a072abe1e8694e37ba15d2c26e0367b6 |
| institution | Kabale University |
| issn | 2352-0477 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Elsevier |
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| series | European Journal of Radiology Open |
| spelling | doaj-art-a072abe1e8694e37ba15d2c26e0367b62025-08-20T03:31:37ZengElsevierEuropean Journal of Radiology Open2352-04772025-12-011510067510.1016/j.ejro.2025.100675Evaluation of assumed tumour volume in multiple myeloma using dual-energy spectral CT and its correlation between haematological findingsTetsuya Kosaka0Chisaki Masuda1Sachiho Tatebe2Risen Hirai3Akira Tanimura4Department of Diagnostic Radiology, Tokyo-Kita Medical Center, 4-17-56 Akabanedai, Kita-ku, Tokyo, Japan; Correspondence to: Department of Diagnostic Radiology, Tokyo-Kita Medical Centre, 4-17-56 Akabanedai, Kita-ku, Tokyo 115-0053, Japan.Department of Diagnostic Radiology, Tokyo-Kita Medical Center, 4-17-56 Akabanedai, Kita-ku, Tokyo, Japan; Department of Diagnostic Radiology, Kitasato University School of Medicine, 1-15-1 kitazato, Minami-ku, Sagamihara-shi, Kanagawa, JapanDepartment of Diagnostic Radiology, Tokyo-Kita Medical Center, 4-17-56 Akabanedai, Kita-ku, Tokyo, JapanDepartment of Haematology, Tokyo-Kita Medical Centre,4-17-56 Akabanedai, Kita-ku, Tokyo, JapanDepartment of Haematology, Tokyo-Kita Medical Centre,4-17-56 Akabanedai, Kita-ku, Tokyo, JapanObjectives: To measure the assumed tumour volume in the humerus of patients with multiple myeloma using dual-energy spectral computed tomography (DESCT) and to evaluate the correlation with haematological indicators. Methods: We retrospectively analysed 82 DESCT examinations of 22 patients diagnosed with multiple myeloma. After extracting the bilateral humeri and removing the bone tissue, we measured the volume of the assumed tumour area using a single threshold based on Hounsfield unit values and double thresholds using material density images. We analysed the correlations between tumour volume and haematological indicators (β2-microglobulin, M-protein, free light chain, albumin, lactate dehydrogenase) and the trends after treatment intervention. Results: A moderate correlation was identified between the assumed tumour volume in the initial scan and the β2-microglobulin level, with a correlation coefficient of ρ = 0.69 for the volume calculated from a single threshold value of Hounsfield unit and ρ = 0.57 for the volume calculated from a double threshold value of the bone(fat) material density image. No significant correlation was found between the assumed tumour volume and the M-protein or free light chain levels. In patients who underwent three or more follow-up evaluations after the initial examination, there was a similarity in the changes in the assumed tumour volume and β2-microglobulin levels after treatment. Conclusion: Extracting assumed tumour volume using DESCT has sufficient potential as a biomarker for multiple myeloma.http://www.sciencedirect.com/science/article/pii/S2352047725000425Multiple myelomaDual-energy spectral CTTumour volumeβ2-microglobulin |
| spellingShingle | Tetsuya Kosaka Chisaki Masuda Sachiho Tatebe Risen Hirai Akira Tanimura Evaluation of assumed tumour volume in multiple myeloma using dual-energy spectral CT and its correlation between haematological findings European Journal of Radiology Open Multiple myeloma Dual-energy spectral CT Tumour volume β2-microglobulin |
| title | Evaluation of assumed tumour volume in multiple myeloma using dual-energy spectral CT and its correlation between haematological findings |
| title_full | Evaluation of assumed tumour volume in multiple myeloma using dual-energy spectral CT and its correlation between haematological findings |
| title_fullStr | Evaluation of assumed tumour volume in multiple myeloma using dual-energy spectral CT and its correlation between haematological findings |
| title_full_unstemmed | Evaluation of assumed tumour volume in multiple myeloma using dual-energy spectral CT and its correlation between haematological findings |
| title_short | Evaluation of assumed tumour volume in multiple myeloma using dual-energy spectral CT and its correlation between haematological findings |
| title_sort | evaluation of assumed tumour volume in multiple myeloma using dual energy spectral ct and its correlation between haematological findings |
| topic | Multiple myeloma Dual-energy spectral CT Tumour volume β2-microglobulin |
| url | http://www.sciencedirect.com/science/article/pii/S2352047725000425 |
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