Comparison of neutralizing antibody responses elicited from highly diverse polyvalent heterotrimeric HIV-1 gp140 cocktail immunogens versus a monovalent counterpart in rhesus macaques.

Comparison of neutralizing antibody responses elicited from highly diverse polyvalent heterotrimeric HIV-1 gp140 cocktail immunogens versus a monovalent counterpart in rhesus macaques.

Eliciting neutralizing antibodies capable of inactivating a broad spectrum of HIV-1 strains is a major goal of HIV-1 vaccine design. The challenge is that envelopes (Envs) of circulating viruses are almost certainly different from any Env used in a vaccine. A novel immunogen composed of a highly div...

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Main Authors: Emma J Bowles, Torben Schiffner, Maximillian Rosario, Gemma A Needham, Meghna Ramaswamy, Joanna McGouran, Benedikt Kessler, Celia LaBranche, Andrew J McMichael, David Montefiori, Quentin J Sattentau, Tomáš Hanke, Guillaume B E Stewart-Jones
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0114709
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