A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death

A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death

Abstract In sepsis, limited food intake and increased energy expenditure induce a starvation response, which is compromised by a quick decline in the expression of hepatic PPARα, a transcription factor essential in intracellular catabolism of free fatty acids. The mechanism upstream of this PPARα do...

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Main Authors: Céline Van Dender, Steven Timmermans, Ville Paakinaho, Tineke Vanderhaeghen, Jolien Vandewalle, Maarten Claes, Bruno Garcia, Bart Roman, Jan De Waele, Siska Croubels, Karolien De Bosscher, Philip Meuleman, Antoine Herpain, Jorma J Palvimo, Claude Libert
Format: Article
Language:English
Published: Springer Nature 2024-09-01
Series:EMBO Molecular Medicine
Subjects:
Acute Phase Response Failure
HNF4α Dysfunction
Liver
PPARα-mediated Lipid Dysfunction
Sepsis
Online Access:https://doi.org/10.1038/s44321-024-00130-1
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