Nuclear Lactate Dehydrogenase A Resists Cardiomyocyte Cell Cycle Arrest Induced by Oxidative Stress

Nuclear Lactate Dehydrogenase A Resists Cardiomyocyte Cell Cycle Arrest Induced by Oxidative Stress

A sudden increase in ambient oxygen concentration after birth forces the metabolic switch from anaerobic glycolysis to oxidative phosphorylation, which contributes to the rapid decline of cardiomyocyte proliferation. Lactate dehydrogenase A (LDHA), a metabolic enzyme normally localized in the cytopl...

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Bibliographic Details
Main Authors: Mengfei Cao, Jie Luo, Kewei Fu, Yao Xu, Yinyu Wang, Junying Duan, Rui Chen, Wei Yuan
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Journal of Cardiovascular Development and Disease
Subjects:
nuclear lactate dehydrogenase A
cardiomyocyte proliferation
oxidative stress
hypoxia
Online Access:https://www.mdpi.com/2308-3425/12/7/278
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