Research Progress on the Preparation and Application of Decellularized Tendons
Tendons connect animal skeletons to skeletal muscles, playing a crucial role in weight-bearing and maintaining motor functions. After decellularization, tendon extracellular matrix (tECM) retains the physicochemical characteristics similar to those of native tendons. This has made tECM a promising b...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
|
| Series: | Current Issues in Molecular Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1467-3045/47/4/251 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850183447549575168 |
|---|---|
| author | Jing Li Mingxing Wen Sujuan Zhang Lingfei Du Xin Fan Hao Liang Hong Wang Jing Sun Yuchun Ding Liangpeng Ge Jideng Ma Jinwei Zhang |
| author_facet | Jing Li Mingxing Wen Sujuan Zhang Lingfei Du Xin Fan Hao Liang Hong Wang Jing Sun Yuchun Ding Liangpeng Ge Jideng Ma Jinwei Zhang |
| author_sort | Jing Li |
| collection | DOAJ |
| description | Tendons connect animal skeletons to skeletal muscles, playing a crucial role in weight-bearing and maintaining motor functions. After decellularization, tendon extracellular matrix (tECM) retains the physicochemical characteristics similar to those of native tendons. This has made tECM a promising biomaterial in the fields of tissue engineering and regenerative medicine in recent years. This paper summarizes the origin, structure, and ECM components of animal tendons, reviews decellularization methods, and discusses recent advancements in the research and applications of decellularized tendons. Furthermore, it explores future development trends of xenogeneic decellularized tendon materials, aiming to provide a reference for fundamental research and the development of biomaterials related to decellularized tendons. |
| format | Article |
| id | doaj-art-a05b39b00dab4d3aafd0c7c2fe63798e |
| institution | OA Journals |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj-art-a05b39b00dab4d3aafd0c7c2fe63798e2025-08-20T02:17:20ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452025-04-0147425110.3390/cimb47040251Research Progress on the Preparation and Application of Decellularized TendonsJing Li0Mingxing Wen1Sujuan Zhang2Lingfei Du3Xin Fan4Hao Liang5Hong Wang6Jing Sun7Yuchun Ding8Liangpeng Ge9Jideng Ma10Jinwei Zhang11Chongqing Academy of Animal Sciences, Chongqing 402460, ChinaSichuan Provincial Key Laboratory of Exploration and Innovative Utilization of Livestock and Poultry Genetic Resources, Sichuan Agricultural University, Chengdu 611130, ChinaNational Center of Technology Innovation for Pigs, Chongqing 402460, ChinaNational Center of Technology Innovation for Pigs, Chongqing 402460, ChinaChongqing Academy of Animal Sciences, Chongqing 402460, ChinaChongqing Academy of Animal Sciences, Chongqing 402460, ChinaChongqing Academy of Animal Sciences, Chongqing 402460, ChinaChongqing Academy of Animal Sciences, Chongqing 402460, ChinaChongqing Academy of Animal Sciences, Chongqing 402460, ChinaChongqing Academy of Animal Sciences, Chongqing 402460, ChinaSichuan Provincial Key Laboratory of Exploration and Innovative Utilization of Livestock and Poultry Genetic Resources, Sichuan Agricultural University, Chengdu 611130, ChinaChongqing Academy of Animal Sciences, Chongqing 402460, ChinaTendons connect animal skeletons to skeletal muscles, playing a crucial role in weight-bearing and maintaining motor functions. After decellularization, tendon extracellular matrix (tECM) retains the physicochemical characteristics similar to those of native tendons. This has made tECM a promising biomaterial in the fields of tissue engineering and regenerative medicine in recent years. This paper summarizes the origin, structure, and ECM components of animal tendons, reviews decellularization methods, and discusses recent advancements in the research and applications of decellularized tendons. Furthermore, it explores future development trends of xenogeneic decellularized tendon materials, aiming to provide a reference for fundamental research and the development of biomaterials related to decellularized tendons.https://www.mdpi.com/1467-3045/47/4/251tendonsdecellularizationstructural componentsapplications |
| spellingShingle | Jing Li Mingxing Wen Sujuan Zhang Lingfei Du Xin Fan Hao Liang Hong Wang Jing Sun Yuchun Ding Liangpeng Ge Jideng Ma Jinwei Zhang Research Progress on the Preparation and Application of Decellularized Tendons Current Issues in Molecular Biology tendons decellularization structural components applications |
| title | Research Progress on the Preparation and Application of Decellularized Tendons |
| title_full | Research Progress on the Preparation and Application of Decellularized Tendons |
| title_fullStr | Research Progress on the Preparation and Application of Decellularized Tendons |
| title_full_unstemmed | Research Progress on the Preparation and Application of Decellularized Tendons |
| title_short | Research Progress on the Preparation and Application of Decellularized Tendons |
| title_sort | research progress on the preparation and application of decellularized tendons |
| topic | tendons decellularization structural components applications |
| url | https://www.mdpi.com/1467-3045/47/4/251 |
| work_keys_str_mv | AT jingli researchprogressonthepreparationandapplicationofdecellularizedtendons AT mingxingwen researchprogressonthepreparationandapplicationofdecellularizedtendons AT sujuanzhang researchprogressonthepreparationandapplicationofdecellularizedtendons AT lingfeidu researchprogressonthepreparationandapplicationofdecellularizedtendons AT xinfan researchprogressonthepreparationandapplicationofdecellularizedtendons AT haoliang researchprogressonthepreparationandapplicationofdecellularizedtendons AT hongwang researchprogressonthepreparationandapplicationofdecellularizedtendons AT jingsun researchprogressonthepreparationandapplicationofdecellularizedtendons AT yuchunding researchprogressonthepreparationandapplicationofdecellularizedtendons AT liangpengge researchprogressonthepreparationandapplicationofdecellularizedtendons AT jidengma researchprogressonthepreparationandapplicationofdecellularizedtendons AT jinweizhang researchprogressonthepreparationandapplicationofdecellularizedtendons |