Decoding epithelial–fibroblast interactions in lung adenocarcinoma through single-cell and spatial transcriptomics

Decoding epithelial–fibroblast interactions in lung adenocarcinoma through single-cell and spatial transcriptomics

Abstract Background Lung adenocarcinoma (LUAD) exhibits significant cellular heterogeneity, yet the precise interactions between epithelial and stromal cells remain unclear. This study integrates single-cell and spatial transcriptomics to delineate tumor microenvironment dynamics, aiming to uncover...

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Bibliographic Details
Main Authors: Jiajin Yang, Qiuping Xu, Yanjun Lu
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Journal of Cancer Research and Clinical Oncology
Subjects:
Lung adenocarcinoma
Single-cell transcriptomics
Tumor microenvironment
Epithelial cell
Fibroblast
Online Access:https://doi.org/10.1007/s00432-025-06250-6
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