Comparison the Efficacy of Fluconazole and Terbinafine in Patients with Moderate to Severe Seborrheic Dermatitis
Background. Topical agents can be unpleasant due to long-term therapies in patients with moderate to severe seborrheic dermatitis. Systemic antifungal therapy is another alternative in treatment. Aim. This study was conducted to compare the efficacy of oral fluconazole and terbinafine in the treatme...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2014/705402 |
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| author | Narges Alizadeh Hamed Monadi Nori Javad Golchi Shahriar S. Eshkevari Ehsan Kazemnejad Abbas Darjani |
| author_facet | Narges Alizadeh Hamed Monadi Nori Javad Golchi Shahriar S. Eshkevari Ehsan Kazemnejad Abbas Darjani |
| author_sort | Narges Alizadeh |
| collection | DOAJ |
| description | Background. Topical agents can be unpleasant due to long-term therapies in patients with moderate to severe seborrheic dermatitis. Systemic antifungal therapy is another alternative in treatment. Aim. This study was conducted to compare the efficacy of oral fluconazole and terbinafine in the treatment of moderate to severe seborrheic dermatitis. Methods. 64 patients with moderate to severe seborrheic dermatitis (SD) were enrolled in a randomized, parallel-group study. One study group took terbinafine 250 mg daily (n=32) and the other one fluconazole 300 mg (n=32) weekly for four weeks. Seborrheic dermatitis area severity index (SDASI) and the intensity of itching were calculated before, at the end of treatment, and two weeks after treatment. Results. Both drugs significantly reduced the severity of seborrheic dermatitis (P<0.001). Multivariate linear regression revealed that efficacy of terbinafine is more than fluconazole (P<0.01, 95% CI (0.63–4.7)). Moreover, each index of SD severity reduced 0.9 times after treatment. (P<0.002, 95% CI (0.8–1.02)). The itching rate significantly diminished (P<0.001); however, there was no difference between these two drugs statistically. Conclusions. Both systemic antifungal therapies may reduce the severity index of SD. However, terbinafine showed more reduction in the intensity of the disease. In other words, the more the primary intensity of the disease is, the more its reduction will be. This trial is resgistered with 201102205871N1. |
| format | Article |
| id | doaj-art-a0534f18a910458a9689d973225c8d74 |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-a0534f18a910458a9689d973225c8d742025-02-03T01:09:13ZengWileyDermatology Research and Practice1687-61051687-61132014-01-01201410.1155/2014/705402705402Comparison the Efficacy of Fluconazole and Terbinafine in Patients with Moderate to Severe Seborrheic DermatitisNarges Alizadeh0Hamed Monadi Nori1Javad Golchi2Shahriar S. Eshkevari3Ehsan Kazemnejad4Abbas Darjani5Department of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht 41448, IranDepartment of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht 41448, IranDepartment of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht 41448, IranDepartment of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht 41448, IranDepartment of Preventive and Community Medicine, Guilan University of Medical Sciences, Rasht, IranDepartment of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht 41448, IranBackground. Topical agents can be unpleasant due to long-term therapies in patients with moderate to severe seborrheic dermatitis. Systemic antifungal therapy is another alternative in treatment. Aim. This study was conducted to compare the efficacy of oral fluconazole and terbinafine in the treatment of moderate to severe seborrheic dermatitis. Methods. 64 patients with moderate to severe seborrheic dermatitis (SD) were enrolled in a randomized, parallel-group study. One study group took terbinafine 250 mg daily (n=32) and the other one fluconazole 300 mg (n=32) weekly for four weeks. Seborrheic dermatitis area severity index (SDASI) and the intensity of itching were calculated before, at the end of treatment, and two weeks after treatment. Results. Both drugs significantly reduced the severity of seborrheic dermatitis (P<0.001). Multivariate linear regression revealed that efficacy of terbinafine is more than fluconazole (P<0.01, 95% CI (0.63–4.7)). Moreover, each index of SD severity reduced 0.9 times after treatment. (P<0.002, 95% CI (0.8–1.02)). The itching rate significantly diminished (P<0.001); however, there was no difference between these two drugs statistically. Conclusions. Both systemic antifungal therapies may reduce the severity index of SD. However, terbinafine showed more reduction in the intensity of the disease. In other words, the more the primary intensity of the disease is, the more its reduction will be. This trial is resgistered with 201102205871N1.http://dx.doi.org/10.1155/2014/705402 |
| spellingShingle | Narges Alizadeh Hamed Monadi Nori Javad Golchi Shahriar S. Eshkevari Ehsan Kazemnejad Abbas Darjani Comparison the Efficacy of Fluconazole and Terbinafine in Patients with Moderate to Severe Seborrheic Dermatitis Dermatology Research and Practice |
| title | Comparison the Efficacy of Fluconazole and Terbinafine in Patients with Moderate to Severe Seborrheic Dermatitis |
| title_full | Comparison the Efficacy of Fluconazole and Terbinafine in Patients with Moderate to Severe Seborrheic Dermatitis |
| title_fullStr | Comparison the Efficacy of Fluconazole and Terbinafine in Patients with Moderate to Severe Seborrheic Dermatitis |
| title_full_unstemmed | Comparison the Efficacy of Fluconazole and Terbinafine in Patients with Moderate to Severe Seborrheic Dermatitis |
| title_short | Comparison the Efficacy of Fluconazole and Terbinafine in Patients with Moderate to Severe Seborrheic Dermatitis |
| title_sort | comparison the efficacy of fluconazole and terbinafine in patients with moderate to severe seborrheic dermatitis |
| url | http://dx.doi.org/10.1155/2014/705402 |
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