Inhibitory effect of luteolin on the metabolism of vandetanib in vivo and in vitro

Inhibitory effect of luteolin on the metabolism of vandetanib in vivo and in vitro

This study aimed to examine the potential drug-drug interaction (DDI) between vandetanib and luteolin in vivo and in vitro, with the objective of establishing a scientific foundation for their appropriate utilization in clinical settings. Sprague-Dawley (SD) rats were randomly divided into two group...

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Bibliographic Details
Main Authors: Yuxin Shen, Fengsheng Hong, Hualu Wu, Xiaohai Chen, Hailun Xia, Ren-ai Xu, Guanyang Lin, Lu Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
vandetanib
luteolin
drug-drug interaction
UPLC-MS/MS
molecular docking
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1526159/full
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