Effect of concomitant diseases on the hemostasis system in the perioperative period of non-cardiac surgery
This study examined the effect of clinical factors and antithrombotic therapy on the blood coagulation system of patients in the perioperative period. The study included 80 patients who underwent elective noncardiac surgery. Laboratory control of hemostasis was carried out using routine tests for st...
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| Format: | Article |
| Language: | Russian |
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Open Systems Publication
2021-12-01
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| Series: | Лечащий Врач |
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| Online Access: | https://journal.lvrach.ru/jour/article/view/842 |
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| author | I. S. Pryakhin S. S. Murashko S. A. Berns I. N. Pasechnik |
| author_facet | I. S. Pryakhin S. S. Murashko S. A. Berns I. N. Pasechnik |
| author_sort | I. S. Pryakhin |
| collection | DOAJ |
| description | This study examined the effect of clinical factors and antithrombotic therapy on the blood coagulation system of patients in the perioperative period. The study included 80 patients who underwent elective noncardiac surgery. Laboratory control of hemostasis was carried out using routine tests for studying hemostasis (APTT, INR) and a global test for hemostasis (thrombodynamics test). Usage of the thrombodynamics test in this study was more sensitive compared to routine tests and made it possible to identify clinical factors associated with hypercoagulable states and «decreasing in the effectiveness» of low molecular weight heparins in the postoperative period. These factors are: age over 60 years, chronic ischemic heart disease, a history of coronary artery stenting, prior antithrombotic therapy before surgery. Hypercoagulability was found on the first day after surgery in patients with deep vein thrombosis of the lower extremities compared to other patients. The use of a thrombodynamics test a day before surgery allowed to predict an increase of intraoperative blood loss volume. Perioperative bridge therapy with low molecular weight heparins in high thrombotic risk patients was significantly associated with an increase in packed red blood cells transfusion of almost two times compared with other patients and is associated with an increased risk of hemorrhagic complications. The results of the study showed that thrombodynamics test can potentially be used further with the aim of personalizing patients’ management in the non-cardiac surgery perioperative period. It also helps to predict the occurrence of hemorrhagic and thrombotic complications. |
| format | Article |
| id | doaj-art-a04cd8fede3e4521af757169bcf34bed |
| institution | DOAJ |
| issn | 1560-5175 2687-1181 |
| language | Russian |
| publishDate | 2021-12-01 |
| publisher | Open Systems Publication |
| record_format | Article |
| series | Лечащий Врач |
| spelling | doaj-art-a04cd8fede3e4521af757169bcf34bed2025-08-20T02:49:01ZrusOpen Systems PublicationЛечащий Врач1560-51752687-11812021-12-01111737810.51793/OS.2021.24.11.012840Effect of concomitant diseases on the hemostasis system in the perioperative period of non-cardiac surgeryI. S. Pryakhin0S. S. Murashko1S. A. Berns2I. N. Pasechnik3Central State Medical Academy of the Administrative Department of the President of the Russian Federation; Joint Hospital with Polyclinic of the Administrative Department of the President of the Russian FederationCentral State Medical Academy of the Administrative Department of the President of the Russian Federation; Joint Hospital with Polyclinic of the Administrative Department of the President of the Russian FederationFederal State Institution National Medical Research Center for therapy and Preventive Medicine of the Ministry of Healthcare of the Russian FederationCentral State Medical Academy of the Administrative Department of the President of the Russian FederationThis study examined the effect of clinical factors and antithrombotic therapy on the blood coagulation system of patients in the perioperative period. The study included 80 patients who underwent elective noncardiac surgery. Laboratory control of hemostasis was carried out using routine tests for studying hemostasis (APTT, INR) and a global test for hemostasis (thrombodynamics test). Usage of the thrombodynamics test in this study was more sensitive compared to routine tests and made it possible to identify clinical factors associated with hypercoagulable states and «decreasing in the effectiveness» of low molecular weight heparins in the postoperative period. These factors are: age over 60 years, chronic ischemic heart disease, a history of coronary artery stenting, prior antithrombotic therapy before surgery. Hypercoagulability was found on the first day after surgery in patients with deep vein thrombosis of the lower extremities compared to other patients. The use of a thrombodynamics test a day before surgery allowed to predict an increase of intraoperative blood loss volume. Perioperative bridge therapy with low molecular weight heparins in high thrombotic risk patients was significantly associated with an increase in packed red blood cells transfusion of almost two times compared with other patients and is associated with an increased risk of hemorrhagic complications. The results of the study showed that thrombodynamics test can potentially be used further with the aim of personalizing patients’ management in the non-cardiac surgery perioperative period. It also helps to predict the occurrence of hemorrhagic and thrombotic complications.https://journal.lvrach.ru/jour/article/view/842non-cardiac surgerycoronary heart diseaseanticoagulantsthrombodynamic |
| spellingShingle | I. S. Pryakhin S. S. Murashko S. A. Berns I. N. Pasechnik Effect of concomitant diseases on the hemostasis system in the perioperative period of non-cardiac surgery Лечащий Врач non-cardiac surgery coronary heart disease anticoagulants thrombodynamic |
| title | Effect of concomitant diseases on the hemostasis system in the perioperative period of non-cardiac surgery |
| title_full | Effect of concomitant diseases on the hemostasis system in the perioperative period of non-cardiac surgery |
| title_fullStr | Effect of concomitant diseases on the hemostasis system in the perioperative period of non-cardiac surgery |
| title_full_unstemmed | Effect of concomitant diseases on the hemostasis system in the perioperative period of non-cardiac surgery |
| title_short | Effect of concomitant diseases on the hemostasis system in the perioperative period of non-cardiac surgery |
| title_sort | effect of concomitant diseases on the hemostasis system in the perioperative period of non cardiac surgery |
| topic | non-cardiac surgery coronary heart disease anticoagulants thrombodynamic |
| url | https://journal.lvrach.ru/jour/article/view/842 |
| work_keys_str_mv | AT ispryakhin effectofconcomitantdiseasesonthehemostasissystemintheperioperativeperiodofnoncardiacsurgery AT ssmurashko effectofconcomitantdiseasesonthehemostasissystemintheperioperativeperiodofnoncardiacsurgery AT saberns effectofconcomitantdiseasesonthehemostasissystemintheperioperativeperiodofnoncardiacsurgery AT inpasechnik effectofconcomitantdiseasesonthehemostasissystemintheperioperativeperiodofnoncardiacsurgery |