Targeted nanomedicines for the treatment of Helicobacter pylori infection
Helicobacter pylori is a significant risk factor for gastric cancer, making its elimination crucial for prevention. This review explores the application of nanotechnology in enhancing treatment efficacy against H. pylori and addressing antibiotic resistance. Nanomaterials are utilized as drug carrie...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425003801 |
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| author | Shi Wang Hao Ding Longsong Li Ruifang Zhao Ningli Chai |
| author_facet | Shi Wang Hao Ding Longsong Li Ruifang Zhao Ningli Chai |
| author_sort | Shi Wang |
| collection | DOAJ |
| description | Helicobacter pylori is a significant risk factor for gastric cancer, making its elimination crucial for prevention. This review explores the application of nanotechnology in enhancing treatment efficacy against H. pylori and addressing antibiotic resistance. Nanomaterials are utilized as drug carriers to protect pharmaceuticals from the acidic gastric environment and enable controlled release. These materials can be specifically engineered to target H. pylori surface molecules, thereby improving antimicrobial efficacy. Enhanced drug penetration is achieved by optimizing the surface properties and molecular architecture of nanomaterials. Additional strategies include targeting H. pylori virulence factors, such as urease and vacuolating cytotoxin A, as well as inhibiting bacterial proliferation through reactive oxygen species-based therapies. Moreover, the ability of nanomaterials to effectively modulate the microbiota and inhibit pathogens has shown great potential in the application of combating H. pylori. By focusing on specific invasion mechanisms and metabolic pathways, nanotechnology offers significant promise for advancing treatments against H. pylori. Despite its potential, several challenges remain, including high drug development costs, difficulties in precise targeting, and adverse effects associated with certain approaches, such as photothermal therapy. Ongoing optimization of nanotechnological strategies is anticipated to address these challenges, thereby facilitating the development of more effective and targeted therapies for H. pylori infection. |
| format | Article |
| id | doaj-art-a04af96ebfbc4805913bfb65fbced3f3 |
| institution | OA Journals |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-a04af96ebfbc4805913bfb65fbced3f32025-08-20T02:13:59ZengElsevierMaterials Today Bio2590-00642025-06-013210182010.1016/j.mtbio.2025.101820Targeted nanomedicines for the treatment of Helicobacter pylori infectionShi Wang0Hao Ding1Longsong Li2Ruifang Zhao3Ningli Chai4Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China; Graduate School of the People's Liberation Army (PLA) General Hospital, Beijing, 100853, PR China; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, PR ChinaCAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, PR ChinaDepartment of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China; Corresponding author.CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, PR China; Corresponding author.Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China; Corresponding author.Helicobacter pylori is a significant risk factor for gastric cancer, making its elimination crucial for prevention. This review explores the application of nanotechnology in enhancing treatment efficacy against H. pylori and addressing antibiotic resistance. Nanomaterials are utilized as drug carriers to protect pharmaceuticals from the acidic gastric environment and enable controlled release. These materials can be specifically engineered to target H. pylori surface molecules, thereby improving antimicrobial efficacy. Enhanced drug penetration is achieved by optimizing the surface properties and molecular architecture of nanomaterials. Additional strategies include targeting H. pylori virulence factors, such as urease and vacuolating cytotoxin A, as well as inhibiting bacterial proliferation through reactive oxygen species-based therapies. Moreover, the ability of nanomaterials to effectively modulate the microbiota and inhibit pathogens has shown great potential in the application of combating H. pylori. By focusing on specific invasion mechanisms and metabolic pathways, nanotechnology offers significant promise for advancing treatments against H. pylori. Despite its potential, several challenges remain, including high drug development costs, difficulties in precise targeting, and adverse effects associated with certain approaches, such as photothermal therapy. Ongoing optimization of nanotechnological strategies is anticipated to address these challenges, thereby facilitating the development of more effective and targeted therapies for H. pylori infection.http://www.sciencedirect.com/science/article/pii/S2590006425003801Helicobacter pyloriNanomedicineAntibacterial nanomaterialsDrug deliveryAntibiotic resistance |
| spellingShingle | Shi Wang Hao Ding Longsong Li Ruifang Zhao Ningli Chai Targeted nanomedicines for the treatment of Helicobacter pylori infection Materials Today Bio Helicobacter pylori Nanomedicine Antibacterial nanomaterials Drug delivery Antibiotic resistance |
| title | Targeted nanomedicines for the treatment of Helicobacter pylori infection |
| title_full | Targeted nanomedicines for the treatment of Helicobacter pylori infection |
| title_fullStr | Targeted nanomedicines for the treatment of Helicobacter pylori infection |
| title_full_unstemmed | Targeted nanomedicines for the treatment of Helicobacter pylori infection |
| title_short | Targeted nanomedicines for the treatment of Helicobacter pylori infection |
| title_sort | targeted nanomedicines for the treatment of helicobacter pylori infection |
| topic | Helicobacter pylori Nanomedicine Antibacterial nanomaterials Drug delivery Antibiotic resistance |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425003801 |
| work_keys_str_mv | AT shiwang targetednanomedicinesforthetreatmentofhelicobacterpyloriinfection AT haoding targetednanomedicinesforthetreatmentofhelicobacterpyloriinfection AT longsongli targetednanomedicinesforthetreatmentofhelicobacterpyloriinfection AT ruifangzhao targetednanomedicinesforthetreatmentofhelicobacterpyloriinfection AT ninglichai targetednanomedicinesforthetreatmentofhelicobacterpyloriinfection |