Oral nutrition supplements and between-meal snacks for nutrition therapy in patients with COPD identified as at nutritional risk: a randomised feasibility trial
Introduction Intervention studies have mainly used oral nutritional supplements (ONS) for the management of patients with chronic obstructive pulmonary disease (COPD) identified as at nutritional risk. In this 12-month randomised feasibility trial, we assessed the (1) feasibility of the recruitment,...
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BMJ Publishing Group
2019-10-01
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| Series: | BMJ Open Respiratory Research |
| Online Access: | https://bmjopenrespres.bmj.com/content/6/1/e000349.full |
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| author | Arora Ros Ingadottir Anne Marie Beck Christine Baldwin Christine Elizabeth Weekes Olof Gudny Geirsdottir Alfons Ramel Thorarinn Gislason Ingibjorg Gunnarsdottir |
| author_facet | Arora Ros Ingadottir Anne Marie Beck Christine Baldwin Christine Elizabeth Weekes Olof Gudny Geirsdottir Alfons Ramel Thorarinn Gislason Ingibjorg Gunnarsdottir |
| author_sort | Arora Ros Ingadottir |
| collection | DOAJ |
| description | Introduction Intervention studies have mainly used oral nutritional supplements (ONS) for the management of patients with chronic obstructive pulmonary disease (COPD) identified as at nutritional risk. In this 12-month randomised feasibility trial, we assessed the (1) feasibility of the recruitment, retention and provision of two interventions: ONS and between-meal snacks (snacks) and (2) the potential impact of the provision of snacks and ONS on body weight and quality of life in patients with COPD.Methods Hospitalised patients with COPD, at nutritional risk, were randomised to ONS (n=19) or snacks (n=15) providing 600 kcal and 22 g protein a day in addition to regular daily diet. The intervention started in hospital and was continued for 12 months after discharge from the hospital.Results Study recruitment rate was n=34 (45%) and retention rate at 12 months was similar for both groups: n=13 (68%) in the ONS group and n=10 (67%) in the Snacks group. Both groups gained weight from baseline to 12 months (2.3±4.6 kg (p=0.060) in the ONS group and 4.4±6.4 kg (p=0.030) in the Snacks group). The St George’s Respiratory Questionnaire total score improved from baseline to 12 months in both groups (score 3.9±11.0 (p=0.176) in the ONS group and score 8.9±14.1 (p=0.041) in the Snacks group).Discussion In patients with COPD who are at nutritional risk snacks are at least as feasible and effective as ONS, however, adequately powered trials that take account of the difficulties in recruiting this patient group are required to confirm this effect. |
| format | Article |
| id | doaj-art-a04873aa53af4a7b9888aa1c4e4ffde0 |
| institution | OA Journals |
| issn | 2052-4439 |
| language | English |
| publishDate | 2019-10-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Respiratory Research |
| spelling | doaj-art-a04873aa53af4a7b9888aa1c4e4ffde02025-08-20T02:10:50ZengBMJ Publishing GroupBMJ Open Respiratory Research2052-44392019-10-016110.1136/bmjresp-2018-000349Oral nutrition supplements and between-meal snacks for nutrition therapy in patients with COPD identified as at nutritional risk: a randomised feasibility trialArora Ros Ingadottir0Anne Marie Beck1Christine Baldwin2Christine Elizabeth Weekes3Olof Gudny Geirsdottir4Alfons Ramel5Thorarinn Gislason6Ingibjorg Gunnarsdottir72 Department of Clinical Nutrition, Landspitali University Hospital, Reykjavik, Iceland3 Faculty of Health, Copenhagen University College, Copenhagen, Denmark5 Department of Nutritional Sciences, King`s College London, London, UK5 Department of Nutritional Sciences, King`s College London, London, UK1 Unit for Nutrition Research, Landspitali University Hospital and Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, Iceland1 Unit for Nutrition Research, Landspitali University Hospital and Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, IcelandLandspitali University Hospital, Reykjavik, Iceland1 Unit for Nutrition Research, Landspitali University Hospital and Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, IcelandIntroduction Intervention studies have mainly used oral nutritional supplements (ONS) for the management of patients with chronic obstructive pulmonary disease (COPD) identified as at nutritional risk. In this 12-month randomised feasibility trial, we assessed the (1) feasibility of the recruitment, retention and provision of two interventions: ONS and between-meal snacks (snacks) and (2) the potential impact of the provision of snacks and ONS on body weight and quality of life in patients with COPD.Methods Hospitalised patients with COPD, at nutritional risk, were randomised to ONS (n=19) or snacks (n=15) providing 600 kcal and 22 g protein a day in addition to regular daily diet. The intervention started in hospital and was continued for 12 months after discharge from the hospital.Results Study recruitment rate was n=34 (45%) and retention rate at 12 months was similar for both groups: n=13 (68%) in the ONS group and n=10 (67%) in the Snacks group. Both groups gained weight from baseline to 12 months (2.3±4.6 kg (p=0.060) in the ONS group and 4.4±6.4 kg (p=0.030) in the Snacks group). The St George’s Respiratory Questionnaire total score improved from baseline to 12 months in both groups (score 3.9±11.0 (p=0.176) in the ONS group and score 8.9±14.1 (p=0.041) in the Snacks group).Discussion In patients with COPD who are at nutritional risk snacks are at least as feasible and effective as ONS, however, adequately powered trials that take account of the difficulties in recruiting this patient group are required to confirm this effect.https://bmjopenrespres.bmj.com/content/6/1/e000349.full |
| spellingShingle | Arora Ros Ingadottir Anne Marie Beck Christine Baldwin Christine Elizabeth Weekes Olof Gudny Geirsdottir Alfons Ramel Thorarinn Gislason Ingibjorg Gunnarsdottir Oral nutrition supplements and between-meal snacks for nutrition therapy in patients with COPD identified as at nutritional risk: a randomised feasibility trial BMJ Open Respiratory Research |
| title | Oral nutrition supplements and between-meal snacks for nutrition therapy in patients with COPD identified as at nutritional risk: a randomised feasibility trial |
| title_full | Oral nutrition supplements and between-meal snacks for nutrition therapy in patients with COPD identified as at nutritional risk: a randomised feasibility trial |
| title_fullStr | Oral nutrition supplements and between-meal snacks for nutrition therapy in patients with COPD identified as at nutritional risk: a randomised feasibility trial |
| title_full_unstemmed | Oral nutrition supplements and between-meal snacks for nutrition therapy in patients with COPD identified as at nutritional risk: a randomised feasibility trial |
| title_short | Oral nutrition supplements and between-meal snacks for nutrition therapy in patients with COPD identified as at nutritional risk: a randomised feasibility trial |
| title_sort | oral nutrition supplements and between meal snacks for nutrition therapy in patients with copd identified as at nutritional risk a randomised feasibility trial |
| url | https://bmjopenrespres.bmj.com/content/6/1/e000349.full |
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