Oleic acid activates TGFβ-Smad3 signaling to promote ovarian cancer progression

Oleic acid activates TGFβ-Smad3 signaling to promote ovarian cancer progression

Abstract Background Ovarian cancer represents the most aggressive and lethal gynecological cancer, frequently demonstrating a distinct propensity for abdominal metastasis. Malignant ascites caused by abdominal metastasis provide a tumor microenvironment (TME) in ovarian cancer. Notably, oleic acid i...

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Bibliographic Details
Main Authors: Zhengyang Guo, Yinjia Li, Yunyun Guo, Aosong Zhang, Xiao Huo, Ying Song, Bing Li, Yuanjun Tang, Tianhui He, Tong Liu, Lixiang Xue, Yi Qu, Jiagui Song
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Ovarian Research
Subjects:
Ovarian cancer
Oleic acid
SCD1
Epithelial-mesenchymal transition
TGFβ-Smad3 signaling
Online Access:https://doi.org/10.1186/s13048-025-01763-7
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