European Guideline on IgG4-related Digestive Disease — UEG and SGF Evidence-based Recommendations
The overall objective of these guidelines is to provide evidence-based recommendations for the diagnosis and management of immunoglobulin G4 (IgG4)-related digestive disease in adults and children. IgG4-related digestive disease can be diagnosed only with a comprehensive work-up that includes histol...
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2021-04-01
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| Online Access: | https://www.gastro-j.ru/jour/article/view/561 |
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| author | J.-M. Lohr U. Beuers M. Vujasinovic D. Alvaro J. B. Frøkjær F. Buttgereit G. Capurso E. L. Culver E. de-Madaria E. Della-Torre S. Detlefsen E. Dominguez-Munoz P. Czubkowski N. Ewald L. Frulloni N. Gubergrits D. G. Duman Th. Hackert J. Iglesias-Garcia N. Kartalis A. Laghi F. Lammert F. Lindgren A. Okhlobystin G. Oracz A. Parniczky R. M. P. Mucelli V. Rebours J. Rosendahl N. Schleinitz A. Schneider E. FH van Bommel C. S. Verbeke M. P. Vullierme H. Witt the UEG guideline working group |
| author_facet | J.-M. Lohr U. Beuers M. Vujasinovic D. Alvaro J. B. Frøkjær F. Buttgereit G. Capurso E. L. Culver E. de-Madaria E. Della-Torre S. Detlefsen E. Dominguez-Munoz P. Czubkowski N. Ewald L. Frulloni N. Gubergrits D. G. Duman Th. Hackert J. Iglesias-Garcia N. Kartalis A. Laghi F. Lammert F. Lindgren A. Okhlobystin G. Oracz A. Parniczky R. M. P. Mucelli V. Rebours J. Rosendahl N. Schleinitz A. Schneider E. FH van Bommel C. S. Verbeke M. P. Vullierme H. Witt the UEG guideline working group |
| author_sort | J.-M. Lohr |
| collection | DOAJ |
| description | The overall objective of these guidelines is to provide evidence-based recommendations for the diagnosis and management of immunoglobulin G4 (IgG4)-related digestive disease in adults and children. IgG4-related digestive disease can be diagnosed only with a comprehensive work-up that includes histology, organ morphology at imaging, serology, search for other organ involvement, and response to glucocorticoid treatment. Indications for treatment are symptomatic patients with obstructive jaundice, abdominal pain, posterior pancreatic pain, and involvement of extra-pancreatic digestive organs, including IgG4-related cholangitis. Treatment with glucocorticoids should be weight-based and initiated at a dose of 0.6-0.8 mg/kg body weight/day orally (typical starting dose 30-40 mg/day prednisone equivalent) for 1 month to induce remission and then be tapered within two additional months. Response to initial treatment should be assessed at week 2-4 with clinical, biochemical and morphological markers. Maintenance treatment with glucocorticoids should be considered in multi-organ disease or history of relapse. If there is no change in disease activity and burden within 3 months, the diagnosis should be reconsidered. If the disease relapsed during the 3 months of treatment, immunosuppressive drugs should be added. |
| format | Article |
| id | doaj-art-a041ede29ff947239e20fb7d20b7781d |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2021-04-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-a041ede29ff947239e20fb7d20b7781d2025-02-10T16:14:36ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732021-04-0131180114416European Guideline on IgG4-related Digestive Disease — UEG and SGF Evidence-based RecommendationsJ.-M. Lohr0U. Beuers1M. Vujasinovic2D. Alvaro3J. B. Frøkjær4F. Buttgereit5G. Capurso6E. L. Culver7E. de-Madaria8E. Della-Torre9S. Detlefsen10E. Dominguez-Munoz11P. Czubkowski12N. Ewald13L. Frulloni14N. Gubergrits15D. G. Duman16Th. Hackert17J. Iglesias-Garcia18N. Kartalis19A. Laghi20F. Lammert21F. Lindgren22A. Okhlobystin23G. Oracz24A. Parniczky25R. M. P. Mucelli26V. Rebours27J. Rosendahl28N. Schleinitz29A. Schneider30E. FH van Bommel31C. S. Verbeke32M. P. Vullierme33H. Witt34the UEG guideline working groupDepartment of Upper Gastrointestinal Diseases, Karolinska University Hospital; Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska InstitutetDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Centers, location AMCDepartment of Upper Gastrointestinal Diseases, Karolinska University Hospital, Sweden and Department of Medicine Huddinge, Karolinska InstitutetDepartment of Translational and Precision Medicine, Sapienza University of RomeDepartment of Radiology, Aalborg University HospitalDepartment of Rheumatology and Clinical Immunology, Charite University Medicine BerlinPancreatoBiliary Endoscopy and EUS Division Pancreas Translational and Clinical Research Center IRCCS San Raffaele Scientific InstituteTranslational Gastroenterology Unit, John Radcliffe Hospital and Nuffield Department of Medicine, University of OxfordGastroenterology Department, Alicante University General Hospital, ISABIALSchool of Medicine, Vita-Salute San Raffaele University; Unit of Immunology, Rheumatology, Allergy and Rare Disease (UnIRAR), IRCCS San Raffaele Scientific InstituteDepartment of Pathology, Odense Pancreas Center (OPAC), Odense University HospitalDepartment of Gastroenterology and Hepatology, University Hospital of Santiago de CompostelaDepartment of Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children’s Memorial Health InstituteInstitute of Endocrinology, Diabetology and Metabolism, Johannes Wesling University hospital, Minden, Germany and Justus Liebig University GiessenDepartment of Medicine, Pancreas Institute, University of VeronaDepartment of Internal Medicine, Donetsk National Medical UniversityDepartment of Gastroenterology, School of Medicine, Marmara UniversityDepartment of General, Visceral and Transplantation Surgery, University of HeidelbergDepartment of Gastroenterology and Hepatology, University Hospital of Santiago de CompostelaDepartment of Abdominal Radiology, Karolinska University HospitalDepartment of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome, Sant’Andrea HospitalDepartment of Medicine II, Saarland University Medical CenterDepartment of Pediatric Gastroenterology, Hepatology and Nutrition, Karolinska University HospitalI.M. Sechenov First Moscow State Medical UniversityDepartment of Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children’s Memorial Health InstituteInstitute for Translational Medicine, Szenta'gothai Research Centre, Medical School, University of Pecs; Heim Pál National Insitute of PediatricsDepartment of Abdominal Radiology, Karolinska University HospitalPancreatology Department, Beaujon Hospital, Clichy, Universite de ParisDepartment of Internal Medicine I, Martin Luther UniversityDepartement de Medicine Interne Timone, Assistance Publique-Hôpitaux de Marseille, Aix-Marseille UniversiteDepartment of Gastroenterology and Hepatology, Klinikum Bad HersfeldDepartment of Internal Medicine, Dutch National Center of Expertise Retroperitoneal Fibrosis, Albert Schweitzer hospitalDepartment of Pathology, Oslo University Hospital, and University of OsloRadiology Department, Beaujon HospitalElse Kröner-Fresenius-Zentrum für Ernährungsmedizin, Paediatric Nutritional Medicine, Technische Universität MünchenThe overall objective of these guidelines is to provide evidence-based recommendations for the diagnosis and management of immunoglobulin G4 (IgG4)-related digestive disease in adults and children. IgG4-related digestive disease can be diagnosed only with a comprehensive work-up that includes histology, organ morphology at imaging, serology, search for other organ involvement, and response to glucocorticoid treatment. Indications for treatment are symptomatic patients with obstructive jaundice, abdominal pain, posterior pancreatic pain, and involvement of extra-pancreatic digestive organs, including IgG4-related cholangitis. Treatment with glucocorticoids should be weight-based and initiated at a dose of 0.6-0.8 mg/kg body weight/day orally (typical starting dose 30-40 mg/day prednisone equivalent) for 1 month to induce remission and then be tapered within two additional months. Response to initial treatment should be assessed at week 2-4 with clinical, biochemical and morphological markers. Maintenance treatment with glucocorticoids should be considered in multi-organ disease or history of relapse. If there is no change in disease activity and burden within 3 months, the diagnosis should be reconsidered. If the disease relapsed during the 3 months of treatment, immunosuppressive drugs should be added.https://www.gastro-j.ru/jour/article/view/561igg4-relateddigestivediseaseglucocorticoidsother organ involvementbiomarkersautoimmune pancreatitis type 1immune-related cholangitiscancerdiabetes mellitus |
| spellingShingle | J.-M. Lohr U. Beuers M. Vujasinovic D. Alvaro J. B. Frøkjær F. Buttgereit G. Capurso E. L. Culver E. de-Madaria E. Della-Torre S. Detlefsen E. Dominguez-Munoz P. Czubkowski N. Ewald L. Frulloni N. Gubergrits D. G. Duman Th. Hackert J. Iglesias-Garcia N. Kartalis A. Laghi F. Lammert F. Lindgren A. Okhlobystin G. Oracz A. Parniczky R. M. P. Mucelli V. Rebours J. Rosendahl N. Schleinitz A. Schneider E. FH van Bommel C. S. Verbeke M. P. Vullierme H. Witt the UEG guideline working group European Guideline on IgG4-related Digestive Disease — UEG and SGF Evidence-based Recommendations Российский журнал гастроэнтерологии, гепатологии, колопроктологии igg4-related digestive disease glucocorticoids other organ involvement biomarkers autoimmune pancreatitis type 1 immune-related cholangitis cancer diabetes mellitus |
| title | European Guideline on IgG4-related Digestive Disease — UEG and SGF Evidence-based Recommendations |
| title_full | European Guideline on IgG4-related Digestive Disease — UEG and SGF Evidence-based Recommendations |
| title_fullStr | European Guideline on IgG4-related Digestive Disease — UEG and SGF Evidence-based Recommendations |
| title_full_unstemmed | European Guideline on IgG4-related Digestive Disease — UEG and SGF Evidence-based Recommendations |
| title_short | European Guideline on IgG4-related Digestive Disease — UEG and SGF Evidence-based Recommendations |
| title_sort | european guideline on igg4 related digestive disease ueg and sgf evidence based recommendations |
| topic | igg4-related digestive disease glucocorticoids other organ involvement biomarkers autoimmune pancreatitis type 1 immune-related cholangitis cancer diabetes mellitus |
| url | https://www.gastro-j.ru/jour/article/view/561 |
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