Exploring the frontier of lung alveolar regeneration: Cellular dynamics, aging effects, and emerging therapeutics
Structured abstract: Background: Alveolar regeneration is essential for maintaining lung function and enabling recovery following lung injury. Impairment of this process contributes to the progression of various respiratory diseases. A detailed understanding of the cellular and molecular mechanisms...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-09-01
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| Series: | Translational Research in Anatomy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214854X25000305 |
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| author | Rashid A. Aldahhan Amal Ahmed El-Sheikh |
| author_facet | Rashid A. Aldahhan Amal Ahmed El-Sheikh |
| author_sort | Rashid A. Aldahhan |
| collection | DOAJ |
| description | Structured abstract: Background: Alveolar regeneration is essential for maintaining lung function and enabling recovery following lung injury. Impairment of this process contributes to the progression of various respiratory diseases. A detailed understanding of the cellular and molecular mechanisms driving alveolar repair is crucial for the development of effective therapeutic strategies. Methods: A literature search was conducted in PubMed, Scopus, and Google Scholar focusing on the history of alveolar regeneration and the cells involved in this process, the effects of aging, and associated therapeutic implications. The keywords used in the search included “alveolar regeneration,” “aging,” “cell senescence,” “stem cells,” “growth factors,” and “therapeutic potential.” Results: This review explores the key cellular players involved in alveolar repair, focusing particularly on alveolar type 2 cells and other progenitor populations that contribute to alveolar epithelial renewal. This review also highlights how aging affects regenerative capacity, as age-related cellular dysfunction may impair lung repair and exacerbate chronic pulmonary conditions. Furthermore, novel insights into alveolar regeneration are reviewed, including recent advancements in in vivo and in vitro models as well as single-cell technologies that provide a deeper understanding of the regenerative process. Emerging therapeutic strategies, such as stem cell–based therapies, gene editing, and pharmacological interventions, are also discussed in the context of enhancing alveolar regeneration. Conclusions: By integrating recent discoveries and identifying key knowledge gaps, this review provides a comprehensive overview of alveolar regeneration and emphasizes potential therapeutic approaches for promoting lung repair and restoring respiratory function. |
| format | Article |
| id | doaj-art-a03ff1bf9f124550882c8b3bf56d5860 |
| institution | Kabale University |
| issn | 2214-854X |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Research in Anatomy |
| spelling | doaj-art-a03ff1bf9f124550882c8b3bf56d58602025-08-21T04:16:54ZengElsevierTranslational Research in Anatomy2214-854X2025-09-014010041110.1016/j.tria.2025.100411Exploring the frontier of lung alveolar regeneration: Cellular dynamics, aging effects, and emerging therapeuticsRashid A. Aldahhan0Amal Ahmed El-Sheikh1Corresponding author.; Department of Anatomy, College of Medicine, Imam Abdulrahman Bin Faisal University, P.O. Box 2114, Dammam, 31451, Saudi ArabiaDepartment of Anatomy, College of Medicine, Imam Abdulrahman Bin Faisal University, P.O. Box 2114, Dammam, 31451, Saudi ArabiaStructured abstract: Background: Alveolar regeneration is essential for maintaining lung function and enabling recovery following lung injury. Impairment of this process contributes to the progression of various respiratory diseases. A detailed understanding of the cellular and molecular mechanisms driving alveolar repair is crucial for the development of effective therapeutic strategies. Methods: A literature search was conducted in PubMed, Scopus, and Google Scholar focusing on the history of alveolar regeneration and the cells involved in this process, the effects of aging, and associated therapeutic implications. The keywords used in the search included “alveolar regeneration,” “aging,” “cell senescence,” “stem cells,” “growth factors,” and “therapeutic potential.” Results: This review explores the key cellular players involved in alveolar repair, focusing particularly on alveolar type 2 cells and other progenitor populations that contribute to alveolar epithelial renewal. This review also highlights how aging affects regenerative capacity, as age-related cellular dysfunction may impair lung repair and exacerbate chronic pulmonary conditions. Furthermore, novel insights into alveolar regeneration are reviewed, including recent advancements in in vivo and in vitro models as well as single-cell technologies that provide a deeper understanding of the regenerative process. Emerging therapeutic strategies, such as stem cell–based therapies, gene editing, and pharmacological interventions, are also discussed in the context of enhancing alveolar regeneration. Conclusions: By integrating recent discoveries and identifying key knowledge gaps, this review provides a comprehensive overview of alveolar regeneration and emphasizes potential therapeutic approaches for promoting lung repair and restoring respiratory function.http://www.sciencedirect.com/science/article/pii/S2214854X25000305Alveolar regenerationAgingCell senescenceStem cellsGrowth factorsTherapeutic potential |
| spellingShingle | Rashid A. Aldahhan Amal Ahmed El-Sheikh Exploring the frontier of lung alveolar regeneration: Cellular dynamics, aging effects, and emerging therapeutics Translational Research in Anatomy Alveolar regeneration Aging Cell senescence Stem cells Growth factors Therapeutic potential |
| title | Exploring the frontier of lung alveolar regeneration: Cellular dynamics, aging effects, and emerging therapeutics |
| title_full | Exploring the frontier of lung alveolar regeneration: Cellular dynamics, aging effects, and emerging therapeutics |
| title_fullStr | Exploring the frontier of lung alveolar regeneration: Cellular dynamics, aging effects, and emerging therapeutics |
| title_full_unstemmed | Exploring the frontier of lung alveolar regeneration: Cellular dynamics, aging effects, and emerging therapeutics |
| title_short | Exploring the frontier of lung alveolar regeneration: Cellular dynamics, aging effects, and emerging therapeutics |
| title_sort | exploring the frontier of lung alveolar regeneration cellular dynamics aging effects and emerging therapeutics |
| topic | Alveolar regeneration Aging Cell senescence Stem cells Growth factors Therapeutic potential |
| url | http://www.sciencedirect.com/science/article/pii/S2214854X25000305 |
| work_keys_str_mv | AT rashidaaldahhan exploringthefrontieroflungalveolarregenerationcellulardynamicsagingeffectsandemergingtherapeutics AT amalahmedelsheikh exploringthefrontieroflungalveolarregenerationcellulardynamicsagingeffectsandemergingtherapeutics |