T Lymphocyte Autoreactivity in Inflammatory Mechanisms Regulating Atherosclerosis
Atherosclerosis has been clearly demonstrated to be a chronic inflammatory disease of the arterial wall. Both cells of the innate and the acquired immune system, particularly monocytes and T lymphocytes, are implicated in the atherogenic process, producing different cytokines with pro- and anti-infl...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/157534 |
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| author | Elisabetta Profumo Brigitta Buttari Luciano Saso Raffaele Capoano Bruno Salvati Rachele Riganò |
| author_facet | Elisabetta Profumo Brigitta Buttari Luciano Saso Raffaele Capoano Bruno Salvati Rachele Riganò |
| author_sort | Elisabetta Profumo |
| collection | DOAJ |
| description | Atherosclerosis has been clearly demonstrated to be a chronic inflammatory disease of the arterial wall. Both cells of the innate and the acquired immune system, particularly monocytes and T lymphocytes, are implicated in the atherogenic process, producing different cytokines with pro- and anti-inflammatory effects. The majority of pathogenic T cells involved in atherosclerosis are of the Th1 profile, that has been correlated positively with coronary artery disease. Many studies conducted to evaluate the molecular factors responsible for the activation of T cells have demonstrated that the main antigenic targets in atherosclerosis are modified endogenous structures. These self-molecules activate autoimmune reactions mainly characterized by the production of Th1 cytokines, thus sustaining the inflammatory mechanisms involved in endothelial dysfunction and plaque development. In this paper we will summarize the different T-cell subsets involved in atherosclerosis and the best characterized autoantigens involved in cardiovascular inflammation. |
| format | Article |
| id | doaj-art-a03baf1dfb9b44ba8d3032d9a871c43b |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-a03baf1dfb9b44ba8d3032d9a871c43b2025-02-03T06:13:00ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/157534157534T Lymphocyte Autoreactivity in Inflammatory Mechanisms Regulating AtherosclerosisElisabetta Profumo0Brigitta Buttari1Luciano Saso2Raffaele Capoano3Bruno Salvati4Rachele Riganò5Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanità, viale Regina Elena 299, 00161 Rome, ItalyDipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanità, viale Regina Elena 299, 00161 Rome, ItalyDipartimento di Fisiologia e Farmacologia “Vittorio Erspamer”, Sapienza Università di Roma, Piazzale Aldo Moro, 00185 Rome, ItalyDipartimento di Scienze Chirurgiche, Policlinico Umberto I, Sapienza Università di Roma, Piazzale Aldo Moro, 00185 Rome, ItalyDipartimento di Scienze Chirurgiche, Policlinico Umberto I, Sapienza Università di Roma, Piazzale Aldo Moro, 00185 Rome, ItalyDipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanità, viale Regina Elena 299, 00161 Rome, ItalyAtherosclerosis has been clearly demonstrated to be a chronic inflammatory disease of the arterial wall. Both cells of the innate and the acquired immune system, particularly monocytes and T lymphocytes, are implicated in the atherogenic process, producing different cytokines with pro- and anti-inflammatory effects. The majority of pathogenic T cells involved in atherosclerosis are of the Th1 profile, that has been correlated positively with coronary artery disease. Many studies conducted to evaluate the molecular factors responsible for the activation of T cells have demonstrated that the main antigenic targets in atherosclerosis are modified endogenous structures. These self-molecules activate autoimmune reactions mainly characterized by the production of Th1 cytokines, thus sustaining the inflammatory mechanisms involved in endothelial dysfunction and plaque development. In this paper we will summarize the different T-cell subsets involved in atherosclerosis and the best characterized autoantigens involved in cardiovascular inflammation.http://dx.doi.org/10.1100/2012/157534 |
| spellingShingle | Elisabetta Profumo Brigitta Buttari Luciano Saso Raffaele Capoano Bruno Salvati Rachele Riganò T Lymphocyte Autoreactivity in Inflammatory Mechanisms Regulating Atherosclerosis The Scientific World Journal |
| title | T Lymphocyte Autoreactivity in Inflammatory Mechanisms Regulating Atherosclerosis |
| title_full | T Lymphocyte Autoreactivity in Inflammatory Mechanisms Regulating Atherosclerosis |
| title_fullStr | T Lymphocyte Autoreactivity in Inflammatory Mechanisms Regulating Atherosclerosis |
| title_full_unstemmed | T Lymphocyte Autoreactivity in Inflammatory Mechanisms Regulating Atherosclerosis |
| title_short | T Lymphocyte Autoreactivity in Inflammatory Mechanisms Regulating Atherosclerosis |
| title_sort | t lymphocyte autoreactivity in inflammatory mechanisms regulating atherosclerosis |
| url | http://dx.doi.org/10.1100/2012/157534 |
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