Antioxidant Effect of Chlorella vulgaris on Physiological Response of Rat Induced by Carbon Tetrachloride
Chlorella vulgaris is an algae with high nutrition content. Carbon tetrachloride (CCl4) is a hepatotoxic chemical.The aims of this study were to determine the effect of C. vulgaris extract on the physiological response of liver such as MDA, SOD and GPx activity on rat after induced by CCl4 exposure...
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Universitas Negeri Semarang
2019-04-01
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| Series: | Biosaintifika: Journal of Biology & Biology Education |
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| Online Access: | https://journal.unnes.ac.id/nju/index.php/biosaintifika/article/view/16393 |
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| author | Hernayanti Hernayanti Sorta Basar Ida Simanjuntak |
| author_facet | Hernayanti Hernayanti Sorta Basar Ida Simanjuntak |
| author_sort | Hernayanti Hernayanti |
| collection | DOAJ |
| description | Chlorella vulgaris is an algae with high nutrition content. Carbon tetrachloride (CCl4) is a hepatotoxic chemical.The aims of this study were to determine the effect of C. vulgaris extract on the physiological response of liver such as MDA, SOD and GPx activity on rat after induced by CCl4 exposure as well as to determine the effective dose of C. vulgaris extract as antioxidant that can neutralize CCl4 exposure. This research was conducted experimentally with Completely Randomized Design that consists of 6 treatment and 5 times repetition. The doses of C. vulgaris extract used were 3, 4, and 5 mg per /100 g of rat’sbody weight (BW).The administration of C. vulgaris extract was performed within 30 days, while the CCl4 (0.25 ml/100 g BW) was administered orally on the day 9, 12, 16, 19, 23, and 26. Parameters measured were levels of MDA, SOD and GPx of rat blood serum.The results showed that the administration of C. vulgaris extract can inhibit lipid peroxidation indicated by decrease in MDA activities and oxidative stress by increasing SOD and GPx activity. In conclusion, 5 mg/100 g BW of C.vulgaris extract is an effective dose to be uses as endogenous antioxidant to protect the liver cell from damage caused by CCl4exposure. The benefit of C. vulgaris as a supplement for antihepatotoxin in humans. |
| format | Article |
| id | doaj-art-a037bd700f194ec785d0995b8215fce2 |
| institution | OA Journals |
| issn | 2085-191X 2338-7610 |
| language | English |
| publishDate | 2019-04-01 |
| publisher | Universitas Negeri Semarang |
| record_format | Article |
| series | Biosaintifika: Journal of Biology & Biology Education |
| spelling | doaj-art-a037bd700f194ec785d0995b8215fce22025-08-20T02:00:39ZengUniversitas Negeri SemarangBiosaintifika: Journal of Biology & Biology Education2085-191X2338-76102019-04-01111849010.15294/biosaintifika.v11i1.163938501Antioxidant Effect of Chlorella vulgaris on Physiological Response of Rat Induced by Carbon TetrachlorideHernayanti Hernayanti0Sorta Basar Ida Simanjuntak1Faculty of Biology, Universitas Jenderal SoedirmanFaculty of Biology, Universitas Jenderal SoedirmanChlorella vulgaris is an algae with high nutrition content. Carbon tetrachloride (CCl4) is a hepatotoxic chemical.The aims of this study were to determine the effect of C. vulgaris extract on the physiological response of liver such as MDA, SOD and GPx activity on rat after induced by CCl4 exposure as well as to determine the effective dose of C. vulgaris extract as antioxidant that can neutralize CCl4 exposure. This research was conducted experimentally with Completely Randomized Design that consists of 6 treatment and 5 times repetition. The doses of C. vulgaris extract used were 3, 4, and 5 mg per /100 g of rat’sbody weight (BW).The administration of C. vulgaris extract was performed within 30 days, while the CCl4 (0.25 ml/100 g BW) was administered orally on the day 9, 12, 16, 19, 23, and 26. Parameters measured were levels of MDA, SOD and GPx of rat blood serum.The results showed that the administration of C. vulgaris extract can inhibit lipid peroxidation indicated by decrease in MDA activities and oxidative stress by increasing SOD and GPx activity. In conclusion, 5 mg/100 g BW of C.vulgaris extract is an effective dose to be uses as endogenous antioxidant to protect the liver cell from damage caused by CCl4exposure. The benefit of C. vulgaris as a supplement for antihepatotoxin in humans.https://journal.unnes.ac.id/nju/index.php/biosaintifika/article/view/16393antioxidantcarbon tetrachloridechlorella vulgaris extracthepatotoxic chemicals |
| spellingShingle | Hernayanti Hernayanti Sorta Basar Ida Simanjuntak Antioxidant Effect of Chlorella vulgaris on Physiological Response of Rat Induced by Carbon Tetrachloride Biosaintifika: Journal of Biology & Biology Education antioxidant carbon tetrachloride chlorella vulgaris extract hepatotoxic chemicals |
| title | Antioxidant Effect of Chlorella vulgaris on Physiological Response of Rat Induced by Carbon Tetrachloride |
| title_full | Antioxidant Effect of Chlorella vulgaris on Physiological Response of Rat Induced by Carbon Tetrachloride |
| title_fullStr | Antioxidant Effect of Chlorella vulgaris on Physiological Response of Rat Induced by Carbon Tetrachloride |
| title_full_unstemmed | Antioxidant Effect of Chlorella vulgaris on Physiological Response of Rat Induced by Carbon Tetrachloride |
| title_short | Antioxidant Effect of Chlorella vulgaris on Physiological Response of Rat Induced by Carbon Tetrachloride |
| title_sort | antioxidant effect of chlorella vulgaris on physiological response of rat induced by carbon tetrachloride |
| topic | antioxidant carbon tetrachloride chlorella vulgaris extract hepatotoxic chemicals |
| url | https://journal.unnes.ac.id/nju/index.php/biosaintifika/article/view/16393 |
| work_keys_str_mv | AT hernayantihernayanti antioxidanteffectofchlorellavulgarisonphysiologicalresponseofratinducedbycarbontetrachloride AT sortabasaridasimanjuntak antioxidanteffectofchlorellavulgarisonphysiologicalresponseofratinducedbycarbontetrachloride |