Design and Development of a Device (Sifilotto<sup>®</sup>) for Tumour Tracking in Cervical Cancer Patients Undergoing Robotic Arm LINAC Stereotactic Body Radiation Therapy Boost: Background to the STARBACS Study
Standard of Care (SOC) for locally advanced cervical cancer is represented by external beam radiation therapy concurrent with platinum-based chemotherapy and immunotherapy (cCIRT) followed by brachytherapy boost and immunotherapy maintenance. In some instances, it is impossible to perform brachyther...
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MDPI AG
2025-06-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/32/6/354 |
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| author | Silvana Parisi Giacomo Ferrantelli Anna Santacaterina Elvio Grazioso Russi Federico Chillari Claudio Napoli Anna Brogna Carmelo Siragusa Miriam Sciacca Antonio Pontoriero Giuseppe Iatì Stefano Pergolizzi |
| author_facet | Silvana Parisi Giacomo Ferrantelli Anna Santacaterina Elvio Grazioso Russi Federico Chillari Claudio Napoli Anna Brogna Carmelo Siragusa Miriam Sciacca Antonio Pontoriero Giuseppe Iatì Stefano Pergolizzi |
| author_sort | Silvana Parisi |
| collection | DOAJ |
| description | Standard of Care (SOC) for locally advanced cervical cancer is represented by external beam radiation therapy concurrent with platinum-based chemotherapy and immunotherapy (cCIRT) followed by brachytherapy boost and immunotherapy maintenance. In some instances, it is impossible to perform brachytherapy due to patient and/or cancer issues. In these circumstances, an external beam boost could be delivered. Using a robotic arm LINAC, it is mandatory to use intramucosal implanted fiducials which are needed for tumour tracking. To avoid invasive procedures, we developed an original intravaginal 3D-printed universal device containing gold fiducials embedded within it. In this paper, we describe the step-by-step procedure that allowed us to obtain the utility model patent, including the in vivo test (feasibility, reproducibility, device compliance) on seven patients within the study protocol “STereotActic Radiotherapy Boost in locally Advanced Cervical carcinoma patientS” (STARBACS). |
| format | Article |
| id | doaj-art-a0345ebe24bc4b78bddfe93eb6b11169 |
| institution | Kabale University |
| issn | 1198-0052 1718-7729 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj-art-a0345ebe24bc4b78bddfe93eb6b111692025-08-20T03:27:06ZengMDPI AGCurrent Oncology1198-00521718-77292025-06-0132635410.3390/curroncol32060354Design and Development of a Device (Sifilotto<sup>®</sup>) for Tumour Tracking in Cervical Cancer Patients Undergoing Robotic Arm LINAC Stereotactic Body Radiation Therapy Boost: Background to the STARBACS StudySilvana Parisi0Giacomo Ferrantelli1Anna Santacaterina2Elvio Grazioso Russi3Federico Chillari4Claudio Napoli5Anna Brogna6Carmelo Siragusa7Miriam Sciacca8Antonio Pontoriero9Giuseppe Iatì10Stefano Pergolizzi11Department of Biomedical Dental and Morphological and Functional Imaging (BIOMORF), Residency School of Radiation Oncology, University of Messina, Via Consolare Valeria 1, 98124 Messina, ItalyDepartment of Biomedical Dental and Morphological and Functional Imaging (BIOMORF), Residency School of Radiation Oncology, University of Messina, Via Consolare Valeria 1, 98124 Messina, ItalyDepartment of Biomedical Dental and Morphological and Functional Imaging (BIOMORF), Residency School of Radiation Oncology, University of Messina, Via Consolare Valeria 1, 98124 Messina, ItalyDepartment of Biomedical Dental and Morphological and Functional Imaging (BIOMORF), Residency School of Radiation Oncology, University of Messina, Via Consolare Valeria 1, 98124 Messina, ItalyRadiotherapy Unit, “Villa Santa Teresa Diagnostica Per Immagini e Radioterapia”, Viale Ing. G. Bagnera 14, 90011 Bagheria, ItalyDepartment of Biomedical Dental and Morphological and Functional Imaging (BIOMORF), Residency School of Radiation Oncology, University of Messina, Via Consolare Valeria 1, 98124 Messina, Italy“D.A.I Servizi” Department, COU Medical Physics, University Hospital “AOU G. Martino”, Via Consolare Valeria 1, 98124 Messina, Italy“D.A.I Servizi” Department, COU Medical Physics, University Hospital “AOU G. Martino”, Via Consolare Valeria 1, 98124 Messina, ItalyDepartment of Biomedical Dental and Morphological and Functional Imaging (BIOMORF), Residency School of Radiation Oncology, University of Messina, Via Consolare Valeria 1, 98124 Messina, ItalyDepartment of Biomedical Dental and Morphological and Functional Imaging (BIOMORF), Residency School of Radiation Oncology, University of Messina, Via Consolare Valeria 1, 98124 Messina, ItalyDepartment of Biomedical Dental and Morphological and Functional Imaging (BIOMORF), Residency School of Radiation Oncology, University of Messina, Via Consolare Valeria 1, 98124 Messina, ItalyDepartment of Biomedical Dental and Morphological and Functional Imaging (BIOMORF), Residency School of Radiation Oncology, University of Messina, Via Consolare Valeria 1, 98124 Messina, ItalyStandard of Care (SOC) for locally advanced cervical cancer is represented by external beam radiation therapy concurrent with platinum-based chemotherapy and immunotherapy (cCIRT) followed by brachytherapy boost and immunotherapy maintenance. In some instances, it is impossible to perform brachytherapy due to patient and/or cancer issues. In these circumstances, an external beam boost could be delivered. Using a robotic arm LINAC, it is mandatory to use intramucosal implanted fiducials which are needed for tumour tracking. To avoid invasive procedures, we developed an original intravaginal 3D-printed universal device containing gold fiducials embedded within it. In this paper, we describe the step-by-step procedure that allowed us to obtain the utility model patent, including the in vivo test (feasibility, reproducibility, device compliance) on seven patients within the study protocol “STereotActic Radiotherapy Boost in locally Advanced Cervical carcinoma patientS” (STARBACS).https://www.mdpi.com/1718-7729/32/6/354cervical cancerbrachytherapyendovaginal applicatorlocally advancedstereotacticrobotic LINAC |
| spellingShingle | Silvana Parisi Giacomo Ferrantelli Anna Santacaterina Elvio Grazioso Russi Federico Chillari Claudio Napoli Anna Brogna Carmelo Siragusa Miriam Sciacca Antonio Pontoriero Giuseppe Iatì Stefano Pergolizzi Design and Development of a Device (Sifilotto<sup>®</sup>) for Tumour Tracking in Cervical Cancer Patients Undergoing Robotic Arm LINAC Stereotactic Body Radiation Therapy Boost: Background to the STARBACS Study Current Oncology cervical cancer brachytherapy endovaginal applicator locally advanced stereotactic robotic LINAC |
| title | Design and Development of a Device (Sifilotto<sup>®</sup>) for Tumour Tracking in Cervical Cancer Patients Undergoing Robotic Arm LINAC Stereotactic Body Radiation Therapy Boost: Background to the STARBACS Study |
| title_full | Design and Development of a Device (Sifilotto<sup>®</sup>) for Tumour Tracking in Cervical Cancer Patients Undergoing Robotic Arm LINAC Stereotactic Body Radiation Therapy Boost: Background to the STARBACS Study |
| title_fullStr | Design and Development of a Device (Sifilotto<sup>®</sup>) for Tumour Tracking in Cervical Cancer Patients Undergoing Robotic Arm LINAC Stereotactic Body Radiation Therapy Boost: Background to the STARBACS Study |
| title_full_unstemmed | Design and Development of a Device (Sifilotto<sup>®</sup>) for Tumour Tracking in Cervical Cancer Patients Undergoing Robotic Arm LINAC Stereotactic Body Radiation Therapy Boost: Background to the STARBACS Study |
| title_short | Design and Development of a Device (Sifilotto<sup>®</sup>) for Tumour Tracking in Cervical Cancer Patients Undergoing Robotic Arm LINAC Stereotactic Body Radiation Therapy Boost: Background to the STARBACS Study |
| title_sort | design and development of a device sifilotto sup r sup for tumour tracking in cervical cancer patients undergoing robotic arm linac stereotactic body radiation therapy boost background to the starbacs study |
| topic | cervical cancer brachytherapy endovaginal applicator locally advanced stereotactic robotic LINAC |
| url | https://www.mdpi.com/1718-7729/32/6/354 |
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