Oral microbiota shifts following tooth loss affect gut health
Abstract Background Tooth loss not only impairs oral function but also affects gut health by altering the host microbiota. Understanding the oral-gut axis can provide insights into systemic health implications following tooth loss. Methods Using an animal model, we extracted the molars of C57 mice....
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-025-05581-7 |
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| author | Ling Dong Zhaoxin Ji Jiangqi Hu Qingsong Jiang Wei Wei |
| author_facet | Ling Dong Zhaoxin Ji Jiangqi Hu Qingsong Jiang Wei Wei |
| author_sort | Ling Dong |
| collection | DOAJ |
| description | Abstract Background Tooth loss not only impairs oral function but also affects gut health by altering the host microbiota. Understanding the oral-gut axis can provide insights into systemic health implications following tooth loss. Methods Using an animal model, we extracted the molars of C57 mice. Saliva and fecal samples were collected for 16S rRNA and metagenomic sequencing to analyze changes in the oral and gut microbiota. Pearson correlation analysis assessed the relationship between altered microbial communities. Results The study found a significant reduction in oral microbiota diversity following tooth loss, with increased Proteobacteria and decreased Muribacter. Gut microbiota showed increased Firmicutes and decreased Bacteroidota. Correlations between oral and gut microbiota changes were observed, indicating a potential link between tooth loss and alterations in intestinal microbial balance. Conclusion In the mouse model, tooth loss disrupted the balance of the oral-gut microbiota, with potential implications for intestinal health. Although these findings are from a murine model, considering the existence of the oral-gut axis balance in the human body, it is reasonable to postulate that following tooth loss in humans, the health of the intestinal microecology may also warrant attention. |
| format | Article |
| id | doaj-art-a032f934711641d9a77b058a8359d2a3 |
| institution | DOAJ |
| issn | 1472-6831 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj-art-a032f934711641d9a77b058a8359d2a32025-08-20T02:43:16ZengBMCBMC Oral Health1472-68312025-02-0125111110.1186/s12903-025-05581-7Oral microbiota shifts following tooth loss affect gut healthLing Dong0Zhaoxin Ji1Jiangqi Hu2Qingsong Jiang3Wei Wei4Department of Prosthodontics, School of Stomatology, Beijing Stomatological Hospital, Capital Medical UniversityDepartment of Prosthodontics, School of Stomatology, Beijing Stomatological Hospital, Capital Medical UniversityDepartment of Prosthodontics, School of Stomatology, Beijing Stomatological Hospital, Capital Medical UniversityDepartment of Prosthodontics, School of Stomatology, Beijing Stomatological Hospital, Capital Medical UniversityDepartment of Prosthodontics, School of Stomatology, Beijing Stomatological Hospital, Capital Medical UniversityAbstract Background Tooth loss not only impairs oral function but also affects gut health by altering the host microbiota. Understanding the oral-gut axis can provide insights into systemic health implications following tooth loss. Methods Using an animal model, we extracted the molars of C57 mice. Saliva and fecal samples were collected for 16S rRNA and metagenomic sequencing to analyze changes in the oral and gut microbiota. Pearson correlation analysis assessed the relationship between altered microbial communities. Results The study found a significant reduction in oral microbiota diversity following tooth loss, with increased Proteobacteria and decreased Muribacter. Gut microbiota showed increased Firmicutes and decreased Bacteroidota. Correlations between oral and gut microbiota changes were observed, indicating a potential link between tooth loss and alterations in intestinal microbial balance. Conclusion In the mouse model, tooth loss disrupted the balance of the oral-gut microbiota, with potential implications for intestinal health. Although these findings are from a murine model, considering the existence of the oral-gut axis balance in the human body, it is reasonable to postulate that following tooth loss in humans, the health of the intestinal microecology may also warrant attention.https://doi.org/10.1186/s12903-025-05581-7Oral MicrobiotaGut microbiotaOral‑gut microbiome axisTooth Loss |
| spellingShingle | Ling Dong Zhaoxin Ji Jiangqi Hu Qingsong Jiang Wei Wei Oral microbiota shifts following tooth loss affect gut health BMC Oral Health Oral Microbiota Gut microbiota Oral‑gut microbiome axis Tooth Loss |
| title | Oral microbiota shifts following tooth loss affect gut health |
| title_full | Oral microbiota shifts following tooth loss affect gut health |
| title_fullStr | Oral microbiota shifts following tooth loss affect gut health |
| title_full_unstemmed | Oral microbiota shifts following tooth loss affect gut health |
| title_short | Oral microbiota shifts following tooth loss affect gut health |
| title_sort | oral microbiota shifts following tooth loss affect gut health |
| topic | Oral Microbiota Gut microbiota Oral‑gut microbiome axis Tooth Loss |
| url | https://doi.org/10.1186/s12903-025-05581-7 |
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