Development of a multi-year pediatric antibiogram in Georgia identifies antibiotic resistance changes over the past ten years
Abstract Background: Antibiograms monitor antibiotic resistance trends and help guide empiric antibiotic treatment. A statewide pediatric antibiogram can help inform stewardship efforts. Methods: Annual pediatric antibiograms for the five children’s hospitals in Georgia from 2014–2023 were colle...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2025-01-01
|
| Series: | Antimicrobial Stewardship & Healthcare Epidemiology |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2732494X25000324/type/journal_article |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850199341917011968 |
|---|---|
| author | Matthew Linam Madeleine Goldstein Tracy Huang Adrianna Westbrook Robert C. Jerris Mark D. Gonzalez |
| author_facet | Matthew Linam Madeleine Goldstein Tracy Huang Adrianna Westbrook Robert C. Jerris Mark D. Gonzalez |
| author_sort | Matthew Linam |
| collection | DOAJ |
| description |
Abstract
Background:
Antibiograms monitor antibiotic resistance trends and help guide empiric antibiotic treatment. A statewide pediatric antibiogram can help inform stewardship efforts.
Methods:
Annual pediatric antibiograms for the five children’s hospitals in Georgia from 2014–2023 were collected. All sites used the Clinical and Laboratory Standards Institute guidelines for antibiogram development. Antibiogram data were combined, and the most common bacteria were included: Staphylococcus aureus, Streptococcus pneumoniae, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae complex and Pseudomonas aeruginosa. Interhospital differences were compared for methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. aureus (MRSA), E. coli and K. pneumoniae. The combined data from 2014 and 2023 were compared to demonstrate antibiotic susceptibility changes over time.
Results:
Data in 2023 for MSSA and MRSA showed clindamycin susceptibility was 78% and 82%, respectively. S. pneumoniae susceptibility to amoxicillin/clavulanate was 96%. E. faecalis resistance to ampicillin and vancomycin was rare. For all included gram-negative bacteria, susceptibility remained high to 3rd generation cephalosporins (90%–92%) and meropenem (95%–99%). From 2014 to 2023, the rate of MRSA decreased from 49% to 33.5%. S. pneumoniae susceptibility to amoxicillin/clavulanate and clindamycin significantly increased. For E. coli, there was a significant decrease in susceptibility for cefazolin (90% to 84%), ceftriaxone (95% to 92%), and meropenem (100% to 99%). There were nonsignificant decreases in susceptibility for K. pneumoniae.
Conclusion:
Over the past 10 years, MRSA rates decreased, S. pneumoniae antibiotic susceptibility increased, and gram-negative bacilli susceptibility was stable to slightly decreased. Georgia antibiogram data support the recommended antibiotic treatment for common pediatric infections.
|
| format | Article |
| id | doaj-art-a02ec1932cab40aeac008f2b8992781d |
| institution | OA Journals |
| issn | 2732-494X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Antimicrobial Stewardship & Healthcare Epidemiology |
| spelling | doaj-art-a02ec1932cab40aeac008f2b8992781d2025-08-20T02:12:38ZengCambridge University PressAntimicrobial Stewardship & Healthcare Epidemiology2732-494X2025-01-01510.1017/ash.2025.32Development of a multi-year pediatric antibiogram in Georgia identifies antibiotic resistance changes over the past ten yearsMatthew Linam0https://orcid.org/0000-0002-5157-7286Madeleine Goldstein1https://orcid.org/0000-0002-5389-2597Tracy Huang2Adrianna Westbrook3https://orcid.org/0000-0001-9309-6205Robert C. Jerris4https://orcid.org/0000-0003-0272-4646Mark D. Gonzalez5Division of Pediatric Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA Children’s Healthcare of Atlanta, Atlanta, GA, USADivision of Pediatric Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA Children’s Healthcare of Atlanta, Atlanta, GA, USAPediatric Biostatistics Core, Department of Pediatrics, Emory University, Atlanta, GA, USAPediatric Biostatistics Core, Department of Pediatrics, Emory University, Atlanta, GA, USAChildren’s Healthcare of Atlanta, Atlanta, GA, USA Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USAChildren’s Healthcare of Atlanta, Atlanta, GA, USA Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA Abstract Background: Antibiograms monitor antibiotic resistance trends and help guide empiric antibiotic treatment. A statewide pediatric antibiogram can help inform stewardship efforts. Methods: Annual pediatric antibiograms for the five children’s hospitals in Georgia from 2014–2023 were collected. All sites used the Clinical and Laboratory Standards Institute guidelines for antibiogram development. Antibiogram data were combined, and the most common bacteria were included: Staphylococcus aureus, Streptococcus pneumoniae, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae complex and Pseudomonas aeruginosa. Interhospital differences were compared for methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. aureus (MRSA), E. coli and K. pneumoniae. The combined data from 2014 and 2023 were compared to demonstrate antibiotic susceptibility changes over time. Results: Data in 2023 for MSSA and MRSA showed clindamycin susceptibility was 78% and 82%, respectively. S. pneumoniae susceptibility to amoxicillin/clavulanate was 96%. E. faecalis resistance to ampicillin and vancomycin was rare. For all included gram-negative bacteria, susceptibility remained high to 3rd generation cephalosporins (90%–92%) and meropenem (95%–99%). From 2014 to 2023, the rate of MRSA decreased from 49% to 33.5%. S. pneumoniae susceptibility to amoxicillin/clavulanate and clindamycin significantly increased. For E. coli, there was a significant decrease in susceptibility for cefazolin (90% to 84%), ceftriaxone (95% to 92%), and meropenem (100% to 99%). There were nonsignificant decreases in susceptibility for K. pneumoniae. Conclusion: Over the past 10 years, MRSA rates decreased, S. pneumoniae antibiotic susceptibility increased, and gram-negative bacilli susceptibility was stable to slightly decreased. Georgia antibiogram data support the recommended antibiotic treatment for common pediatric infections. https://www.cambridge.org/core/product/identifier/S2732494X25000324/type/journal_article |
| spellingShingle | Matthew Linam Madeleine Goldstein Tracy Huang Adrianna Westbrook Robert C. Jerris Mark D. Gonzalez Development of a multi-year pediatric antibiogram in Georgia identifies antibiotic resistance changes over the past ten years Antimicrobial Stewardship & Healthcare Epidemiology |
| title | Development of a multi-year pediatric antibiogram in Georgia identifies antibiotic resistance changes over the past ten years |
| title_full | Development of a multi-year pediatric antibiogram in Georgia identifies antibiotic resistance changes over the past ten years |
| title_fullStr | Development of a multi-year pediatric antibiogram in Georgia identifies antibiotic resistance changes over the past ten years |
| title_full_unstemmed | Development of a multi-year pediatric antibiogram in Georgia identifies antibiotic resistance changes over the past ten years |
| title_short | Development of a multi-year pediatric antibiogram in Georgia identifies antibiotic resistance changes over the past ten years |
| title_sort | development of a multi year pediatric antibiogram in georgia identifies antibiotic resistance changes over the past ten years |
| url | https://www.cambridge.org/core/product/identifier/S2732494X25000324/type/journal_article |
| work_keys_str_mv | AT matthewlinam developmentofamultiyearpediatricantibiogramingeorgiaidentifiesantibioticresistancechangesoverthepasttenyears AT madeleinegoldstein developmentofamultiyearpediatricantibiogramingeorgiaidentifiesantibioticresistancechangesoverthepasttenyears AT tracyhuang developmentofamultiyearpediatricantibiogramingeorgiaidentifiesantibioticresistancechangesoverthepasttenyears AT adriannawestbrook developmentofamultiyearpediatricantibiogramingeorgiaidentifiesantibioticresistancechangesoverthepasttenyears AT robertcjerris developmentofamultiyearpediatricantibiogramingeorgiaidentifiesantibioticresistancechangesoverthepasttenyears AT markdgonzalez developmentofamultiyearpediatricantibiogramingeorgiaidentifiesantibioticresistancechangesoverthepasttenyears |