A Case of Systemic Lupus Erythematosus diagnosed on bone marrow aspiration
Abstract: Lupus erythematosus (LE) cell phenomenon was demonstrated in patients with systemic lupus erythematosus (SLE) in 1948. Now-a-days, antinuclear antibody testing (ANA) in...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2014-08-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | https://mjhid.org/index.php/mjhid/article/view/1937 |
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| author | Mukta Pujani Shivani Kushwaha Neha Sethi Anu Beniwal Shailaja Shukla |
| author_facet | Mukta Pujani Shivani Kushwaha Neha Sethi Anu Beniwal Shailaja Shukla |
| author_sort | Mukta Pujani |
| collection | DOAJ |
| description | Abstract:
Lupus erythematosus (LE) cell phenomenon was demonstrated in patients with systemic lupus erythematosus (SLE) in 1948. Now-a-days, antinuclear antibody testing (ANA) including the specific anti-double stranded DNA and anti-Sm antibody, are the mandatory tests for the diagnosis of SLE. We report a case of a 30 year old female in whom bone marrow aspiration was performed during the investigative workup for pyrexia of unknown origin. The observation of LE cells in direct bone marrow smears (without the use of anticoagulant) raised the suspicion of SLE which was later confirmed on antinuclear antibody testing. This case emphasizes the fact that a good morphological observation of marrow aspirates can provide crucial clues towards a previously unsuspected diagnosis. Moreover, in the present case, LE cells were detected in the bone marrow films spread immediately without use of anticoagulants, incubation or any other manipulation which is an exceptional finding reported very rarely in the literature. |
| format | Article |
| id | doaj-art-a02dc28b20bf41cca81fadb4798672d7 |
| institution | OA Journals |
| issn | 2035-3006 |
| language | English |
| publishDate | 2014-08-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-a02dc28b20bf41cca81fadb4798672d72025-08-20T02:08:27ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062014-08-011A Case of Systemic Lupus Erythematosus diagnosed on bone marrow aspirationMukta Pujani0Shivani Kushwaha1Neha Sethi2Anu Beniwal3Shailaja Shukla4Assistant Professor, Dept. of Pathology, Lady Hardinge Medical College, New Delhi, IndiaSenior Resident, Dept. of Pathology, Lady Hardinge Medical College, New Delhi, IndiaSenior Resident, Dept. of Pathology, Lady Hardinge Medical College, New Delhi, IndiaPost Graduate, Dept. of Pathology, Lady Hardinge Medical College, New Delhi, IndiaProfessor, Dept. of Pathology, Lady Hardinge Medical College, New Delhi, IndiaAbstract: Lupus erythematosus (LE) cell phenomenon was demonstrated in patients with systemic lupus erythematosus (SLE) in 1948. Now-a-days, antinuclear antibody testing (ANA) including the specific anti-double stranded DNA and anti-Sm antibody, are the mandatory tests for the diagnosis of SLE. We report a case of a 30 year old female in whom bone marrow aspiration was performed during the investigative workup for pyrexia of unknown origin. The observation of LE cells in direct bone marrow smears (without the use of anticoagulant) raised the suspicion of SLE which was later confirmed on antinuclear antibody testing. This case emphasizes the fact that a good morphological observation of marrow aspirates can provide crucial clues towards a previously unsuspected diagnosis. Moreover, in the present case, LE cells were detected in the bone marrow films spread immediately without use of anticoagulants, incubation or any other manipulation which is an exceptional finding reported very rarely in the literature.https://mjhid.org/index.php/mjhid/article/view/1937SLEBone marrow aspirationLE cell |
| spellingShingle | Mukta Pujani Shivani Kushwaha Neha Sethi Anu Beniwal Shailaja Shukla A Case of Systemic Lupus Erythematosus diagnosed on bone marrow aspiration Mediterranean Journal of Hematology and Infectious Diseases SLE Bone marrow aspiration LE cell |
| title | A Case of Systemic Lupus Erythematosus diagnosed on bone marrow aspiration |
| title_full | A Case of Systemic Lupus Erythematosus diagnosed on bone marrow aspiration |
| title_fullStr | A Case of Systemic Lupus Erythematosus diagnosed on bone marrow aspiration |
| title_full_unstemmed | A Case of Systemic Lupus Erythematosus diagnosed on bone marrow aspiration |
| title_short | A Case of Systemic Lupus Erythematosus diagnosed on bone marrow aspiration |
| title_sort | case of systemic lupus erythematosus diagnosed on bone marrow aspiration |
| topic | SLE Bone marrow aspiration LE cell |
| url | https://mjhid.org/index.php/mjhid/article/view/1937 |
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