The Role of GPX1 (rs1050450) Variants in Ovarian Cancer Susceptibility Within a Turkish Population
Introduction Ovarian cancer (OC) remains one of the most lethal gynecological malignancies, primarily due to challenges in early detection and the consequent poor prognosis. Genetic predisposition plays a critical role in OC development, with the Glutathione Peroxidase 1 (GPX1) gene receiving increa...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-03-01
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| Series: | Cancer Control |
| Online Access: | https://doi.org/10.1177/10732748251332441 |
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| author | Baker Alsheikh PhD Rukset Attar MD, PhD Seda Güleç Yilmaz PhD Sara Yaser Barham Selvi Duman Bakırezer PhD |
| author_facet | Baker Alsheikh PhD Rukset Attar MD, PhD Seda Güleç Yilmaz PhD Sara Yaser Barham Selvi Duman Bakırezer PhD |
| author_sort | Baker Alsheikh PhD |
| collection | DOAJ |
| description | Introduction Ovarian cancer (OC) remains one of the most lethal gynecological malignancies, primarily due to challenges in early detection and the consequent poor prognosis. Genetic predisposition plays a critical role in OC development, with the Glutathione Peroxidase 1 (GPX1) gene receiving increasing attention. The GPX1 gene polymorphism rs1050450 has been implicated in various cancers, potentially through its impact on oxidative stress mechanisms. Objective This study aimed to investigate the association between the GPX1 (rs1050450) polymorphism and the risk of developing OC in a Turkish population. Methods A retrospective case-control study was conducted involving 90 women diagnosed with OC and 90 healthy controls. Genotyping of the GPX1 (rs1050450) polymorphism was performed using real-time PCR (RT-PCR). Statistical analyses were conducted using the SPSS software, with chi-square and t-tests applied where appropriate. Results The CC genotype of the GPX1 (rs1050450) polymorphism was significantly associated with a reduced risk of OC ( P = 0.002; OR = 0.304; 95% CI = 0.161-0.577), whereas the TT genotype was linked to an increased risk, demonstrating a threefold elevation in susceptibility ( P = 0.036; OR = 3.308; 95% CI = 1.024-10.682). Additionally, the T allele was associated with an approximately threefold increased risk of developing OC ( P = 0.0002). Conclusion These findings suggest that the GPX1 (rs1050450) polymorphism may play a significant role in OC susceptibility, with the CC genotype offering potential protective effects and the TT genotype indicating increased risk. This genetic variant may serve as a useful marker for assessing OC risk; however, further studies involving larger and more diverse populations are needed to validate these results. |
| format | Article |
| id | doaj-art-a0201021c19a422ebde86062654bf58f |
| institution | OA Journals |
| issn | 1526-2359 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cancer Control |
| spelling | doaj-art-a0201021c19a422ebde86062654bf58f2025-08-20T02:19:51ZengSAGE PublishingCancer Control1526-23592025-03-013210.1177/10732748251332441The Role of GPX1 (rs1050450) Variants in Ovarian Cancer Susceptibility Within a Turkish PopulationBaker Alsheikh PhDRukset Attar MD, PhDSeda Güleç Yilmaz PhDSara Yaser BarhamSelvi Duman Bakırezer PhDIntroduction Ovarian cancer (OC) remains one of the most lethal gynecological malignancies, primarily due to challenges in early detection and the consequent poor prognosis. Genetic predisposition plays a critical role in OC development, with the Glutathione Peroxidase 1 (GPX1) gene receiving increasing attention. The GPX1 gene polymorphism rs1050450 has been implicated in various cancers, potentially through its impact on oxidative stress mechanisms. Objective This study aimed to investigate the association between the GPX1 (rs1050450) polymorphism and the risk of developing OC in a Turkish population. Methods A retrospective case-control study was conducted involving 90 women diagnosed with OC and 90 healthy controls. Genotyping of the GPX1 (rs1050450) polymorphism was performed using real-time PCR (RT-PCR). Statistical analyses were conducted using the SPSS software, with chi-square and t-tests applied where appropriate. Results The CC genotype of the GPX1 (rs1050450) polymorphism was significantly associated with a reduced risk of OC ( P = 0.002; OR = 0.304; 95% CI = 0.161-0.577), whereas the TT genotype was linked to an increased risk, demonstrating a threefold elevation in susceptibility ( P = 0.036; OR = 3.308; 95% CI = 1.024-10.682). Additionally, the T allele was associated with an approximately threefold increased risk of developing OC ( P = 0.0002). Conclusion These findings suggest that the GPX1 (rs1050450) polymorphism may play a significant role in OC susceptibility, with the CC genotype offering potential protective effects and the TT genotype indicating increased risk. This genetic variant may serve as a useful marker for assessing OC risk; however, further studies involving larger and more diverse populations are needed to validate these results.https://doi.org/10.1177/10732748251332441 |
| spellingShingle | Baker Alsheikh PhD Rukset Attar MD, PhD Seda Güleç Yilmaz PhD Sara Yaser Barham Selvi Duman Bakırezer PhD The Role of GPX1 (rs1050450) Variants in Ovarian Cancer Susceptibility Within a Turkish Population Cancer Control |
| title | The Role of GPX1 (rs1050450) Variants in Ovarian Cancer Susceptibility Within a Turkish Population |
| title_full | The Role of GPX1 (rs1050450) Variants in Ovarian Cancer Susceptibility Within a Turkish Population |
| title_fullStr | The Role of GPX1 (rs1050450) Variants in Ovarian Cancer Susceptibility Within a Turkish Population |
| title_full_unstemmed | The Role of GPX1 (rs1050450) Variants in Ovarian Cancer Susceptibility Within a Turkish Population |
| title_short | The Role of GPX1 (rs1050450) Variants in Ovarian Cancer Susceptibility Within a Turkish Population |
| title_sort | role of gpx1 rs1050450 variants in ovarian cancer susceptibility within a turkish population |
| url | https://doi.org/10.1177/10732748251332441 |
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