Time interval distribution of hepatitis B vaccine immunization among infants in China from 2017 to 2021
Infant hepatitis B vaccine coverage in China is high, with over 95% of infants immunized; however, high vaccine coverage can often mask low timeliness. The vaccination interval between the second and third doses is not clearly defined by immunization guidelines in China. This retrospective cohort st...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2024.2395087 |
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| author | Sihui Zhang Xiaoling Tian Li Wang Ming Liu Chao Wang Tianshuo Zhao Xianming Cai Xiyu Zhang Mingting Wang Juan Du Yaqiong Liu Qingbin Lu Jiang Wu Ninghua Huang Fuqiang Cui |
| author_facet | Sihui Zhang Xiaoling Tian Li Wang Ming Liu Chao Wang Tianshuo Zhao Xianming Cai Xiyu Zhang Mingting Wang Juan Du Yaqiong Liu Qingbin Lu Jiang Wu Ninghua Huang Fuqiang Cui |
| author_sort | Sihui Zhang |
| collection | DOAJ |
| description | Infant hepatitis B vaccine coverage in China is high, with over 95% of infants immunized; however, high vaccine coverage can often mask low timeliness. The vaccination interval between the second and third doses is not clearly defined by immunization guidelines in China. This retrospective cohort study assessed the time interval distribution of hepatitis B vaccination among a cohort of randomly selected live births from the Centers for Disease Control and Prevention across four provinces or municipalities in China between January 2017 and December 2021. Among the infants analyzed, 163,224 received the first dose of hepatitis B vaccine with 146,905 (90.0%) and 135,757 (83.2%) infants receiving the second and third doses, respectively. A total of 132,577 (90.2%) infants received the second dose between 28 and 61 days after the first dose. Of the 119,437 (88.0%) infants that completed the hepatitis B series between 61 and 214 days after the second dose 87,067 (64.1%) infants were vaccinated with the third dose between 151 and 180 days after the second dose. The time interval distribution varied across the four provinces or municipalities (p < .001). Of the 58,077 infants who completed the hepatitis B vaccine series, 36,377 (62.6%) infants used the same type of hepatitis B vaccine for all three doses. Overall, the timeliness of hepatitis B vaccination for infants was lower than expected, with regional disparities observed. This highlights the need for improved timeliness through the introduction of a defined timeframe for the last two doses of vaccine and training for obstetricians and related personnel. |
| format | Article |
| id | doaj-art-a01cf82960c24a8e96f8b8ec52a66035 |
| institution | DOAJ |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-a01cf82960c24a8e96f8b8ec52a660352025-08-20T03:21:46ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2024-12-0120110.1080/21645515.2024.2395087Time interval distribution of hepatitis B vaccine immunization among infants in China from 2017 to 2021Sihui Zhang0Xiaoling Tian1Li Wang2Ming Liu3Chao Wang4Tianshuo Zhao5Xianming Cai6Xiyu Zhang7Mingting Wang8Juan Du9Yaqiong Liu10Qingbin Lu11Jiang Wu12Ninghua Huang13Fuqiang Cui14Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, P. R. ChinaInstitute for Immunization and Prevention, Inner Mongolia Center for Disease Control and Prevention, Hohhot City, People’s Republic of ChinaInstitute for Immunization and Prevention, Suzhou Center for Disease Control and Prevention, Suzhou, ChinaDepartment of Infectious Disease, Guizhou Provincial Center for Disease Control and Prevention, Guiyang, ChinaDepartment of Laboratorial Science and Technology & Vaccine Research Center, School of Public Health, Peking University, Beijing, P. R. ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, P. R. ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, P. R. ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, P. R. ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, P. R. ChinaDepartment of Laboratorial Science and Technology & Vaccine Research Center, School of Public Health, Peking University, Beijing, P. R. ChinaDepartment of Laboratorial Science and Technology & Vaccine Research Center, School of Public Health, Peking University, Beijing, P. R. ChinaDepartment of Laboratorial Science and Technology & Vaccine Research Center, School of Public Health, Peking University, Beijing, P. R. ChinaInstitute for Immunization and Prevention, Beijing Center for Disease Prevention and Control, Beijing Research Center for Preventive Medicine, Beijing, ChinaDepartment of Laboratorial Science and Technology & Vaccine Research Center, School of Public Health, Peking University, Beijing, P. R. ChinaDepartment of Laboratorial Science and Technology & Vaccine Research Center, School of Public Health, Peking University, Beijing, P. R. ChinaInfant hepatitis B vaccine coverage in China is high, with over 95% of infants immunized; however, high vaccine coverage can often mask low timeliness. The vaccination interval between the second and third doses is not clearly defined by immunization guidelines in China. This retrospective cohort study assessed the time interval distribution of hepatitis B vaccination among a cohort of randomly selected live births from the Centers for Disease Control and Prevention across four provinces or municipalities in China between January 2017 and December 2021. Among the infants analyzed, 163,224 received the first dose of hepatitis B vaccine with 146,905 (90.0%) and 135,757 (83.2%) infants receiving the second and third doses, respectively. A total of 132,577 (90.2%) infants received the second dose between 28 and 61 days after the first dose. Of the 119,437 (88.0%) infants that completed the hepatitis B series between 61 and 214 days after the second dose 87,067 (64.1%) infants were vaccinated with the third dose between 151 and 180 days after the second dose. The time interval distribution varied across the four provinces or municipalities (p < .001). Of the 58,077 infants who completed the hepatitis B vaccine series, 36,377 (62.6%) infants used the same type of hepatitis B vaccine for all three doses. Overall, the timeliness of hepatitis B vaccination for infants was lower than expected, with regional disparities observed. This highlights the need for improved timeliness through the introduction of a defined timeframe for the last two doses of vaccine and training for obstetricians and related personnel.https://www.tandfonline.com/doi/10.1080/21645515.2024.2395087Time intervalhepatitis B vaccinationinfantstype of vaccinelast two dose |
| spellingShingle | Sihui Zhang Xiaoling Tian Li Wang Ming Liu Chao Wang Tianshuo Zhao Xianming Cai Xiyu Zhang Mingting Wang Juan Du Yaqiong Liu Qingbin Lu Jiang Wu Ninghua Huang Fuqiang Cui Time interval distribution of hepatitis B vaccine immunization among infants in China from 2017 to 2021 Human Vaccines & Immunotherapeutics Time interval hepatitis B vaccination infants type of vaccine last two dose |
| title | Time interval distribution of hepatitis B vaccine immunization among infants in China from 2017 to 2021 |
| title_full | Time interval distribution of hepatitis B vaccine immunization among infants in China from 2017 to 2021 |
| title_fullStr | Time interval distribution of hepatitis B vaccine immunization among infants in China from 2017 to 2021 |
| title_full_unstemmed | Time interval distribution of hepatitis B vaccine immunization among infants in China from 2017 to 2021 |
| title_short | Time interval distribution of hepatitis B vaccine immunization among infants in China from 2017 to 2021 |
| title_sort | time interval distribution of hepatitis b vaccine immunization among infants in china from 2017 to 2021 |
| topic | Time interval hepatitis B vaccination infants type of vaccine last two dose |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2024.2395087 |
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